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SCP2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS645070

This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
SCP2, Polyclonal Antibody
Full Product Name
SCP2, NT (SCP2, Non-specific lipid-transfer protein, Propanoyl-CoA C-acyltransferase, SCP-chi, SCPX, Sterol carrier protein 2, Sterol carrier protein X)
Product Gene Name
anti-SCP2 antibody
Product Synonym Names
Anti -SCP2, NT (SCP2, Non-specific lipid-transfer protein, Propanoyl-CoA C-acyltransferase, SCP-chi, SCPX, Sterol carrier protein 2, Sterol carrier protein X)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
58,994 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (53392901..53517289). Location: 1p32
OMIM
184755
3D Structure
ModBase 3D Structure for P22307
Immunogen
SCP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-43 amino acids from the N-terminal region of human SCP2.

Product Categories/Family for anti-SCP2 antibody

Antibodies; Abs to Enzymes; Acyltransferase
Applications Tested/Suitable for anti-SCP2 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-SCP2 antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Western Blot (WB) of anti-SCP2 antibody

SCP2 Antibody (N-term) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the SCP2 antibody detected the SCP2 protein (arrow).
Rabbit Anti-SCP2 Polyclonal Antibody – Cat# MBS645070

Immunohistochemistry (IHC) of anti-SCP2 antibody

SCP2 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SCP2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-SCP2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS645070

Other Notes

Small volumes of anti-SCP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SCP2 purchase

MBS645070 is an antibody targeting SCP2. Also known as SCP2, NT (SCP2, Non-specific lipid-transfer protein, Propanoyl-CoA C-acyltransferase, SCP-chi, SCPX, Sterol carrier protein 2, Sterol carrier protein X). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SCP2. It may not necessarily be applicable to this product.

NCBI GI #
263551
NCBI GeneID
6342
NCBI Accession #
AAB24921.1
UniProt Primary Accession #
P22307
UniProt Secondary Accession #
Q15432; Q16622; Q5VVZ1; Q6NXF4; A6NM69; B4DGJ9; B4DHP6; C9JC79; D3DQ37; E1B6W5; F2Z3J1
UniProt Related Accession #
P22307
NCBI Official Full Name
sterol carrier protein 2
NCBI Official Synonym Full Names
sterol carrier protein 2
NCBI Official Symbol
SCP2
NCBI Official Synonym Symbols
NLTP; SCPX; SCP-2; SCP-X; NSL-TP; SCP-CHI
UniProt Protein Name
Non-specific lipid-transfer protein
UniProt Synonym Protein Names
Propanoyl-CoA C-acyltransferase; SCP-chi; SCPX; Sterol carrier protein 2; SCP-2; Sterol carrier protein X
Protein Family
SCP2 sterol-binding domain-containing protein
UniProt Gene Name
SCP2
UniProt Synonym Gene Names
NSL-TP; SCP-2; SCP-X
UniProt Entry Name
NLTP_HUMAN
NCBI Protein Information
non-specific lipid-transfer protein; sterol carrier protein X; propanoyl-CoA C-acyltransferase

UniProt Comments for SCP2

SCP2: Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis. Defects in SCP2 are a cause of leukoencephalopathy with dystonia and motor neuropathy (LDMN); also known as sterol carrier protein 2 deficiency. LDMN is a syndrome characterized by leukoencephalopathy, dystonic head tremor, spasmodic torticollis and reduced tendon reflexes in lower extremities. Additional features include hyposmia, pathologic saccadic eye movements, a slight hypoacusis, accumulation of branched-chain pristanic acid in plasma, and the presence of abnormal bile alcohol glucuronides in urine. 3 isoforms of the human protein are produced by alternative promoter.

Protein type: Transferase; Lipid Metabolism - primary bile acid biosynthesis; EC 2.3.1.176; Lipid-binding; Mitochondrial

Chromosomal Location of Human Ortholog: 1p32

Cellular Component: nucleoplasm; peroxisomal matrix; protein complex; mitochondrion; membrane; intracellular membrane-bound organelle; cytoplasm; peroxisome

Molecular Function: protein binding; acyl-CoA binding; cholesterol binding; phosphatidylinositol transporter activity; propanoyl-CoA C-acyltransferase activity; receptor binding

Biological Process: bile acid biosynthetic process; progesterone biosynthetic process; fatty acid beta-oxidation using acyl-CoA oxidase; peroxisome organization and biogenesis; inositol trisphosphate biosynthetic process; bile acid metabolic process; unsaturated fatty acid metabolic process; positive regulation of intracellular cholesterol transport; phospholipid transport; cellular lipid metabolic process; lipid transport; steroid biosynthetic process; positive regulation of steroid metabolic process

Disease: Leukoencephalopathy With Dystonia And Motor Neuropathy
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Research Articles on SCP2

1. The Peroxisomal targeting signal 1 in Scp2 is autonomous and is essential for binding to pex5.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SCP2 antibody

 Reference Product  PubMed Publications
 HSD17B4 antibody  >1 publications with SCP2 and HSD17B4

Pathways associated with anti-SCP2 antibody

 Products by Pathway  Pathway Diagram
 Beta-oxidation Of Pristanoyl-CoA Pathway antibodies  Beta-oxidation Of Pristanoyl-CoA Pathway Diagram
 Bile Acid And Bile Salt Metabolism Pathway antibodies  Bile Acid And Bile Salt Metabolism Pathway Diagram
 Bile Acid Biosynthesis, Cholesterol => Cholate Pathway antibodies  Bile Acid Biosynthesis, Cholesterol => Cholate Pathway Diagram
 Bile Acid Biosynthesis, Cholesterol => Cholate Pathway antibodies  Bile Acid Biosynthesis, Cholesterol => Cholate Pathway Diagram
 DNA Damage Response (only ATM Dependent) Pathway antibodies  DNA Damage Response (only ATM Dependent) Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Mitochondrial LC-Fatty Acid Beta-Oxidation Pathway antibodies  Mitochondrial LC-Fatty Acid Beta-Oxidation Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram

Diseases associated with anti-SCP2 antibody

 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >13 publications with SCP2 and Fatty Liver
 Liver Diseases Antibodies  >5 publications with SCP2 and Liver Diseases
 Brain Diseases Antibodies  >5 publications with SCP2 and Brain Diseases
 Hypertrophy Antibodies  >4 publications with SCP2 and Hypertrophy
 Inflammation Antibodies  >3 publications with SCP2 and Inflammation
 Disease Models, Animal Antibodies  >3 publications with SCP2 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >2 publications with SCP2 and Cardiovascular Diseases
 Hyperplasia Antibodies  >2 publications with SCP2 and Hyperplasia
 Fibrosis Antibodies  >1 publications with SCP2 and Fibrosis
 Hepatomegaly Antibodies  >1 publications with SCP2 and Hepatomegaly

Organs/Tissues associated with anti-SCP2 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >49 publications with SCP2 and Liver
 Testis Antibodies  >20 publications with SCP2 and Testis
 Mammary Gland Antibodies  >16 publications with SCP2 and Mammary Gland
 Ovary Antibodies  >14 publications with SCP2 and Ovary
 Blood Antibodies  >13 publications with SCP2 and Blood
 Adrenal Gland Antibodies  >13 publications with SCP2 and Adrenal Gland
 Nerve Antibodies  >6 publications with SCP2 and Nerve
 Intestine Antibodies  >4 publications with SCP2 and Intestine
 Bone Antibodies  >4 publications with SCP2 and Bone
 Embryonic Tissue Antibodies  >4 publications with SCP2 and Embryonic Tissue
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