Rabbit Anti-SCRIB Polyclonal Antibody – Cat# MBS6345416

SCRIB Antibody (N-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the SCRIB antibody detected the SCRIB protein (arrow).

SCRIB Antibody – Rabbit Polyclonal

Name: SCRIB Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6345416
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6345416

SCRIB is a cytoplasmic multimodular scaffold protein targeted to epithelial adherens junctions and neuronal presynaptic compartments. SCRIB and its orthologs in vertebrates and invertebrates participate in cell polarization (summary by Nola et al., 2008… More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SCRIB, Polyclonal Antibody

Full Product Name

SCRIB, NT (SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL, Protein scribble homolog, Protein LAP4) (APC)

Product Gene Name

anti-SCRIB antibody

Product Synonym Names

SCRIB; CRIB1; KIAA0147; LAP4; SCRB1; VARTUL; Protein scribble homolog; Protein LAP4

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

OMIM

182940

3D Structure

ModBase 3D Structure for Q14160

Immunogen

SCRIB antibody is generated from rabbits immunized with a KLH conjugated synthetic between 381-410 amino acids selected from the N-terminal region of human SCRIB.

Conjugate

APC

Note

Preservative Free

Special Handling

Light sensitive

Product Categories/Family for anti-SCRIB antibody

Antibodies; KIAA; orf

Applications Tested/Suitable for anti-SCRIB antibody

Western Blot (WB), FLISA

Application Notes for anti-SCRIB antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-SCRIB antibody

Liu, H., et al. J. Virol. 84(21):11164-11174(2010). Nagasaka, K., et al. Oncogene 29(38):5311-5321(2010). Ivanov, A.I., et al. Am. J. Pathol. 176(1):134-145(2010). Ouyang, Z., et al. Oncol. Res. 18 (11-12), 593-599 (2010): Arnaud, C., et al. FEBS Lett. 583(14):2326-2332(2009).

Other Notes

Small volumes of anti-SCRIB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SCRIB purchase

MBS6345416 is an antibody targeting SCRIB. Also known as SCRIB, NT (SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL, Protein scribble homolog, Protein LAP4) (APC). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SCRIB. It may not necessarily be applicable to this product.

NCBI GI #

45827731

NCBI GeneID

23513

NCBI Accession #

NP_874365.2

UniProt Primary Accession #

Q14160

UniProt Related Accession #

Q14160

GenBank Nucleotide #

NP_874365.2

NCBI Official Full Name

protein scribble homolog isoform a

NCBI Official Synonym Full Names

scribble planar cell polarity protein

NCBI Official Symbol

SCRIB

NCBI Official Synonym Symbols

CRIB1; SCRB1; SCRIB1; Vartul

UniProt Protein Name

Protein scribble homolog

UniProt Synonym Protein Names

Protein LAP4

Protein Family

Protein

UniProt Gene Name

SCRIB

UniProt Synonym Gene Names

CRIB1; KIAA0147; LAP4; SCRB1; VARTUL; Scribble; hScrib

UniProt Entry Name

SCRIB_HUMAN

NCBI Protein Information

protein scribble homolog

NCBI Summary for SCRIB

This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Research Articles on SCRIB

1. our study revealed that loss of Scribble confers cisplatin resistance during NSCLC chemotherapy, an effect that is mediated via Nox2/ROS and Nrf2/PD-L1 signaling.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.