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SDR16C5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6345657

RDHE2 belongs to a family of short-chain alcohol dehydrogenases/reductases that catalyze the first and rate-limiting step that generates retinaldehyde from retinol (Matsuzaka et al., 2002 [PubMed 12372410]). More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SDR16C5, Polyclonal Antibody
Full Product Name
SDR16C5, ID (SDR16C5, RDHE2, Epidermal retinol dehydrogenase 2, Retinal short-chain dehydrogenase reductase 2, Short-chain dehydrogenase/reductase family 16C member 5) (AP)
Product Gene Name
anti-SDR16C5 antibody
Product Synonym Names
SDR16C5; RDHE2; Epidermal retinol dehydrogenase 2; Retinal short-chain dehydrogenase reductase 2; Short-chain dehydrogenase/reductase family 16C member 5
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
29,164 Da
OMIM
608989
3D Structure
ModBase 3D Structure for Q8N3Y7
Immunogen
SDR16C5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-151 amino acids from the Central region of human SDR16C5.
Conjugate
AP
Note
Preservative Free

Product Categories/Family for anti-SDR16C5 antibody

Antibodies; Enzymes; Dehydrogenase
Applications Tested/Suitable for anti-SDR16C5 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-SDR16C5 antibody
WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-SDR16C5 antibody

SDR16C5 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the SDR16C5 antibody detected the SDR16C5 protein (arrow).
Rabbit Anti-SDR16C5 Polyclonal Antibody – Cat# MBS6345657

Product References and Citations for anti-SDR16C5 antibody

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Zhao, J., et al. BMC Med. Genet. 11, 96 (2010): Takahashi, Y., et al. Biochem. J. 419(1):113-122(2009). Soranzo, N., et al. PLoS Genet. 5 (4), E1000445 (2009): Lee, S.A., et al. Chem. Biol. Interact. 178 (1-3), 182-187 (2009).

Other Notes

Small volumes of anti-SDR16C5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SDR16C5 purchase

MBS6345657 is an antibody targeting SDR16C5. Also known as SDR16C5, ID (SDR16C5, RDHE2, Epidermal retinol dehydrogenase 2, Retinal short-chain dehydrogenase reductase 2, Short-chain dehydrogenase/reductase family 16C member 5) (AP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SDR16C5. It may not necessarily be applicable to this product.

NCBI GI #
40807363
NCBI GeneID
195814
NCBI Accession #
NP_620419.2
UniProt Primary Accession #
Q8N3Y7
UniProt Secondary Accession #
Q330K3; Q8TDV9; Q96LX1; B4DGK2
UniProt Related Accession #
Q8N3Y7
GenBank Nucleotide #
NM_138969.2
NCBI Official Full Name
epidermal retinol dehydrogenase 2
NCBI Official Synonym Full Names
short chain dehydrogenase/reductase family 16C, member 5
NCBI Official Symbol
SDR16C5
NCBI Official Synonym Symbols
RDH#2; RDHE2; RDH-E2
UniProt Protein Name
Epidermal retinol dehydrogenase 2
UniProt Synonym Protein Names
Retinal short-chain dehydrogenase reductase 2; retSDR2; Short-chain dehydrogenase/reductase family 16C member 5
Protein Family
Epidermal retinol dehydrogenase
UniProt Gene Name
SDR16C5
UniProt Synonym Gene Names
RDHE2; EPHD-2; RDH-E2; retSDR2
UniProt Entry Name
RDHE2_HUMAN
NCBI Protein Information
epidermal retinol dehydrogenase 2; EPHD-2; epidermal retinal dehydrogenase 2; retSDR2; retinal short chain dehydrogenase reductase; retinal short-chain dehydrogenase reductase 2; short-chain dehydrogenase/reductase family 16C member 5

UniProt Comments for SDR16C5

RDHE2: Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans- retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Oxidoreductase; Membrane protein, integral; EC 1.1.1.105

Chromosomal Location of Human Ortholog: 8q12.1

Cellular Component: endoplasmic reticulum membrane; integral to membrane

Molecular Function: retinol dehydrogenase activity

Biological Process: retinal metabolic process; retinol metabolic process; detection of light stimulus involved in visual perception; keratinocyte proliferation
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Research Articles on SDR16C5

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SDR16C5 antibody

 Reference Product  PubMed Publications
 PLAG1 antibody  >3 publications with SDR16C5 and PLAG1
 CHCHD7 antibody  >3 publications with SDR16C5 and CHCHD7

Pathways associated with anti-SDR16C5 antibody

 Products by Pathway  Pathway Diagram
 RA Biosynthesis Pathway antibodies  RA Biosynthesis Pathway Diagram
 Retinol Metabolism Pathway antibodies  Retinol Metabolism Pathway Diagram
 Retinol Metabolism Pathway antibodies  Retinol Metabolism Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Retinoic Acid Pathway antibodies  Signaling By Retinoic Acid Pathway Diagram
 Retinoate Biosynthesis I Pathway antibodies  Retinoate Biosynthesis I Pathway Diagram
 Retinoate Biosynthesis I Pathway antibodies  Retinoate Biosynthesis I Pathway Diagram

Diseases associated with anti-SDR16C5 antibody

 Disease Name  Pubmed Publications
 Neural Tube Defects Antibodies  >1 publications with SDR16C5 and Neural Tube Defects
 Fibrosis Antibodies  >1 publications with SDR16C5 and Fibrosis
 Inflammation Antibodies  >1 publications with SDR16C5 and Inflammation

Organs/Tissues associated with anti-SDR16C5 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >1 publications with SDR16C5 and Lung
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