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SE6L2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6345709

MBS6345709 is an antibody targeting SE6L2. Also known as SE6L2, CT (SEZ6L2, PSK, Seizure 6-like protein 2) (MaxLight 650). Reactive in Human. Host: Rabbit. SE6L2 may contribute to specialized endoplasmic reticulum functions in neurons. More details

$1060 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SE6L2, Polyclonal Antibody
Full Product Name
SE6L2, CT (SEZ6L2, PSK, Seizure 6-like protein 2) (MaxLight 650)
Product Gene Name
anti-SE6L2 antibody
Product Synonym Gene Name
SEZ6L2
Product Synonym Names
SEZ6L2; PSK; Seizure 6-like protein 2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.
Purity/Purification
Purified by Protein A and Peptide Affinity Chromatography.
Specificity
Recognizes human SE6L2.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
86,861 Da
3D Structure
ModBase 3D Structure for Q6UXD5
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 879-907 in the C-terminal region of human SE6L2, UniProt Accession #Q6UXD5; Q4V9Z5; Q29RN8. Species sequence homology: bovine, mouse
Conjugate
MaxLight650
Note
Preservative Free

Product Categories/Family for anti-SE6L2 antibody

Antibodies; Proteins
Applications Tested/Suitable for anti-SE6L2 antibody
Western Blot (WB), Flow Cytometry (FC/FACS), FLISA
Application Notes for anti-SE6L2 antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-SE6L2 antibody

Western Blot analysis in K562 cell line lysates (35ug/lane) usingMBS648200. SE6L2 (arrow) was detected using the purified Pab.
Rabbit Anti-SE6L2 Polyclonal Antibody – Cat# MBS6345709

Flow Cytometry (FC/FACS) of anti-SE6L2 antibody

Flow Cytometric analysis of K562 cells using MBS648200 (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-SE6L2 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6345709

Product References and Citations for anti-SE6L2 antibody

1. Polasek, O., et al. Croat. Med. J. 50(1):7-16(2009). 2. Kumar, R.A., et al. PLoS ONE 4 (2), E4582 (2009). 3. Lamesch, P., et al. Genomics 89(3):307-315(2007).

Other Notes

Small volumes of anti-SE6L2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SE6L2. It may not necessarily be applicable to this product.

NCBI GI #
6912612
NCBI GeneID
26470
NCBI Accession #
NP_036542.1
UniProt Primary Accession #
Q6UXD5
UniProt Secondary Accession #
Q29RN8
UniProt Related Accession #
Q6UXD5
GenBank Nucleotide #
NM_012410.3
NCBI Official Full Name
seizure 6-like protein 2 isoform 1
NCBI Official Synonym Full Names
seizure related 6 homolog (mouse)-like 2
NCBI Official Symbol
SEZ6L2
NCBI Official Synonym Symbols
PSK-1
UniProt Protein Name
Seizure 6-like protein 2
UniProt Gene Name
SEZ6L2
UniProt Synonym Gene Names
PSK
UniProt Entry Name
SE6L2_HUMAN
NCBI Protein Information
seizure 6-like protein 2; seizure related 6-like protein 2; type I transmembrane receptor (seizure-related protein)

NCBI Summary for SE6L2

This gene encodes a seizure-related protein that is localized on the cell surface. The gene is located in a region of chromosome 16p11.2 that is thought to contain candidate genes for autism spectrum disorders (ASD), though there is no evidence directly implicating this gene in ASD. Increased expression of this gene has been found in lung cancers, and the protein is therefore considered to be a novel prognostic marker for lung cancer. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
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UniProt Comments for SE6L2

SEZ6L2: May contribute to specialized endoplasmic reticulum functions in neurons. Belongs to the SEZ6 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: endoplasmic reticulum membrane; plasma membrane; integral to membrane
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Research Articles on SE6L2

1. These results provide an extensive ascertainment of the genetic variability of SEZ6L2 in human populations and do not support a major role for SEZ6L2 sequence variations in the susceptibility to autism spectrum disorders.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SE6L2 antibody

 Reference Product  PubMed Publications
 DOC2A antibody  >1 publications with SE6L2 and DOC2A

Diseases associated with anti-SE6L2 antibody

 Disease Name  Pubmed Publications
 Central Nervous System Diseases Antibodies  >2 publications with SE6L2 and Central Nervous System Diseases
 Lung Neoplasms Antibodies  >1 publications with SE6L2 and Lung Neoplasms
 Autistic Disorder Antibodies  >1 publications with SE6L2 and Autistic Disorder

Organs/Tissues associated with anti-SE6L2 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >2 publications with SE6L2 and Nerve
 Pancreas Antibodies  >2 publications with SE6L2 and Pancreas
 Bone Antibodies  >1 publications with SE6L2 and Bone
 Lung Antibodies  >1 publications with SE6L2 and Lung
 Brain Antibodies  >1 publications with SE6L2 and Brain
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