Rabbit Anti-SENP1 Polyclonal Antibody – Cat# MBS3903257

Detection of human SENP1 by western blot and immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded) and HEK293T (T; 50 ug) cells. Antibodies: Affinity purified rabbit anti-SENP1 antibody MBS3903257 used for WB at 0.04 ug/ml (A) and 0.4 ug/ml (B) and used for IP at 3 ug/mg lysate. SENP1 was also immunoprecipitated by rabbit anti-SENP1 antibody MBS3903258, which recognizes a downstream epitope. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 30 seconds (B).

SENP1 Antibody – Rabbit Polyclonal

Name: SENP1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS3903257
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3903257

SENP1 (sentrin-specific protease) functions as a protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins.… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SENP1, Polyclonal Antibody

Full Product Name

Rabbit anti-SENP1 Antibody, Affinity Purified

Product Gene Name

anti-SENP1 antibody

Product Synonym Names

sentrin/SUMO-specific protease SENP1; sentrin-specific protease 1; SUMO1/sentrin specific peptidase 1; SUMO1/sentrin specific protease 1; SuPr-2; Sentrin-specific protease 1; SUMO specific peptidase 1

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human

Form/Format

Liquid. Whole IgG. Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide

Purity/Purification

Antigen Affinity Purified

Concentration

200ug/ml (lot specific)

Preparation and Storage

Store at 2-8 degree C
Shelf Life: 1 year from date of receipt

Molecular Weight

73,351 Da

OMIM

612157

3D Structure

ModBase 3D Structure for Q9P0U3

Predicted Reactivity

Orangutan

Immunogen

Between 1 and 50

Conjugation

Unconjugated

Product Categories/Family for anti-SENP1 antibody

Primary Antibodies

Applications Tested/Suitable for anti-SENP1 antibody

Western Blot (WB), Immunoprecipitation (IP)

Application Notes for anti-SENP1 antibody

WB: 1:2000-1:10,000
IP: 6ug/mg lysate

Other Notes

Small volumes of anti-SENP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SENP1 purchase

MBS3903257 is an antibody targeting SENP1. Also known as Rabbit anti-SENP1 Antibody, Affinity Purified. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SENP1. It may not necessarily be applicable to this product.

NCBI GI #

7657550

NCBI GeneID

29843

NCBI Accession #

NP_055369.1

UniProt Primary Accession #

Q9P0U3

UniProt Secondary Accession #

Q86XC8; A8K7P5

UniProt Related Accession #

Q9P0U3

GenBank Nucleotide #

NM_014554.2

NCBI Official Synonym Full Names

SUMO1/sentrin specific peptidase 1

NCBI Official Symbol

SENP1

NCBI Official Synonym Symbols

SuPr-2

UniProt Protein Name

Sentrin-specific protease 1

UniProt Synonym Protein Names

Sentrin/SUMO-specific protease SENP1

Protein Family

Sentrin-specific protease

UniProt Gene Name

SENP1

UniProt Entry Name

SENP1_HUMAN

NCBI Protein Information

sentrin-specific protease 1

NCBI Summary for SENP1

This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

UniProt Comments for SENP1

SENP1: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity. Belongs to the peptidase C48 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Protease; EC 3.4.22.68

Chromosomal Location of Human Ortholog: 12q13.1

Cellular Component: nucleoplasm; nuclear membrane; focal adhesion; cytoplasm; nucleus

Molecular Function: protein binding; endopeptidase activity; SUMO-specific protease activity

Biological Process: caspase activation; protein desumoylation; cellular protein metabolic process; protein sumoylation; positive regulation of transcription from RNA polymerase II promoter; proteolysis; post-translational protein modification; negative regulation of proteasomal ubiquitin-dependent protein catabolic process

Research Articles on SENP1

1. Over-expression of small ubiquitin-like modifier proteases 1 predicts chemo-sensitivity and poor survival in non-small cell lung cancer.(

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SENP1 antibody

Reference Product	PubMed Publications
SUMO1 antibody	>95 publications with SENP1 and SUMO1
SUMO2 antibody	>20 publications with SENP1 and SUMO2
RANGAP1 antibody	>5 publications with SENP1 and RANGAP1
CCND1 antibody	>4 publications with SENP1 and CCND1
CDKN1A antibody	>2 publications with SENP1 and CDKN1A
GMNN antibody	>1 publications with SENP1 and GMNN
HDAC1 antibody	>1 publications with SENP1 and HDAC1

Pathways associated with anti-SENP1 antibody

Products by Pathway	Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Post-translational Protein Modification Pathway antibodies	Post-translational Protein Modification Pathway Diagram
Processing And Activation Of SUMO Pathway antibodies	Processing And Activation Of SUMO Pathway Diagram
Regulation Of Androgen Receptor Activity Pathway antibodies	Regulation Of Androgen Receptor Activity Pathway Diagram
SUMO Is Proteolytically Processed Pathway antibodies	SUMO Is Proteolytically Processed Pathway Diagram
SUMOylation Pathway antibodies	SUMOylation Pathway Diagram

Diseases associated with anti-SENP1 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>12 publications with SENP1 and Inflammation
Cardiovascular Diseases Antibodies	>5 publications with SENP1 and Cardiovascular Diseases
Nervous System Diseases Antibodies	>2 publications with SENP1 and Nervous System Diseases
Anemia Antibodies	>2 publications with SENP1 and Anemia
Hypertension Antibodies	>2 publications with SENP1 and Hypertension
Gastrointestinal Diseases Antibodies	>2 publications with SENP1 and Gastrointestinal Diseases
Embryo Loss Antibodies	>2 publications with SENP1 and Embryo Loss
Kidney Diseases Antibodies	>1 publications with SENP1 and Kidney Diseases
Carcinoma, Hepatocellular Antibodies	>1 publications with SENP1 and Carcinoma, Hepatocellular
Liver Neoplasms Antibodies	>1 publications with SENP1 and Liver Neoplasms

Organs/Tissues associated with anti-SENP1 antibody

Organ/Tissue Name	Pubmed Publications
Prostate Antibodies	>14 publications with SENP1 and Prostate
Blood Antibodies	>9 publications with SENP1 and Blood
Brain Antibodies	>9 publications with SENP1 and Brain
Lung Antibodies	>7 publications with SENP1 and Lung
Vascular Antibodies	>6 publications with SENP1 and Vascular
Kidney Antibodies	>6 publications with SENP1 and Kidney
Liver Antibodies	>4 publications with SENP1 and Liver
Pancreas Antibodies	>3 publications with SENP1 and Pancreas
Lymph Node Antibodies	>3 publications with SENP1 and Lymph Node
Bone Antibodies	>3 publications with SENP1 and Bone