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SENP2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6498801

MBS6498801 is an antibody targeting SENP2. Also known as SENP2, CT (Sentrin-specific Protease 2, Sentrin/SUMO-specific Protease SENP2, SMT3-Specific Isopeptidase 2, Smt3ip2, Axam2, KIAA1331) (PE). Reactive in Human. Host: Rabbit. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SENP2, Polyclonal Antibody
Full Product Name
SENP2, CT (Sentrin-specific Protease 2, Sentrin/SUMO-specific Protease SENP2, SMT3-Specific Isopeptidase 2, Smt3ip2, Axam2, KIAA1331) (PE)
Product Gene Name
anti-SENP2 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Protein G Affinity Chromatography.
Specificity
Recognizes human SENP2.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
66,358 Da
OMIM
608261
3D Structure
ModBase 3D Structure for Q9HC62
Immunogen
Synthetic peptide selected from the C-terminal region of human SENP2 (KLH).
Conjugate
PE
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-SENP2 antibody

Antibodies; Ubiquitin
Applications Tested/Suitable for anti-SENP2 antibody
Immunohistochemistry (IHC), FLISA, Western Blot (WB)
Application Notes for anti-SENP2 antibody
IHC: 1:50-1:100
FLISA: 1:1,000
WB: 1:100-1:500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-SENP2 antibody

Western blot analysis of SENP2 polyclonal antibody in HL-60 cell lysate. SENP2 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
Rabbit Anti-SENP2 Polyclonal Antibody – Cat# MBS6498801

Immunohistochemistry (IHC) of anti-SENP2 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-SENP2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6498801

Product References and Citations for anti-SENP2 antibody

1. Zhang, H., et al., Mol. Cell. Biol. 22(18):6498-6508 (2002). 2. Hang, J., et al., J. Biol. Chem. 277(22):19961-19966 (2002). 3. Nishida, T., et al., J. Biol. Chem. 276(42):39060-39066 (2001).

Other Notes

Small volumes of anti-SENP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SENP2. It may not necessarily be applicable to this product.

NCBI GI #
54607091
NCBI GeneID
59343
NCBI Accession #
NP_067640
UniProt Primary Accession #
Q9HC62
UniProt Secondary Accession #
Q8IW97; Q96SR2; Q9P2L5; B4DQ42
UniProt Related Accession #
Q9HC62
GenBank Nucleotide #
NM_021627
NCBI Official Full Name
sentrin-specific protease 2
NCBI Official Synonym Full Names
SUMO1/sentrin/SMT3 specific peptidase 2
NCBI Official Symbol
SENP2
NCBI Official Synonym Symbols
AXAM2; SMT3IP2
UniProt Protein Name
Sentrin-specific protease 2
UniProt Synonym Protein Names
Axam2; SMT3-specific isopeptidase 2; Smt3ip2; Sentrin/SUMO-specific protease SENP2
Protein Family
Sentrin-specific protease
UniProt Gene Name
SENP2
UniProt Synonym Gene Names
KIAA1331; Smt3ip2
UniProt Entry Name
SENP2_HUMAN
NCBI Protein Information
sentrin-specific protease 2; SMT3-specific isopeptidase 2; SUMO1/sentrin/SMT3 specific protease 2; sentrin/SUMO-specific protease SENP2

UniProt Comments for SENP2

SENP2: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Belongs to the peptidase C48 family.

Protein type: Protease; EC 3.4.22.68

Chromosomal Location of Human Ortholog: 3q27.2

Cellular Component: nucleoplasm; PML body; nuclear membrane; nuclear pore; cytoplasmic vesicle

Molecular Function: protein domain specific binding; protein binding; SUMO-specific protease activity

Biological Process: protein desumoylation; mRNA transport; Wnt receptor signaling pathway; heart development; regulation of Wnt receptor signaling pathway; dorsal/ventral axis specification; proteolysis; post-translational protein modification; negative regulation of DNA damage response, signal transduction by p53 class mediator; regulation of DNA endoreduplication; protein transport; protein sumoylation; cellular protein metabolic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; negative regulation of protein binding
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SENP2 antibody

 Reference Product  PubMed Publications
 SUMO1 antibody  >7 publications with SENP2 and SUMO1
 SUMO3 antibody  >5 publications with SENP2 and SUMO3
 PML antibody  >4 publications with SENP2 and PML
 NUP153 antibody  >4 publications with SENP2 and NUP153

Pathways associated with anti-SENP2 antibody

 Products by Pathway  Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Nuclear Pore Complex Pathway antibodies  Nuclear Pore Complex Pathway Diagram
 Nuclear Pore Complex Pathway antibodies  Nuclear Pore Complex Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Processing And Activation Of SUMO Pathway antibodies  Processing And Activation Of SUMO Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 SUMO Is Proteolytically Processed Pathway antibodies  SUMO Is Proteolytically Processed Pathway Diagram
 SUMOylation Pathway antibodies  SUMOylation Pathway Diagram
 Wnt Signaling Pathway NetPath antibodies  Wnt Signaling Pathway NetPath Diagram

Diseases associated with anti-SENP2 antibody

 Disease Name  Pubmed Publications
 Death Antibodies  >6 publications with SENP2 and Death
 Cardiovascular Diseases Antibodies  >2 publications with SENP2 and Cardiovascular Diseases
 Inflammation Antibodies  >2 publications with SENP2 and Inflammation
 Congenital Abnormalities Antibodies  >1 publications with SENP2 and Congenital Abnormalities
 Weight Loss Antibodies  >1 publications with SENP2 and Weight Loss
 Carcinoma, Hepatocellular Antibodies  >1 publications with SENP2 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with SENP2 and Liver Neoplasms
 Liver Diseases Antibodies  >1 publications with SENP2 and Liver Diseases

Organs/Tissues associated with anti-SENP2 antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >4 publications with SENP2 and Heart
 Prostate Antibodies  >3 publications with SENP2 and Prostate
 Bone Antibodies  >3 publications with SENP2 and Bone
 Vascular Antibodies  >3 publications with SENP2 and Vascular
 Brain Antibodies  >3 publications with SENP2 and Brain
 Muscle Antibodies  >2 publications with SENP2 and Muscle
 Placenta Antibodies  >2 publications with SENP2 and Placenta
 Kidney Antibodies  >2 publications with SENP2 and Kidney
 Liver Antibodies  >1 publications with SENP2 and Liver
 Blood Antibodies  >1 publications with SENP2 and Blood
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