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SERPING1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS624659

SERPING1 is a highly glycosylated plasma protein involved in the regulation of the complement cascade. This protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is… More details

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Product Overview

Online Datasheet in PDF
Product Name
SERPING1, Polyclonal Antibody
Full Product Name
SERPING1, ID (Plasma Protease C1 Inhibitor, C1 Inh, C1Inh, C1 Esterase Inhibitor, C1-inhibiting Factor, C1NH, C1IN)
Product Gene Name
anti-SERPING1 antibody
Product Synonym Names
Anti -SERPING1, ID (Plasma Protease C1 Inhibitor, C1 Inh, C1Inh, C1 Esterase Inhibitor, C1-inhibiting Factor, C1NH, C1IN)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human SERPING1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
14,110 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (57365027..57382326). Location: 11q12-q13.1
3D Structure
ModBase 3D Structure for Q5UGI5
Immunogen
Synthetic peptide selected from the Center region of human SERPING1 (KLH).

Product Categories/Family for anti-SERPING1 antibody

Antibodies; Abs to Protease Inhibitors
Applications Tested/Suitable for anti-SERPING1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-SERPING1 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Western Blot (WB) of anti-SERPING1 antibody

Western blot analysis of SERPING1 antibody (Center) in Jurkat cell line lysates (35ug/lane). SERPING1 (arrow) was detected using the purified Pab.
Rabbit Anti-SERPING1 Polyclonal Antibody – Cat# MBS624659

Immunohistochemistry (IHC) of anti-SERPING1 antibody

SERPING1 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human lung tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SERPING1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-SERPING1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS624659

Immunofluorescence (IF) of anti-SERPING1 antibody

Confocal immunofluorescent analysis of SERPING1 Antibody (Center) with NCI-H292 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).
Rabbit Anti-SERPING1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS624659

Other Notes

Small volumes of anti-SERPING1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SERPING1 purchase

MBS624659 is an antibody targeting SERPING1. Also known as SERPING1, ID (Plasma Protease C1 Inhibitor, C1 Inh, C1Inh, C1 Esterase Inhibitor, C1-inhibiting Factor, C1NH, C1IN). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SERPING1. It may not necessarily be applicable to this product.

NCBI GI #
54300698
NCBI GeneID
710
UniProt Primary Accession #
Q5UGI5
UniProt Related Accession #
P05155; Q5UGI5; Q5UGI6
NCBI Official Full Name
serine/cysteine proteinase inhibitor clade G member 1 splice variant 3
NCBI Official Synonym Full Names
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
NCBI Official Symbol
SERPING1
NCBI Official Synonym Symbols
C1IN; C1NH; HAE1; HAE2; C1INH
UniProt Protein Name
Serine/cysteine proteinase inhibitor clade G member 1 splice variant 3
Protein Family
Plasma protease C1 inhibitor
UniProt Gene Name
SERPING1
UniProt Entry Name
Q5UGI5_HUMAN
NCBI Protein Information
plasma protease C1 inhibitor; serpin G1; OTTHUMP00000197003; OTTHUMP00000197004; OTTHUMP00000197007; OTTHUMP00000235286; OTTHUMP00000235287; C1-inhibiting factor; C1 esterase inhibitor; complement component 1 inhibitor; serine/cysteine proteinase inhibitor clade G member 1

NCBI Summary for SERPING1

This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq]
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UniProt Comments for SERPING1

SERPING1: a protein protease inhibitor (C1-inhibitor) that forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play an important role in regulating complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Mutations of the SERPING1 gene is associated with adult macular degeneration can also cause hereditary angioedema. Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Belongs to the serpin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11q12.1

Cellular Component: extracellular space; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding

Biological Process: negative regulation of complement activation, lectin pathway; platelet activation; fibrinolysis; platelet degranulation; blood circulation; innate immune response; blood coagulation; complement activation, classical pathway; blood coagulation, intrinsic pathway; aging

Disease: Angioedema, Hereditary, Type I; Complement Component 4, Partial Deficiency Of
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Research Articles on SERPING1

1. We did not find a significant association between SERPING1 and exudative age-related macular degeneration in our study

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SERPING1 antibody

 Reference Product  PubMed Publications
 C1S antibody  >11 publications with SERPING1 and C1S
 C1R antibody  >7 publications with SERPING1 and C1R
 MASP2 antibody  >4 publications with SERPING1 and MASP2
 MASP1 antibody  >2 publications with SERPING1 and MASP1

Pathways associated with anti-SERPING1 antibody

 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Formation Of Platelet Plug Pathway antibodies  Formation Of Platelet Plug Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Intrinsic Pathway antibodies  Intrinsic Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
 Platelet Activation Pathway antibodies  Platelet Activation Pathway Diagram

Diseases associated with anti-SERPING1 antibody

 Disease Name  Pubmed Publications
 Skin Diseases Antibodies  >93 publications with SERPING1 and Skin Diseases
 Angioedema Antibodies  >92 publications with SERPING1 and Angioedema
 Urticaria Antibodies  >91 publications with SERPING1 and Urticaria
 Edema Antibodies  >41 publications with SERPING1 and Edema
 Genetic Diseases, Inborn Antibodies  >37 publications with SERPING1 and Genetic Diseases, Inborn
 Angioedemas, Hereditary Antibodies  >37 publications with SERPING1 and Angioedemas, Hereditary
 Inflammation Antibodies  >17 publications with SERPING1 and Inflammation
 Pain Antibodies  >12 publications with SERPING1 and Pain
 Hematologic Diseases Antibodies  >10 publications with SERPING1 and Hematologic Diseases
 Neoplasms Antibodies  >7 publications with SERPING1 and Neoplasms

Organs/Tissues associated with anti-SERPING1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >55 publications with SERPING1 and Blood
 Vascular Antibodies  >16 publications with SERPING1 and Vascular
 Skin Antibodies  >16 publications with SERPING1 and Skin
 Larynx Antibodies  >9 publications with SERPING1 and Larynx
 Heart Antibodies  >5 publications with SERPING1 and Heart
 Eye Antibodies  >5 publications with SERPING1 and Eye
 Kidney Antibodies  >4 publications with SERPING1 and Kidney
 Intestine Antibodies  >4 publications with SERPING1 and Intestine
 Muscle Antibodies  >3 publications with SERPING1 and Muscle
 Liver Antibodies  >3 publications with SERPING1 and Liver
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