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SET2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6346451

SET2 is a histone methyltransferase that methylates 'Lys-36' of histone H3. H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation. This protein probably plays a role in chromatin structure modulation during elongation via… More details

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Product Overview

Online Datasheet in PDF
Product Name
SET2, Polyclonal Antibody
Full Product Name
SET2, NT (Histone-lysine N-methyltransferase SETD2, SET domain-containing protein 2, hSET2, Huntingtin-interacting protein HYPB, Huntingtin yeast partner B, Huntingtin-interacting protein 1, HIF-1, p231HBP, SETD2, HIF1, HYPB, KIAA1732' SET2) (Biotin)
Product Gene Name
anti-SET2 antibody
Product Synonym Gene Name
SETD2
Product Synonym Names
Histone-lysine N-methyltransferase SETD2; SET domain-containing protein 2; hSET2; Huntingtin-interacting protein HYPB; Huntingtin yeast partner B; Huntingtin-interacting protein 1; HIF-1; p231HBP; SETD2; HIF1; HYPB; KIAA1732' SET2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Purity/Purification
Purified by Protein G Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
2564
OMIM
phenotype 612778
3D Structure
ModBase 3D Structure for Q9BYW2
Immunogen
SET2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21~50 amino acids from the N-terminal region of human SET2.
Conjugate
Biotin
Note
Preservative Free

Product Categories/Family for anti-SET2 antibody

Antibodies; Enzymes; Methyltransferase
Applications Tested/Suitable for anti-SET2 antibody
Immunohistochemistry (IHC), ELISA (EIA), Immunofluorescence (IF), Immunocytochemistry (ICC)
Application Notes for anti-SET2 antibody
IHC: 1:50-100
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-SET2 antibody

Rega, S., et al., Mol. Cell. Neurosci. 18(1):68-79 (2001). Passani, L.A., et al., Hum. Mol. Genet. 9(14):2175-2182 (2000). Faber, P.W., et al., Hum. Mol. Genet. 7(9):1463-1474 (1998).

Other Notes

Small volumes of anti-SET2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SET2 purchase

MBS6346451 is an antibody targeting SET2. Also known as SET2, NT (Histone-lysine N-methyltransferase SETD2, SET domain-containing protein 2, hSET2, Huntingtin-interacting protein HYPB, Huntingtin yeast partner B, Huntingtin-interacting protein 1, HIF-1, p231HBP, SETD2, HIF1, HYPB, KIAA1732' SET2) (Biotin). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SET2. It may not necessarily be applicable to this product.

NCBI GI #
296452963
NCBI GeneID
29072
NCBI Accession #
Q9BYW2.3
UniProt Primary Accession #
Q9BYW2
UniProt Secondary Accession #
O75397; O75405; Q17RW8; Q5BKS9; Q5QGN2; Q69YI5; Q6IN64; Q6ZN53; Q6ZS25; Q8N3R0; Q8TCN0
UniProt Related Accession #
Q9BYW2
NCBI Official Full Name
Histone-lysine N-methyltransferase SETD2
NCBI Official Synonym Full Names
SET domain containing 2
NCBI Official Symbol
SETD2
NCBI Official Synonym Symbols
HYPB; SET2; HIF-1; HIP-1; KMT3A; HBP231; HSPC069; p231HBP
UniProt Protein Name
Histone-lysine N-methyltransferase SETD2
UniProt Synonym Protein Names
HIF-1; Huntingtin yeast partner B; Huntingtin-interacting protein 1; HIP-1; Huntingtin-interacting protein B; Lysine N-methyltransferase 3A; SET domain-containing protein 2; hSET2; p231HBP
Protein Family
Histone-lysine N-methyltransferase
UniProt Gene Name
SETD2
UniProt Synonym Gene Names
HIF1; HYPB; KIAA1732; KMT3A; SET2; HIP-1; hSET2
UniProt Entry Name
SETD2_HUMAN
NCBI Protein Information
histone-lysine N-methyltransferase SETD2; huntingtin yeast partner B; lysine N-methyltransferase 3A; huntingtin interacting protein 1; huntingtin-interacting protein B

NCBI Summary for SET2

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008]
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UniProt Comments for SET2

SETD2: Histone methyltransferase that methylates 'Lys-36' of histone H3. H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation. Probably plays a role in chromatin structure modulation during elongation via its interaction with hyperphosphorylated POLR2A. Binds DNA at promoters. May also act as a transcription activator that binds to promoters. Binds to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. Belongs to the histone-lysine methyltransferase family. SET2 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - lysine degradation; Methyltransferase, protein lysine; EC 2.1.1.43; Methyltransferase

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: nucleoplasm; chromosome

Molecular Function: protein binding; histone-lysine N-methyltransferase activity

Biological Process: pericardium development; establishment and/or maintenance of chromatin architecture; stem cell development; mismatch repair; regulation of transcription, DNA-dependent; mesoderm morphogenesis; forebrain development; neural tube closure; RNA elongation from RNA polymerase II promoter; embryonic cranial skeleton morphogenesis; morphogenesis of a branching structure; angiogenesis
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Research Articles on SET2

1. Results implicate SETD2 as a tumor suppressor gene and demonstrate that loss-of-function SETD2 mutations can facilitate the initiation and maintenance of leukemias with chromosomal translocations through a global reduction of H3K36me3.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SET2 antibody

 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 PKMTs Methylate Histone Lysines Pathway antibodies  PKMTs Methylate Histone Lysines Pathway Diagram

Diseases associated with anti-SET2 antibody

 Disease Name  Pubmed Publications
 Carcinoma, Renal Cell Antibodies  >26 publications with SET2 and Carcinoma, Renal Cell
 Adenocarcinoma Antibodies  >22 publications with SET2 and Adenocarcinoma
 Kidney Diseases Antibodies  >21 publications with SET2 and Kidney Diseases
 Leukemia Antibodies  >7 publications with SET2 and Leukemia
 Learning Disorders Antibodies  >1 publications with SET2 and Learning Disorders
 Brain Diseases Antibodies  >1 publications with SET2 and Brain Diseases
 Lung Neoplasms Antibodies  >1 publications with SET2 and Lung Neoplasms
 Lung Diseases Antibodies  >1 publications with SET2 and Lung Diseases

Organs/Tissues associated with anti-SET2 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >20 publications with SET2 and Kidney
 Blood Antibodies  >4 publications with SET2 and Blood
 Lung Antibodies  >4 publications with SET2 and Lung
 Brain Antibodies  >3 publications with SET2 and Brain
 Placenta Antibodies  >1 publications with SET2 and Placenta
 Stomach Antibodies  >1 publications with SET2 and Stomach
 Bone Antibodies  >1 publications with SET2 and Bone
 Embryonic Tissue Antibodies  >1 publications with SET2 and Embryonic Tissue
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