Rabbit Anti-SETD1A Polyclonal Antibody – Cat# MBS2561904

Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using SETD1A Polyclonal Antibody at dilution of 1:40(×200)

SETD1A Antibody – Rabbit Polyclonal

Name: SETD1A Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS2561904
Price: 160 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2561904

The protein encoded by this gene is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to generally mark… More details

$160 / 0.02 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SETD1A, Polyclonal Antibody

Full Product Name

SETD1A Polyclonal Antibody

Product Gene Name

anti-SETD1A antibody

Product Synonym Names

Histone-lysine N-methyltransferase SETD1A; HSET1A; KMT2F; Lysine N methyltransferase 2F; Lysine N-methyltransferase 2F; SET domain containing 1A; SET domain containing protein 1A; SET domain-containing protein 1A; SET1; Set1 Ash2 histone methyltransferase complex subunit SET1; Set1/Ash2 histone methyltransferase complex subunit SET1; SET1A; SET1A; SETD1A

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purity/Purification

Antigen Affinity Purification

Concentration

1.08mg/mL (lot specific)

Preparation and Storage

Store at -20 degree C. Avoid freeze/thaw cycles.

OMIM

AB002337 mRNA

3D Structure

ModBase 3D Structure for O15047

Immunogen

Synthetic peptide of human SETD1A

Conjugation

Unconjugated

Product Categories/Family for anti-SETD1A antibody

Cancer; Epigenetics and Nuclear Signaling

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-SETD1A antibody

Immunohistochemistry (IHC), ELISA (EIA)

Application Notes for anti-SETD1A antibody

IHC: 1:40-1:200
ELISA: 1:5000-1:10000

Other Notes

Small volumes of anti-SETD1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SETD1A purchase

MBS2561904 is an antibody targeting SETD1A. Also known as SETD1A Polyclonal Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SETD1A. It may not necessarily be applicable to this product.

NCBI GI #

749385041

NCBI GeneID

9739

NCBI Accession #

NM_014712.2

UniProt Primary Accession #

O15047

UniProt Related Accession #

O15047

GenBank Nucleotide #

NM_014712.2

NCBI Official Full Name

Homo sapiens SET domain containing 1A (SETD1A), mRNA

NCBI Official Synonym Full Names

SET domain containing 1A, histone lysine methyltransferase

NCBI Official Symbol

SETD1A

NCBI Official Synonym Symbols

Set1; KMT2F; Set1A

UniProt Protein Name

Histone-lysine N-methyltransferase SETD1A

UniProt Synonym Protein Names

Lysine N-methyltransferase 2F; SET domain-containing protein 1A; hSET1A; Set1/Ash2 histone methyltransferase complex subunit SET1

Protein Family

Histone-lysine N-methyltransferase

UniProt Gene Name

SETD1A

UniProt Synonym Gene Names

; hSET1A

NCBI Protein Information

histone-lysine N-methyltransferase SETD1A

UniProt Comments for SETD1A

SETD1A: Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression.

Protein type: Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: histone methyltransferase complex; nuclear chromatin; nuclear speck; nucleoplasm; nucleus

Molecular Function: beta-catenin binding; histone lysine N-methyltransferase activity (H3-K4 specific); histone-lysine N-methyltransferase activity; protein binding; transcription factor binding

Research Articles on SETD1A

1. SETD1A is essential to maintain mitosis and proliferation and its suppression unleashes the tumor suppressive effects of senescence.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SETD1A antibody

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