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SETD2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9446610

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting… More details

$435 / 0.1 mL (Biotin) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SETD2, Polyclonal Antibody
Full Product Name
SETD2 Conjugated Antibody
Product Gene Name
anti-SETD2 antibody
Product Synonym Names
HYPB; SET2; HIF-1; HIP-1; KMT3A; HBP231; HSPC069; p231HBP
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide
Specificity
The antibody detects endogenous levels of total SETD2 protein.
Preparation and Storage
Store at 4 degree C for 6 months.
Molecular Weight
175,982 Da
OMIM
phenotype 612778
3D Structure
ModBase 3D Structure for Q9BYW2
Immunogen
Fusion protein corresponding to residues near the C terminal of human SET domain containing 2
Conjugation
Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
Excitation Emission
AF350: 346nm/442nm
Applications Tested/Suitable for anti-SETD2 antibody
Most Applications
Application Notes for anti-SETD2 antibody
Suggested Dilution:
AF350 conjugated: most applications: 1:50-1:250
AF405 conjugated: most applications: 1:50-1:250
AF488 conjugated: most applications: 1:50-1:250
AF555 conjugated: most applications: 1:50-1:250
AF594 conjugated: most applications: 1:50-1:250
AF647 conjugated: most applications: 1:50-1:250
AF680 conjugated: most applications: 1:50-1:250
AF750 conjugated: most applications: 1:50-1:250
Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000

Other Notes

Small volumes of anti-SETD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SETD2 purchase

MBS9446610 is an antibody targeting SETD2. Also known as SETD2 Conjugated Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SETD2. It may not necessarily be applicable to this product.

NCBI GI #
109658483
NCBI GeneID
29072
NCBI Accession #
BC117162
UniProt Primary Accession #
Q9BYW2
UniProt Secondary Accession #
O75397; O75405; Q17RW8; Q5BKS9; Q5QGN2; Q69YI5; Q6IN64; Q6ZN53; Q6ZS25; Q8N3R0; Q8TCN0
UniProt Related Accession #
Q9BYW2
NCBI Official Full Name
Homo sapiens SET domain containing 2, mRNA
NCBI Official Synonym Full Names
SET domain containing 2
NCBI Official Symbol
SETD2
NCBI Official Synonym Symbols
LLS; HYPB; SET2; HIF-1; HIP-1; KMT3A; HBP231; HSPC069; p231HBP
UniProt Protein Name
Histone-lysine N-methyltransferase SETD2
UniProt Synonym Protein Names
HIF-1; Huntingtin yeast partner B; Huntingtin-interacting protein 1; HIP-1; Huntingtin-interacting protein B; Lysine N-methyltransferase 3A; SET domain-containing protein 2; hSET2; p231HBP
Protein Family
Histone-lysine N-methyltransferase
UniProt Gene Name
SETD2
UniProt Synonym Gene Names
HIF1; HYPB; KIAA1732; KMT3A; SET2; HIP-1; hSET2
UniProt Entry Name
SETD2_HUMAN
NCBI Protein Information
histone-lysine N-methyltransferase SETD2

UniProt Comments for SETD2

SETD2: Histone methyltransferase that methylates 'Lys-36' of histone H3. H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation. Probably plays a role in chromatin structure modulation during elongation via its interaction with hyperphosphorylated POLR2A. Binds DNA at promoters. May also act as a transcription activator that binds to promoters. Binds to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. Belongs to the histone-lysine methyltransferase family. SET2 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - lysine degradation; Methyltransferase, protein lysine; EC 2.1.1.43; Methyltransferase

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: nucleoplasm; chromosome

Molecular Function: protein binding; histone-lysine N-methyltransferase activity

Biological Process: pericardium development; establishment and/or maintenance of chromatin architecture; stem cell development; mismatch repair; regulation of transcription, DNA-dependent; mesoderm morphogenesis; forebrain development; neural tube closure; RNA elongation from RNA polymerase II promoter; embryonic cranial skeleton morphogenesis; morphogenesis of a branching structure; angiogenesis
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Research Articles on SETD2

1. This study provides evidence for HOTAIR to promote tumorigenesis via downregulating SETD2 in liver cancer stem cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SETD2 antibody

 Products by Pathway  Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram

Diseases associated with anti-SETD2 antibody

 Disease Name  Pubmed Publications
 Carcinoma, Renal Cell Antibodies  >14 publications with SETD2 and Carcinoma, Renal Cell
 Kidney Neoplasms Antibodies  >9 publications with SETD2 and Kidney Neoplasms
 Adenocarcinoma Antibodies  >9 publications with SETD2 and Adenocarcinoma
 Kidney Diseases Antibodies  >9 publications with SETD2 and Kidney Diseases
 Chromosome Aberrations Antibodies  >2 publications with SETD2 and Chromosome Aberrations
 Neoplasm Metastasis Antibodies  >2 publications with SETD2 and Neoplasm Metastasis

Organs/Tissues associated with anti-SETD2 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >10 publications with SETD2 and Kidney
 Blood Antibodies  >2 publications with SETD2 and Blood
 Placenta Antibodies  >1 publications with SETD2 and Placenta
 Embryonic Tissue Antibodies  >1 publications with SETD2 and Embryonic Tissue
 Lung Antibodies  >1 publications with SETD2 and Lung
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