• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

SGEF Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6346851

MBS6346851 is an antibody targeting SGEF. Also known as SGEF, ID (ARHGEF26, SGEF, Rho guanine nucleotide exchange factor 26, SH3 domain-containing guanine exchange factor) (MaxLight 490). Reactive in Human. Host: Rabbit. More details

$1060 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SGEF, Polyclonal Antibody
Full Product Name
SGEF, ID (ARHGEF26, SGEF, Rho guanine nucleotide exchange factor 26, SH3 domain-containing guanine exchange factor) (MaxLight 490)
Product Gene Name
anti-SGEF antibody
Product Synonym Gene Name
ARHGEF26
Product Synonym Names
ARHGEF26; SGEF; Rho guanine nucleotide exchange factor 26; SH3 domain-containing guanine exchange factor
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.
Purity/Purification
Purified by Protein A and Peptide Affinity Chromatography.
Specificity
Recognizes human SGEF.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
OMIM
617552
3D Structure
ModBase 3D Structure for Q96DR7
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 378-406 in the central terminal region of human SGEF.
Conjugate
MaxLight490
Note
Preservative Free

Product Categories/Family for anti-SGEF antibody

Antibodies; GTPase; Rab; Ras; Rho Proteins
Applications Tested/Suitable for anti-SGEF antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB), FLISA
Application Notes for anti-SGEF antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-SGEF antibody

Western Blot analysis in NCI-H460 cell line lysates (35ug/lane), usingMBS6013565. This demonstrates that MBS6013565 detected the SGEF protein (arrow).
Rabbit Anti-SGEF Polyclonal Antibody – Cat# MBS6346851

Immunohistochemistry (IHC) of anti-SGEF antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue, using MBS6013565 followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MBS6013565 for immunohistochemistry.
Rabbit Anti-SGEF Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6346851

Product References and Citations for anti-SGEF antibody

1. Yamada, S., et al. Oncogene 23(35):5901-5911(2004). 2. Ellerbroek, S.M., et al. Mol. Biol. Cell 15(7):3309-3319(2004). 3. Qi, H., et al. Endocrinology 144(5):1742-1752(2003).

Other Notes

Small volumes of anti-SGEF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SGEF. It may not necessarily be applicable to this product.

NCBI GI #
194473700
NCBI GeneID
26084
NCBI Accession #
NP_056410.3
UniProt Primary Accession #
Q96DR7
UniProt Related Accession #
Q96DR7
GenBank Nucleotide #
NP_056410.3
NCBI Official Full Name
rho guanine nucleotide exchange factor 26 isoform 1
NCBI Official Synonym Full Names
Rho guanine nucleotide exchange factor 26
NCBI Official Symbol
ARHGEF26
NCBI Official Synonym Symbols
SGEF; CSGEF; HMFN1864
UniProt Protein Name
Rho guanine nucleotide exchange factor 26
UniProt Synonym Protein Names
SH3 domain-containing guanine exchange factor
UniProt Gene Name
ARHGEF26
UniProt Synonym Gene Names
SGEF
NCBI Protein Information
rho guanine nucleotide exchange factor 26

NCBI Summary for SGEF

This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Show more

UniProt Comments for SGEF

Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.
Show more

Research Articles on SGEF

1. SGEF plays a role in activating RhoG during invadopodia disassembly

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000