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SGPP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248488

MBS248488 is an antibody targeting SGPP1. Also known as Rabbit Polyclonal to Human SGPP1. Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
SGPP1, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human SGPP1
Product Gene Name
Product Synonym Names
Anti-SGPP1 Antibody (aa12-42) IHC-plus; SGPP1; HSPPase1; HSPP1; Sphingosine-1-phosphatase 1; SPPase1; Human SGPP1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, 0.09% sodium azide
Purity/Purification
Immunoaffinity Purified
Specificity
Human SGPP1
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Molecular Weight
49,108 Da
OMIM
612826
3D Structure
ModBase 3D Structure for Q9BX95
Target Species
Human
Immunogen Description
KLH-conjugated synthetic peptide from N-terminal region of human SGPP1.
Immunogen Type
Synthetic peptide
Immunogen
SGPP1 antibody was raised against kLH-conjugated synthetic peptide from N-terminal region of human SGPP1.
Antigen Modification
aa12-42
Applications Tested/Suitable for anti-SGPP1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-SGPP1 antibody
IHC-P (1:10 - 1:100), WB (1:1000)

Immunohistochemistry (IHC) of anti-SGPP1 antibody

Anti-SGPP1 antibody IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-SGPP1 Polyclonal Antibody – Cat# MBS248488

Immunohistochemistry (IHC) of anti-SGPP1 antibody

SGPP1 Antibody (N-term) IHC of formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This demonstrates the use of SGPP1 Antibody (N-term) for immunohistochemistry.
Rabbit Anti-SGPP1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS248488

Western Blot (WB) of anti-SGPP1 antibody

SGPP1 Antibody (N-term) Western blot of NCI-H292 cell line lysates (35 ug/lane). This demonstrates the SGPP1 antibody detected the SGPP1 protein (arrow).
Rabbit Anti-SGPP1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS248488

Other Notes

Small volumes of anti-SGPP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SGPP1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
sphingosine-1-phosphate phosphatase 1
NCBI Official Synonym Full Names
sphingosine-1-phosphate phosphatase 1
NCBI Official Symbol
SGPP1
NCBI Official Synonym Symbols
SPPase1
UniProt Protein Name
Sphingosine-1-phosphate phosphatase 1
UniProt Synonym Protein Names
Sphingosine-1-phosphatase 1
UniProt Gene Name
SGPP1
UniProt Synonym Gene Names
SPPase1; Spp1; hSPP1; hSPPase1
UniProt Entry Name
SGPP1_HUMAN
NCBI Protein Information
sphingosine-1-phosphate phosphatase 1; spp1; hSPP1; hSPPase1; sphingosine-1-phosphatase 1

NCBI Summary for SGPP1

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed 10859351]; Le Stunff et al., 2007 [PubMed 17895250]).[supplied by OMIM, Jun 2009]
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UniProt Comments for SGPP1

SGPP1: Has enzymatic activity against both sphingosine 1- phosphate (S1P) and dihydro-S1P. Regulates intracellular and extracellular S1P levels. Belongs to the type 2 lipid phosphate phosphatase family.

Protein type: Mitochondrial; Motility/polarity/chemotaxis; Membrane protein, multi-pass; Endoplasmic reticulum; Apoptosis; Phosphatase (non-protein); Cytoskeletal; Lipid Metabolism - sphingolipid; Membrane protein, integral; EC 3.1.3.-

Chromosomal Location of Human Ortholog: 14q23.2

Cellular Component: endoplasmic reticulum membrane; integral to membrane

Molecular Function: sphingosine-1-phosphate phosphatase activity

Biological Process: sphinganine-1-phosphate metabolic process; sphingolipid metabolic process; sphingolipid biosynthetic process; dephosphorylation; sphingosine metabolic process
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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