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SGPP2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6347084

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP2 catalyzes the degradation of S1P (Ogawa et al., 2003 [PubMed 12411432]). More details

$1060 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SGPP2, Polyclonal Antibody
Full Product Name
SGPP2, NT (SGPP2, Sphingosine-1-phosphate phosphatase 2, Sphingosine-1-phosphatase 2) (MaxLight 650)
Product Gene Name
anti-SGPP2 antibody
Product Synonym Names
SGPP2; Sphingosine-1-phosphate phosphatase 2; Sphingosine-1-phosphatase 2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
44,741 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (223289322..223423617). Location: 2q36.1
OMIM
612827
3D Structure
ModBase 3D Structure for Q8IWX5
Immunogen
SGPP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-33 amino acids from the N-terminal region of human SGPP2.
Conjugate
MaxLight650
Note
Preservative Free

Product Categories/Family for anti-SGPP2 antibody

Antibodies; Enzymes; Phosphatase
Applications Tested/Suitable for anti-SGPP2 antibody
Western Blot (WB), FLISA
Application Notes for anti-SGPP2 antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-SGPP2 antibody

Mechtcheriakova, D., et al. Cell. Signal. 19(4):748-760(2007). Ogawa, C., et al. J. Biol. Chem. 278(2):1268-1272(2003).

Other Notes

Small volumes of anti-SGPP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SGPP2 purchase

MBS6347084 is an antibody targeting SGPP2. Also known as SGPP2, NT (SGPP2, Sphingosine-1-phosphate phosphatase 2, Sphingosine-1-phosphatase 2) (MaxLight 650). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SGPP2. It may not necessarily be applicable to this product.

NCBI GI #
23510289
NCBI GeneID
130367
NCBI Accession #
NP_689599.2
UniProt Primary Accession #
Q8IWX5
UniProt Secondary Accession #
Q8N8Q6; A3KPB4
UniProt Related Accession #
Q8IWX5
GenBank Nucleotide #
NM_152386.2
NCBI Official Full Name
sphingosine-1-phosphate phosphatase 2
NCBI Official Synonym Full Names
sphingosine-1-phosphate phosphatase 2
NCBI Official Symbol
SGPP2
NCBI Official Synonym Symbols
SPP2
UniProt Protein Name
Sphingosine-1-phosphate phosphatase 2
UniProt Synonym Protein Names
Sphingosine-1-phosphatase 2
Protein Family
Sphingosine-1-phosphate phosphatase
UniProt Gene Name
SGPP2
UniProt Synonym Gene Names
SPPase2; Spp2; hSPP2
UniProt Entry Name
SGPP2_HUMAN
NCBI Protein Information
sphingosine-1-phosphate phosphatase 2; hSPP2; SPPase2; sphingosine-1-phosphatase 2; sphingosine-1-phosphate phosphotase 2; sphingosine 1-phosphate phosphohydrolase 2

UniProt Comments for SGPP2

Function: Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling. Ref.1 Ref.4

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.1.

Tissue specificity: Expressed strongly in kidney and heart, followed by brain, colon, small intestine and lung. Not detected in skeletal muscle, thymus, spleen, liver, placenta, and peripheral blood leukocytes. Ref.1

Induction: Strongly induced by TNF, also induced by bacterial lipopolycaccharides (LPS) in neutrophils, endothelial cells, and other cell types. Not induced by growth-related factors. Ref.4

Sequence similarities: Belongs to the type 2 lipid phosphate phosphatase family.
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Research Articles on SGPP2

1. characterization of SPP2, another member of the SPP family that may play a role in attenuating intracellular S1P signaling.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SGPP2 antibody

 Reference Product  PubMed Publications
 SPHK1 antibody  >2 publications with SGPP2 and SPHK1
 SGPL1 antibody  >1 publications with SGPP2 and SGPL1

Pathways associated with anti-SGPP2 antibody

 Products by Pathway  Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid De Novo Biosynthesis Pathway antibodies  Sphingolipid De Novo Biosynthesis Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingosine And Sphingosine-1-phosphate Metabolism Pathway antibodies  Sphingosine And Sphingosine-1-phosphate Metabolism Pathway Diagram

Diseases associated with anti-SGPP2 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2 publications with SGPP2 and Inflammation
 Necrosis Antibodies  >1 publications with SGPP2 and Necrosis
 Ovarian Diseases Antibodies  >1 publications with SGPP2 and Ovarian Diseases

Organs/Tissues associated with anti-SGPP2 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >1 publications with SGPP2 and Skin
 Uterus Antibodies  >1 publications with SGPP2 and Uterus
 Embryonic Tissue Antibodies  >1 publications with SGPP2 and Embryonic Tissue
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