Rabbit Anti-SH2D2A Polyclonal Antibody – Cat# MBS6347143

SH2D2A Antibody (Center) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the SH2D2A antibody detected the SH2D2A protein (arrow).

SH2D2A Antibody – Rabbit Polyclonal

Name: SH2D2A Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6347143
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6347143

This protein encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing… More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SH2D2A, Polyclonal Antibody

Full Product Name

SH2D2A, ID (SH2D2A, SCAP, TSAD, VRAP, SH2 domain-containing protein 2A, SH2 domain-containing adapter protein, T cell-specific adapter protein, VEGF receptor-associated protein) (APC)

Product Gene Name

anti-SH2D2A antibody

Product Synonym Names

SH2D2A; SCAP; TSAD; VRAP; SH2 domain-containing protein 2A; SH2 domain-containing adapter protein; T cell-specific adapter protein; VEGF receptor-associated protein

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

40,954 Da

OMIM

604514

3D Structure

ModBase 3D Structure for Q9NP31

Immunogen

SH2D2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 94-124 amino acids from the Central region of human SH2D2A.

Conjugate

APC

Note

Preservative Free

Special Handling

Light sensitive

Product Categories/Family for anti-SH2D2A antibody

Antibodies; Receptors

Applications Tested/Suitable for anti-SH2D2A antibody

Western Blot (WB), FLISA

Application Notes for anti-SH2D2A antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-SH2D2A antibody

Trynka, G., et al. Gut 58(8):1078-1083(2009). Granum, S., et al. J. Biol. Chem. 283(32):21909-21919(2008). Lorentzen, A.R., et al. J. Neuroimmunol. 197(2):152-158(2008).

Other Notes

Small volumes of anti-SH2D2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SH2D2A purchase

MBS6347143 is an antibody targeting SH2D2A. Also known as SH2D2A, ID (SH2D2A, SCAP, TSAD, VRAP, SH2 domain-containing protein 2A, SH2 domain-containing adapter protein, T cell-specific adapter protein, VEGF receptor-associated protein) (APC). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SH2D2A. It may not necessarily be applicable to this product.

NCBI GI #

239787750

NCBI GeneID

9047

NCBI Accession #

NP_003966.2

UniProt Primary Accession #

Q9NP31

UniProt Secondary Accession #

O43817; Q5UBZ1; Q5VZS4; Q5VZS5; Q9UPA7

UniProt Related Accession #

Q9NP31

GenBank Nucleotide #

NM_003975.3

NCBI Official Full Name

SH2 domain-containing protein 2A isoform 2

NCBI Official Synonym Full Names

SH2 domain containing 2A

NCBI Official Symbol

SH2D2A

NCBI Official Synonym Symbols

SCAP; TSAD; VRAP; F2771

UniProt Protein Name

SH2 domain-containing protein 2A

UniProt Synonym Protein Names

SH2 domain-containing adapter protein; T cell-specific adapter protein; TSAd; VEGF receptor-associated protein

Protein Family

SH2 domain-containing protein

UniProt Gene Name

SH2D2A

UniProt Synonym Gene Names

SCAP; TSAD; VRAP; TSAd

UniProt Entry Name

SH22A_HUMAN

NCBI Protein Information

SH2 domain-containing protein 2A

NCBI Summary for SH2D2A

This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

UniProt Comments for SH2D2A

TSAd: an adaptor protein that may facilitate and regulate interaction of KDR with effector proteins important to endothelial cell survival and proliferation. May play a role in the CD4-p56- LCK-dependent signal transduction pathway in T cells. Could also play an important role in normal and pathological angiogenesis.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: cytoplasm; cytosol

Molecular Function: protein binding; SH3/SH2 adaptor activity; SH3 domain binding

Biological Process: cell proliferation; positive regulation of signal transduction; angiogenesis; signal transduction; cell differentiation; vascular endothelial growth factor receptor signaling pathway

Research Articles on SH2D2A

1. TSAD binds to and co-localizes with Nck. Expression of TSAD increases both Nck-Lck and Nck-SLP-76 interaction in T cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SH2D2A antibody

Reference Product	PubMed Publications
LCK antibody	>32 publications with SH2D2A and LCK
SRC antibody	>26 publications with SH2D2A and SRC
ITK antibody	>7 publications with SH2D2A and ITK
MAP3K2 antibody	>2 publications with SH2D2A and MAP3K2
TXK antibody	>1 publications with SH2D2A and TXK
SMAD2 antibody	>1 publications with SH2D2A and SMAD2
KDR antibody	>1 publications with SH2D2A and KDR

Pathways associated with anti-SH2D2A antibody

Products by Pathway	Pathway Diagram
ErbB1 Downstream Signaling Pathway antibodies	ErbB1 Downstream Signaling Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By VEGF Pathway antibodies	Signaling By VEGF Pathway Diagram
Signaling Events Mediated By VEGFR1 And VEGFR2 Pathway antibodies	Signaling Events Mediated By VEGFR1 And VEGFR2 Pathway Diagram
VEGF Signaling Pathway antibodies	VEGF Signaling Pathway Diagram
VEGF Signaling Pathway antibodies	VEGF Signaling Pathway Diagram
VEGFA-VEGFR2 Pathway antibodies	VEGFA-VEGFR2 Pathway Diagram

Diseases associated with anti-SH2D2A antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>6 publications with SH2D2A and Nervous System Diseases
Hematologic Diseases Antibodies	>2 publications with SH2D2A and Hematologic Diseases
Necrosis Antibodies	>2 publications with SH2D2A and Necrosis
Cardiovascular Diseases Antibodies	>1 publications with SH2D2A and Cardiovascular Diseases
Dermatitis Antibodies	>1 publications with SH2D2A and Dermatitis
Neoplasms, Experimental Antibodies	>1 publications with SH2D2A and Neoplasms, Experimental

Organs/Tissues associated with anti-SH2D2A antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>49 publications with SH2D2A and Blood
Thymus Antibodies	>4 publications with SH2D2A and Thymus
Spleen Antibodies	>4 publications with SH2D2A and Spleen
Lung Antibodies	>2 publications with SH2D2A and Lung
Kidney Antibodies	>1 publications with SH2D2A and Kidney
Lymph Node Antibodies	>1 publications with SH2D2A and Lymph Node
Embryonic Tissue Antibodies	>1 publications with SH2D2A and Embryonic Tissue