Rabbit Anti-SIRPB1 Polyclonal Antibody – Cat# MBS6347749

SIRPB1 Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the SIRPB1 antibody detected the SIRPB1 protein (arrow).

SIRPB1 Antibody – Rabbit Polyclonal

Name: SIRPB1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6347749
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6347749

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SIRPB1, Polyclonal Antibody

Full Product Name

SIRPB1, ID (SIRPB1, Signal-regulatory protein beta-1, CD172 antigen-like family member B, CD172b) (Biotin)

Product Gene Name

anti-SIRPB1 antibody

Product Synonym Names

SIRPB1; Signal-regulatory protein beta-1; CD172 antigen-like family member B; CD172b

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

43,211 Da

Chromosome Location

Chromosome: 20; NC_000020.10 (1545029..1600689, complement). Location: 20p13

OMIM

603889

3D Structure

ModBase 3D Structure for O00241

Immunogen

SIRPB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-134 amino acids from the Central region of human SIRPB1.

Conjugate

Biotin

Note

Preservative Free

Product Categories/Family for anti-SIRPB1 antibody

Antibodies; CD Markers

Applications Tested/Suitable for anti-SIRPB1 antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-SIRPB1 antibody

WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-SIRPB1 antibody

Gaikwad, S., et al. Am. J. Pathol. 175(6):2528-2539(2009). Martins-de-Souza, D., et al. Eur Arch Psychiatry Clin Neurosci 259(3):151-163(2009). Martins-de-Souza, D., et al. J Neural Transm 116(3):275-289(2009). Lamesch, P., et al. Genomics 89(3):307-315(2007). van den Berg, T.K., et al. J. Immunol. 175(12):7788-7789(2005).

Other Notes

Small volumes of anti-SIRPB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SIRPB1 purchase

MBS6347749 is an antibody targeting SIRPB1. Also known as SIRPB1, ID (SIRPB1, Signal-regulatory protein beta-1, CD172 antigen-like family member B, CD172b) (Biotin). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SIRPB1. It may not necessarily be applicable to this product.

NCBI GI #

144953878

NCBI GeneID

10326

NCBI Accession #

NP_001077379.1

UniProt Primary Accession #

O00241

UniProt Secondary Accession #

Q5TFQ9; Q5TFR0; Q8TB12; Q9H1U5; Q9Y4V0; A6NLM2; B2R8V0

UniProt Related Accession #

O00241; Q5TFQ8

GenBank Nucleotide #

NM_001083910.2

NCBI Official Full Name

signal-regulatory protein beta-1 isoform 2

NCBI Official Synonym Full Names

signal-regulatory protein beta 1

NCBI Official Symbol

SIRPB1

NCBI Official Synonym Symbols

CD172b; SIRP-BETA-1

UniProt Protein Name

Signal-regulatory protein beta-1

UniProt Synonym Protein Names

CD172 antigen-like family member B

Protein Family

Signal-regulatory protein

UniProt Gene Name

SIRPB1

UniProt Synonym Gene Names

SIRP-beta-1

UniProt Entry Name

SIRB1_HUMAN

NCBI Protein Information

signal-regulatory protein beta-1; CD172 antigen-like family member B

NCBI Summary for SIRPB1

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

UniProt Comments for SIRPB1

SIRPB1: Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function: protein binding

Biological Process: cell surface receptor linked signal transduction; innate immune response; signal transduction

Research Articles on SIRPB1

1. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SIRPB1 antibody

Reference Product	PubMed Publications
TYROBP antibody	>4 publications with SIRPB1 and TYROBP

Pathways associated with anti-SIRPB1 antibody

Products by Pathway	Pathway Diagram
Cell-Cell Communication Pathway antibodies	Cell-Cell Communication Pathway Diagram
DAP12 Interactions Pathway antibodies	DAP12 Interactions Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Osteoclast Differentiation Pathway antibodies	Osteoclast Differentiation Pathway Diagram
Osteoclast Differentiation Pathway antibodies	Osteoclast Differentiation Pathway Diagram
Signal Regulatory Protein (SIRP) Family Interactions Pathway antibodies	Signal Regulatory Protein (SIRP) Family Interactions Pathway Diagram

Diseases associated with anti-SIRPB1 antibody

Disease Name	Pubmed Publications
Necrosis Antibodies	>3 publications with SIRPB1 and Necrosis
Inflammation Antibodies	>2 publications with SIRPB1 and Inflammation
Alzheimer Disease Antibodies	>1 publications with SIRPB1 and Alzheimer Disease
Neoplasms Antibodies	>1 publications with SIRPB1 and Neoplasms

Organs/Tissues associated with anti-SIRPB1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>6 publications with SIRPB1 and Blood
Bone Marrow Antibodies	>1 publications with SIRPB1 and Bone Marrow
Spleen Antibodies	>1 publications with SIRPB1 and Spleen