Rabbit Anti-SIRT3 Polyclonal Antibody – Cat# MBS6347811

SIRT3 Antibody – Rabbit Polyclonal

Name: SIRT3 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6347811
Price: 1025 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6347811

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been… More details

$1025 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SIRT3, Polyclonal Antibody

Full Product Name

SIRT3, NT (SIRT3, SIR2L3, NAD-dependent protein deacetylase sirtuin-3, mitochondrial, Regulatory protein SIR2 homolog 3, SIR2-like protein 3) (MaxLight 750)

Product Gene Name

anti-SIRT3 antibody

Product Synonym Names

SIRT3; SIR2L3; NAD-dependent protein deacetylase sirtuin-3, mitochondrial; Regulatory protein SIR2 homolog 3; SIR2-like protein 3

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

28,567 Da

OMIM

604481

3D Structure

ModBase 3D Structure for Q9NTG7

Immunogen

SIRT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-84 amino acids from the N-terminal region of human SIRT3.

Conjugate

MaxLight750

Note

Preservative Free

Product Categories/Family for anti-SIRT3 antibody

Antibodies; Mitochondrial Proteins

Applications Tested/Suitable for anti-SIRT3 antibody

Western Blot (WB), FLISA

Application Notes for anti-SIRT3 antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-SIRT3 antibody

Dransfeld, C.L., et al. Int. J. Oncol. 36(4):955-960(2010). Shulga, N., et al. J. Cell. Sci. 123 (PT 6), 894-902 (2010): Shi, T., et al. J Dig Dis 11(1):55-62(2010). Kong, X., et al. PLoS ONE 5 (7), E11707 (2010): Li, S., et al. PLoS ONE 5 (5), E10486 (2010).

Other Notes

Small volumes of anti-SIRT3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SIRT3 purchase

MBS6347811 is an antibody targeting SIRT3. Also known as SIRT3, NT (SIRT3, SIR2L3, NAD-dependent protein deacetylase sirtuin-3, mitochondrial, Regulatory protein SIR2 homolog 3, SIR2-like protein 3) (MaxLight 750). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SIRT3. It may not necessarily be applicable to this product.

NCBI GI #

6912660

NCBI GeneID

23410

NCBI Accession #

NP_036371.1

NCBI Related Accession #

NP_001017524.1

UniProt Primary Accession #

Q9NTG7

UniProt Secondary Accession #

Q9Y6E8; B7Z5U6

UniProt Related Accession #

Q9NTG7

GenBank Nucleotide #

NM_012239.5

NCBI Official Full Name

NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform a

NCBI Official Synonym Full Names

sirtuin 3

NCBI Official Symbol

SIRT3

NCBI Official Synonym Symbols

SIR2L3

UniProt Protein Name

NAD-dependent protein deacetylase sirtuin-3, mitochondrial

UniProt Synonym Protein Names

Regulatory protein SIR2 homolog 3; SIR2-like protein 3

Protein Family

NAD-dependent protein deacetylase sirtuin

UniProt Gene Name

SIRT3

UniProt Synonym Gene Names

SIR2L3; hSIRT3

UniProt Entry Name

SIR3_HUMAN

NCBI Protein Information

NAD-dependent protein deacetylase sirtuin-3, mitochondrial

UniProt Comments for SIRT3

SIRT3: a soluble mitochondrial NAD-dependent protein deacetylase. Can deacetylate and thereby activate a central metabolic regulator in the mitochondrial matrix, glutamate dehydrogenase. Mitochondrial proteins are hyperacetylated in SIRT3-deficient mice, but not in SIRT4 or SIRT5 deficient mice. SIRT3-deficient mice have no obvious metabolic phenotype, and the process of adaptive thermogenesis is normal. Can deacetylate and activate isocitrate dehydrogenase 2, an enzyme that participates in regulation of the citric acid cycle and the regeneration of antioxidants. Inhibited by nicotinamide, but not by trichostatin A. Its unprocessed form is enzymatically inactive. It is processed by mitochondrial processing peptidase (MPP) in the mitochondrial matrix to give an enzymatically active 28 kDa product.

Protein type: Deacetylase; EC 3.5.1.-; Mitochondrial

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: mitochondrion; membrane; mitochondrial matrix

Molecular Function: protein binding; enzyme binding; zinc ion binding; NAD-dependent histone deacetylase activity (H3-K14 specific); NAD+ ADP-ribosyltransferase activity

Biological Process: mitochondrion organization and biogenesis; protein amino acid ADP-ribosylation; protein amino acid deacetylation; organelle organization and biogenesis; aerobic respiration; aging

Research Articles on SIRT3

1. Development of novel SIRT3 inhibitors, such as LC-0296, might enable the development of new targeted therapies to treat and improve the survival rate of patients with head and neck cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SIRT3 antibody

Reference Product	PubMed Publications
SIRT5 antibody	>59 publications with SIRT3 and SIRT5
FOXO3 antibody	>12 publications with SIRT3 and FOXO3
IDH2 antibody	>6 publications with SIRT3 and IDH2
UCP1 antibody	>4 publications with SIRT3 and UCP1
STK11 antibody	>2 publications with SIRT3 and STK11
ALDH2 antibody	>2 publications with SIRT3 and ALDH2

Pathways associated with anti-SIRT3 antibody

Products by Pathway	Pathway Diagram
Central Carbon Metabolism In Cancer Pathway antibodies	Central Carbon Metabolism In Cancer Pathway Diagram
Central Carbon Metabolism In Cancer Pathway antibodies	Central Carbon Metabolism In Cancer Pathway Diagram
Energy Metabolism Pathway antibodies	Energy Metabolism Pathway Diagram
Mitochondrial Biogenesis Pathway antibodies	Mitochondrial Biogenesis Pathway Diagram
Organelle Biogenesis And Maintenance Pathway antibodies	Organelle Biogenesis And Maintenance Pathway Diagram
Signaling Events Mediated By HDAC Class I Pathway antibodies	Signaling Events Mediated By HDAC Class I Pathway Diagram
Signaling Events Mediated By HDAC Class III Pathway antibodies	Signaling Events Mediated By HDAC Class III Pathway Diagram
Transcriptional Activation Of Mitochondrial Biogenesis Pathway antibodies	Transcriptional Activation Of Mitochondrial Biogenesis Pathway Diagram

Diseases associated with anti-SIRT3 antibody

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>36 publications with SIRT3 and Cardiovascular Diseases
Fatty Liver Antibodies	>21 publications with SIRT3 and Fatty Liver
Inflammation Antibodies	>19 publications with SIRT3 and Inflammation
Liver Diseases Antibodies	>19 publications with SIRT3 and Liver Diseases
Hypertrophy Antibodies	>17 publications with SIRT3 and Hypertrophy
Disease Models, Animal Antibodies	>17 publications with SIRT3 and Disease Models, Animal
Breast Neoplasms Antibodies	>11 publications with SIRT3 and Breast Neoplasms
Cardiomegaly Antibodies	>9 publications with SIRT3 and Cardiomegaly
Hypertension Antibodies	>8 publications with SIRT3 and Hypertension
Carcinoma, Squamous Cell Antibodies	>8 publications with SIRT3 and Carcinoma, Squamous Cell

Organs/Tissues associated with anti-SIRT3 antibody

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>64 publications with SIRT3 and Muscle
Heart Antibodies	>48 publications with SIRT3 and Heart
Blood Antibodies	>32 publications with SIRT3 and Blood
Adipose Tissue Antibodies	>25 publications with SIRT3 and Adipose Tissue
Brain Antibodies	>17 publications with SIRT3 and Brain
Connective Tissue Antibodies	>16 publications with SIRT3 and Connective Tissue
Kidney Antibodies	>14 publications with SIRT3 and Kidney
Lung Antibodies	>10 publications with SIRT3 and Lung
Pancreas Antibodies	>6 publications with SIRT3 and Pancreas
Prostate Antibodies	>5 publications with SIRT3 and Prostate