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SLC19A1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3207243

This is a rabbit polyclonal antibody against SLC19A1. It was validated on Western Blot and immunohistochemistryTarget Description: Transport of folate compounds into mammalian cells can occur via receptor-mediated or carrier-mediated mechanisms. A functional… More details

$440 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
SLC19A1, Polyclonal Antibody
Full Product Name
SLC19A1 antibody - N-terminal region
Product Gene Name
anti-SLC19A1 antibody
Product Synonym Gene Name
CHMD; FOLT; IFC1; REFC; RFC1
Immunogen Sequence
Synthetic peptide located within the following region: MVPSSPAVEK QVPVEPGPDP ELRSWRHLVC YLCFYGFMAQ IRPGESFITP
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Protein A purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
SLC19A1 peptide (MBS3232208) is used for blocking the activity of SLC19A1 antibody (MBS3207243)
Molecular Weight
65kDa
OMIM
600424
3D Structure
ModBase 3D Structure for P41440
Homology
Human: 100%
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human SLC19A1

Product Categories/Family for anti-SLC19A1 antibody

Polyclonal; Membrane Protein; Drugs and Drug Metabolism; Immunohistochemistry
Applications Tested/Suitable for anti-SLC19A1 antibody
Immunohistochemistry (IHC), Western Blot (WB)

Immunohistochemistry (IHC) of anti-SLC19A1 antibody

Human kidney
Rabbit Anti-SLC19A1 Polyclonal Antibody – Cat# MBS3207243

Western Blot (WB) of anti-SLC19A1 antibody

WB Suggested Anti-SLC19A1 Antibody Titration: 5.0ug/ml
Positive Control: Jurkat cell lysateSLC19A1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells
Rabbit Anti-SLC19A1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3207243

Other Notes

Small volumes of anti-SLC19A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SLC19A1 purchase

MBS3207243 is an antibody targeting SLC19A1. Also known as SLC19A1 antibody - N-terminal region. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC19A1. It may not necessarily be applicable to this product.

NCBI GI #
34808710
NCBI GeneID
6573
NCBI Accession #
NP_919231
UniProt Primary Accession #
P41440
UniProt Related Accession #
P41440
GenBank Nucleotide #
NM_194255
NCBI Official Full Name
folate transporter 1 isoform 1
NCBI Official Synonym Full Names
solute carrier family 19 member 1
NCBI Official Symbol
SLC19A1
NCBI Official Synonym Symbols
RFC; CHMD; FOLT; IFC1; REFC; RFC1; IFC-1
UniProt Protein Name
Folate transporter 1
UniProt Synonym Protein Names
Intestinal folate carrier 1; IFC-1; Placental folate transporter; Reduced folate carrier protein; RFC; Solute carrier family 19 member 1
UniProt Gene Name
SLC19A1
UniProt Synonym Gene Names
FLOT1; RFC1; FOLT; IFC-1; RFC
UniProt Entry Name
S19A1_HUMAN
NCBI Protein Information
folate transporter 1

NCBI Summary for SLC19A1

The membrane protein encoded by this gene is a transporter of folate and is involved in the regulation of intracellular concentrations of folate. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]

UniProt Comments for SLC19A1

SLC19A1: a transporter protein. Transports reduced folate, antitumor agents and folate antagonists such as methotrexate. Apparently involved in methotrexate resistance in various cancers and neural tube defects.

Protein type: Transporter, SLC family; Membrane protein, multi-pass; Transporter; Membrane protein, integral

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: apical plasma membrane; basolateral plasma membrane; brush border membrane; integral to plasma membrane; plasma membrane

Molecular Function: folic acid binding; folic acid transporter activity; methotrexate transporter activity; reduced folate carrier activity

Biological Process: female pregnancy; folic acid metabolic process; folic acid transport; methotrexate transport
Show more

Research Articles on SLC19A1

1. miR-595 acts as a phenotypic regulator of methotrexate sensitivity in CEM/C1 cells by targeting SLC19A1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SLC19A1 antibody

 Reference Product  PubMed Publications
 MTHFR antibody  >122 publications with SLC19A1 and MTHFR
 MTRR antibody  >38 publications with SLC19A1 and MTRR
 FPGS antibody  >34 publications with SLC19A1 and FPGS
 SLC46A1 antibody  >31 publications with SLC19A1 and SLC46A1
 MTHFD1 antibody  >23 publications with SLC19A1 and MTHFD1
 GGH antibody  >22 publications with SLC19A1 and GGH
 TP53 antibody  >4 publications with SLC19A1 and TP53
 TPMT antibody  >4 publications with SLC19A1 and TPMT
 UBC antibody  >2 publications with SLC19A1 and UBC

Pathways associated with anti-SLC19A1 antibody

 Products by Pathway  Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Folate And Pterines Pathway antibodies  Metabolism Of Folate And Pterines Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Metabolism Of Water-soluble Vitamins And Cofactors Pathway antibodies  Metabolism Of Water-soluble Vitamins And Cofactors Pathway Diagram
 Vitamin Digestion And Absorption Pathway antibodies  Vitamin Digestion And Absorption Pathway Diagram
 Vitamin Digestion And Absorption Pathway antibodies  Vitamin Digestion And Absorption Pathway Diagram

Diseases associated with anti-SLC19A1 antibody

 Disease Name  Pubmed Publications
 Neoplasms, Experimental Antibodies  >64 publications with SLC19A1 and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >62 publications with SLC19A1 and Nervous System Diseases
 Congenital Abnormalities Antibodies  >58 publications with SLC19A1 and Congenital Abnormalities
 Precursor Cell Lymphoblastic Leukemia-Lymphoma Antibodies  >42 publications with SLC19A1 and Precursor Cell Lymphoblastic Leukemia-Lymphoma
 Neural Tube Defects Antibodies  >38 publications with SLC19A1 and Neural Tube Defects
 Cardiovascular Diseases Antibodies  >32 publications with SLC19A1 and Cardiovascular Diseases
 Lung Neoplasms Antibodies  >28 publications with SLC19A1 and Lung Neoplasms
 Breast Neoplasms Antibodies  >24 publications with SLC19A1 and Breast Neoplasms
 Colorectal Neoplasms Antibodies  >22 publications with SLC19A1 and Colorectal Neoplasms
 Disease Models, Animal Antibodies  >19 publications with SLC19A1 and Disease Models, Animal

Organs/Tissues associated with anti-SLC19A1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >30 publications with SLC19A1 and Brain
 Heart Antibodies  >18 publications with SLC19A1 and Heart
 Bone Antibodies  >17 publications with SLC19A1 and Bone
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