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SLC30A10 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9201799

Zinc functions as a cofactor for numerous enzymes, nuclearfactors, and hormones and as an intra- and intercellular signalion. Members of the zinc transporter (ZNT)/SLC30 subfamily of thecation diffusion facilitator family, such as SLC30A10, permitcellular… More details

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Product Overview

Online Datasheet in PDF
Product Name
SLC30A10, Polyclonal Antibody
Full Product Name
SLC30A10 Antibody (C-term)
Product Gene Name
Product Synonym Names
Zinc transporter 10; ZnT-10; Solute carrier family 30 member 10; SLC30A10; ZNT10; ZNT8
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Concentration
Vial Concentration: 0.5 (lot specific)
Specificity
This SLC30A10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 331-359 amino acids from the C-terminal region of human SLC30A10.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
Molecular Weight
52684
Immunogen Sequence Positions
331-359
OMIM
611146
3D Structure
ModBase 3D Structure for Q6XR72
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Function
Plays a pivotal role in manganese transp ort. Manganese is an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways.
Cellular Location
Cell membrane; Multi-pass membrane protein
Tissue Location
Specifically expressed in fetal liver and fetal brain.

Product Categories/Family for anti-SLC30A10 antibody

Applications Tested/Suitable for anti-SLC30A10 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-SLC30A10 antibody
WB~~1:1000

Western Blot (WB) of anti-SLC30A10 antibody

SLC30A10 Antibody (C-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the SLC30A10 antibody detected the SLC30A10 protein (arrow).
Rabbit Anti-SLC30A10 Polyclonal Antibody – Cat# MBS9201799

Western Blot of anti-SLC30A10 antibody

Anti-SLC30A10 Antibody (C-term) at 1:2000 dilution + human liver lysate Lysates/proteins at 20 ?g per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 53 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Rabbit Anti-SLC30A10 Polyclonal Antibody, Western Blot – Cat# MBS9201799

Western Blot of anti-SLC30A10 antibody

All lanes : Anti-SLC30A10 Antibody (C-term) at 1:2000 dilution Lane 1: human fetal brain lysate Lane 2: human fetal liver lysate Lysates/proteins at 20 ?g per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 53 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Rabbit Anti-SLC30A10 Polyclonal Antibody, Western Blot – Cat# MBS9201799

Product References and Citations for anti-SLC30A10 antibody

Wang, L., et al. Cancer Epidemiol. Biomarkers Prev. 17(12):3558-3566(2008)
Seve, M., et al. BMC Genomics 5 (1), 32 (2004) :

Other Notes

Small volumes of anti-SLC30A10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SLC30A10 purchase

MBS9201799 is an antibody targeting SLC30A10. Also known as SLC30A10 Antibody (C-term). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC30A10. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
zinc transporter 10
NCBI Official Synonym Full Names
solute carrier family 30, member 10
NCBI Official Symbol
SLC30A10
NCBI Official Synonym Symbols
ZNT8; ZRC1; HMDPC; ZNT10; ZnT-10
UniProt Protein Name
Zinc transporter 10
UniProt Synonym Protein Names
Solute carrier family 30 member 10
Protein Family
UniProt Gene Name
SLC30A10
UniProt Synonym Gene Names
ZNT10; ZNT8; ZnT-10
UniProt Entry Name
ZNT10_HUMAN
NCBI Protein Information
zinc transporter 10

NCBI Summary for SLC30A10

This gene is highly expressed in the liver and is inducible by manganese. Its protein product appears to be critical in maintaining manganese levels, and has higher specificity for manganese than zinc. Loss of function mutations appear to result in a pleomorphic phenotype, including dystonia and adult-onset parkinsonism. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]
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UniProt Comments for SLC30A10

SLC30A10: May be involved in zinc transport out of the cell, being a zinc-efflux transporter. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, SLC family; Transporter; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1q41

Cellular Component: integral to membrane; plasma membrane

Molecular Function: cation transmembrane transporter activity

Biological Process: manganese ion transport; zinc ion transport

Disease: Hypermanganesemia With Dystonia, Polycythemia, And Cirrhosis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-SLC30A10 antibody

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