Rabbit Anti-SLC4A4 Polyclonal Antibody – Cat# MBS3219594

Host: Rabbit
Target Name: SLC4A4
Sample Tissue: Human PANC1 Whole Cell lysates
Antibody Dilution: 1ug/ml

SLC4A4 Antibody – Rabbit Polyclonal

Name: SLC4A4 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS3219594
Price: 490 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3219594

This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants… More details

$490 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SLC4A4, Polyclonal Antibody

Full Product Name

SLC4A4 Antibody - N-terminal region

Product Gene Name

anti-SLC4A4 antibody

Product Synonym Gene Name

KNBC; NBC1; NBC2; pNBC; HNBC1; hhNMC; SLC4A5; NBCe1-A

Immunogen Sequence

Synthetic peptide located within the following region: AVLDRGASFL KHVCDEEEVE GHHTIYIGVH VPKSYRRRRR HKRKTGHKEK

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human

Form/Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Purity/Purification

Affinity purified

Preparation and Storage

For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Antibody/Peptide Pairs

SLC4A4 peptide (MBS3244468) is used for blocking the activity of SLC4A4 antibody (MBS3219594)

Molecular Weight

109 kDa

OMIM

603345

3D Structure

ModBase 3D Structure for Q9Y6R1

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human SLC4A4

Product Categories/Family for anti-SLC4A4 antibody

Polyclonal; Cell Biology; Disease Related

Applications Tested/Suitable for anti-SLC4A4 antibody

Western Blot (WB)

Other Notes

Small volumes of anti-SLC4A4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SLC4A4 purchase

MBS3219594 is an antibody targeting SLC4A4. Also known as SLC4A4 Antibody - N-terminal region. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC4A4. It may not necessarily be applicable to this product.

NCBI GI #

8886015

NCBI GeneID

8671

NCBI Accession #

AF157492_1

UniProt Primary Accession #

Q9Y6R1

UniProt Related Accession #

Q9Y6R1

GenBank Nucleotide #

NM_001098484.2

NCBI Official Full Name

sodium bicarbonate cotransporter NBC1

NCBI Official Synonym Full Names

solute carrier family 4 member 4

NCBI Official Symbol

SLC4A4

NCBI Official Synonym Symbols

KNBC; NBC1; NBC2; pNBC; HNBC1; hhNMC; kNBC1; SLC4A5; NBCe1-A

UniProt Protein Name

Electrogenic sodium bicarbonate cotransporter 1

UniProt Synonym Protein Names

Na(+)/HCO3(-) cotransporter; Solute carrier family 4 member 4; kNBC1

Protein Family

Electrogenic sodium bicarbonate cotransporter

UniProt Gene Name

SLC4A4

UniProt Synonym Gene Names

NBC; NBC1; NBCE1; Sodium bicarbonate cotransporter

UniProt Entry Name

S4A4_HUMAN

NCBI Protein Information

electrogenic sodium bicarbonate cotransporter 1

UniProt Comments for SLC4A4

SLC4A4: Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. Defects in SLC4A4 are the cause of proximal renal tubular acidosis with ocular abnormalities (pRTA-OA); also known as renal tubular acidosis II. Caused by an impairment of bicarbonate absorption in the proximal tubule, proximal renal tubular acidosis (pRTA) is characterized by a decreased renal HCO3(-) threshold. pRTA-OA is an extremely rare autosomal recessive syndrome characterized by short stature, profound pRTA, mental retardation, bilateral glaucoma, cataracts and bandkeratopathy. Loss of interaction with and stimulation by CA4 is the cause of retinitis pigmentosa type 17 (RP17). Belongs to the anion exchanger (TC 2.A.31) family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter; Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: basolateral plasma membrane; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; inorganic anion exchanger activity; sodium:bicarbonate symporter activity

Biological Process: transport; bicarbonate transport; regulation of intracellular pH; ion transport; transmembrane transport

Disease: Renal Tubular Acidosis, Proximal, With Ocular Abnormalities And Mental Retardation

Research Articles on SLC4A4

1. A novel mechanism for variable phenotypic expressivity in band-shaped corneal dystrophy mediated by an AU-rich element (ARE)-creating mutation in SLC4A4 in three unrelated consanguineous families has been described.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.