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SLK Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3901066

Ste20-like kinase (SLK) plays a role in cytoskeletal organization during cell spreading and can induce actin stress fiber disassembly. SLK is a serine/threonine kinase that is thought to be regulated by casein kinase 2 (CK2) and is also involved in apoptosis. More details

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Product Overview

Online Datasheet in PDF
Product Name
SLK, Polyclonal Antibody
Full Product Name
Rabbit anti-SLK Antibody, Affinity Purified
Product Gene Name
anti-SLK antibody
Product Synonym Names
SNF1 sucrose nonfermenting like kinase; Long Ste20-like Kinase; STE20-related serine/threonine-protein kinase; Ste20-related serine/threonine kinase; STE20-related kinase; STE20-like serine/threonine-protein kinase; STK2; STE20-like kinase; SNF1 (sucrose nonfermenting, yeast, homolog)-like kinase, SNF1 sucrose nonfermenting like kinase; serine/threonine-protein kinase 2; LOSK; hSLK; CTCL tumor antigen se20-9; bA16H23.1; se20-9; STE20-like serine/threonine-protein kinase; STE20 like kinase
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Whole IgG. Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
1000ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
Molecular Weight
142,695 Da
Chromosome Location
Chromosome: 10; NC_000010.10 (105727470..105787342). Location: 10q24.33
3D Structure
ModBase 3D Structure for Q9H2G2
Predicted Reactivity
Mouse, Rat
Immunogen
Between 1 and 50
Conjugation
Unconjugated

Product Categories/Family for anti-SLK antibody

Primary Antibodies
Applications Tested/Suitable for anti-SLK antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-SLK antibody
WB: 1:500-1:5000
IP: 6ug/mg lysate

Western Blot (WB) of anti-SLK antibody

Detection of human SLK by western blot and immunoprecipitation. Samples: A) Whole cell lysate from MCF-7 (5, 15 and 50 ug), HeLa (H; 15 ug) and HEK293T (T; 15 ug). B) Whole cell lysate (1 mg/IP; 1/4 of IP loaded) from MCF7 cells. Antibodies: Affinity purified rabbit anti-SLK antibody BL1915 (Cat. No. MBS3901066) used at 1 ug/ml for WB (A and B) and at 3 ug/mg lysate for IP (B). SLK was also efficiently immunoprecipitated by BL1917 (Cat. No. MBS3901067) but not by BL1916. Detection: Chemiluminescence with an exposure time of 3 minutes (A and B).
Rabbit Anti-SLK Polyclonal Antibody – Cat# MBS3901066

Other Notes

Small volumes of anti-SLK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SLK purchase

MBS3901066 is an antibody targeting SLK. Also known as Rabbit anti-SLK Antibody, Affinity Purified. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SLK. It may not necessarily be applicable to this product.

NCBI GI #
41281453
NCBI GeneID
9748
NCBI Accession #
NP_055535.2
UniProt Primary Accession #
Q9H2G2
UniProt Secondary Accession #
O00211; Q6P1Z4; Q86WU7; Q86WW1; Q92603; Q9NQL0; Q9NQL1; D3DRA0; D3DRA1
UniProt Related Accession #
Q9H2G2
GenBank Nucleotide #
NM_014720.2
NCBI Official Full Name
STE20-like serine/threonine-protein kinase
NCBI Official Synonym Full Names
STE20-like kinase
NCBI Official Symbol
SLK
NCBI Official Synonym Symbols
LOSK; STK2; se20-9; bA16H23.1
UniProt Protein Name
STE20-like serine/threonine-protein kinase
UniProt Synonym Protein Names
CTCL tumor antigen se20-9; STE20-related serine/threonine-protein kinase; STE20-related kinase; Serine/threonine-protein kinase 2
Protein Family
STE20-like serine/threonine-protein kinase
UniProt Gene Name
SLK
UniProt Synonym Gene Names
KIAA0204; STK2; STE20-like kinase; hSLK
UniProt Entry Name
SLK_HUMAN
NCBI Protein Information
STE20-like serine/threonine-protein kinase; hSLK; STE20-related kinase; Long Ste20-like Kinase; CTCL tumor antigen se20-9; serine/threonine-protein kinase 2; Ste20-related serine/threonine kinase; SNF1 sucrose nonfermenting like kinase; STE20-related seri

UniProt Comments for SLK

SLK: a microtubule-associated protein kinase required for progression through G2. Co-localizes with the mitotic spindle in cells undergoing mitosis. Regulates actin reorganization during cell adhesion and spreading via a Rac1-mediated pathway. Signals via ASK1 and p38 to promote apoptosis. Activated in response to anoxia and ischemia-reperfusion injury in cell culture. It inhibits the protective aspects of the endoplasmic reticulum stress response, thus contributing to its proapoptotic effect. Two alternatively-spliced isoforms have been described.

Protein type: Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; STE group; STE20 family; SLK subfamily

Chromosomal Location of Human Ortholog: 10q24.33

Cellular Component: cytoplasm

Molecular Function: protein serine/threonine kinase activity; identical protein binding; protein homodimerization activity; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: apoptosis; protein amino acid autophosphorylation
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Research Articles on SLK

1. It was shown that lymphocyte-oriented and STE20 kinase were sufficient to restrict ezrin function to the apical domain. Both kinases were enriched in microvilli and locally activated there.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SLK antibody

 Reference Product  PubMed Publications
 CLSTN1 antibody  >1 publications with SLK and CLSTN1
 CASP3 antibody  >1 publications with SLK and CASP3

Pathways associated with anti-SLK antibody

 Products by Pathway  Pathway Diagram
 Oocyte Meiosis Pathway antibodies  Oocyte Meiosis Pathway Diagram
 Oocyte Meiosis Pathway antibodies  Oocyte Meiosis Pathway Diagram

Diseases associated with anti-SLK antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >65 publications with SLK and Neoplasms
 Kidney Diseases Antibodies  >25 publications with SLK and Kidney Diseases
 Cardiovascular Diseases Antibodies  >24 publications with SLK and Cardiovascular Diseases
 Genital Diseases, Male Antibodies  >21 publications with SLK and Genital Diseases, Male
 Liver Diseases Antibodies  >16 publications with SLK and Liver Diseases
 Inflammation Antibodies  >12 publications with SLK and Inflammation
 Kidney Neoplasms Antibodies  >10 publications with SLK and Kidney Neoplasms
 Nervous System Diseases Antibodies  >10 publications with SLK and Nervous System Diseases
 Acute Kidney Injury Antibodies  >7 publications with SLK and Acute Kidney Injury
 Hepatitis Antibodies  >7 publications with SLK and Hepatitis

Organs/Tissues associated with anti-SLK antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >53 publications with SLK and Kidney
 Blood Antibodies  >46 publications with SLK and Blood
 Eye Antibodies  >32 publications with SLK and Eye
 Liver Antibodies  >31 publications with SLK and Liver
 Prostate Antibodies  >25 publications with SLK and Prostate
 Vascular Antibodies  >18 publications with SLK and Vascular
 Nerve Antibodies  >15 publications with SLK and Nerve
 Bladder Antibodies  >14 publications with SLK and Bladder
 Brain Antibodies  >12 publications with SLK and Brain
 Lymph Antibodies  >10 publications with SLK and Lymph
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