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SNAP25 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6003377

Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex… More details

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Product Overview

Online Datasheet in PDF
Product Name
SNAP25, Polyclonal Antibody
Full Product Name
SNAP25, ID (SNAP25, SNAP, Synaptosomal-associated protein 25, Super protein, Synaptosomal-associated 25kD protein)
Product Gene Name
anti-SNAP25 antibody
Product Synonym Names
Anti -SNAP25, ID (SNAP25, SNAP, Synaptosomal-associated protein 25, Super protein, Synaptosomal-associated 25kD protein)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Purified by Protein A affinity chromatography.
Concentration
0.57 mg/mL (lot specific)
Specificity
Recognizes human SNAP25.
Preparation and Storage
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Chromosome Location
Chromosome: 20; NC_000020.10 (10199477..10288068). Location: 20p12-p11.2
OMIM
600322
3D Structure
ModBase 3D Structure for P60880
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 36-63 in the central region of human SNAP25. Species sequence homology: Zebrafish, bovine, chicken, mouse, rat.

Product Categories/Family for anti-SNAP25 antibody

Antibodies; Abs to Neuroscience
Applications Tested/Suitable for anti-SNAP25 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-SNAP25 antibody
Western Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Other applications have not been tested.

Western Blot (WB) of anti-SNAP25 antibody

Western Blot analysis of SH-SY5Y whole cell lysate (20ug/lane) using MBS6003377 (1:1000).
Secondary: IgG (H+L) (HRP) goat anti-rabbit (1:10,000). Predicted band size: 23kD.
Blocking/Dilution Buffer: 5% NFDM/TBST
Rabbit Anti-SNAP25 Polyclonal Antibody – Cat# MBS6003377

Other Notes

Small volumes of anti-SNAP25 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SNAP25 purchase

MBS6003377 is an antibody targeting SNAP25. Also known as SNAP25, ID (SNAP25, SNAP, Synaptosomal-associated protein 25, Super protein, Synaptosomal-associated 25kD protein). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SNAP25. It may not necessarily be applicable to this product.

NCBI GI #
18765735
NCBI GeneID
6616
NCBI Accession #
NP_003072.2
UniProt Primary Accession #
P60880
UniProt Secondary Accession #
P13795; P36974; P70557; P70558; Q53EM2; Q5U0B5; Q8IXK3; Q96FM2; B2RAU4; D3DW16; D3DW17
UniProt Related Accession #
P60880
GenBank Nucleotide #
NM_130811.2
NCBI Official Full Name
synaptosomal-associated protein 25 isoform SNAP25B
NCBI Official Synonym Full Names
synaptosomal-associated protein, 25kDa
NCBI Official Symbol
SNAP25
NCBI Official Synonym Symbols
RIC4; SEC9; SNAP; RIC-4; SNAP-25; bA416N4.2; dJ1068F16.2
UniProt Protein Name
Synaptosomal-associated protein 25
UniProt Synonym Protein Names
Super protein; SUP; Synaptosomal-associated 25 kDa protein
Protein Family
Synaptosomal-associated protein
UniProt Gene Name
SNAP25
UniProt Synonym Gene Names
SNAP; SNAP-25; SUP
UniProt Entry Name
SNP25_HUMAN
NCBI Protein Information
synaptosomal-associated protein 25; SUP; super protein; resistance to inhibitors of cholinesterase 4 homolog

UniProt Comments for SNAP25

SNAP-25: a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Part of the SNARE core complex containing SNAP25, VAMP2 and syntaxin 1A. Associates with proteins involved in vesicle docking and membrane fusion. Two alternatively spliced isoforms have been described.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 20p12-p11.2

Cellular Component: presynaptic membrane; SNARE complex; neuron projection; growth cone; membrane; perinuclear region of cytoplasm; cytoplasm; plasma membrane; trans-Golgi network; cytosol; cell junction; vesicle

Molecular Function: SNAP receptor activity; protein binding; syntaxin-1 binding; calcium-dependent protein binding

Biological Process: synaptic vesicle fusion to presynaptic membrane; synaptic transmission; synaptic vesicle exocytosis; glutamate secretion; neurotransmitter secretion; energy reserve metabolic process; neurotransmitter uptake; pathogenesis; synaptic vesicle priming; regulation of insulin secretion; synaptic vesicle docking during exocytosis

Disease: Myasthenic Syndrome, Congenital, 18
Show more

Research Articles on SNAP25

1. Significant associations between two SNPs in the SNAP-25 gene (rs363039 and rs363050) and shyness was found.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SNAP25 antibody

 Products by Pathway  Pathway Diagram
 Acetylcholine Neurotransmitter Release Cycle Pathway antibodies  Acetylcholine Neurotransmitter Release Cycle Pathway Diagram
 BoNT Light Chain Types A, C1, E Cleave SNAP-25 Pathway antibodies  BoNT Light Chain Types A, C1, E Cleave SNAP-25 Pathway Diagram
 Botulinum Neurotoxicity Pathway antibodies  Botulinum Neurotoxicity Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Dopamine Neurotransmitter Release Cycle Pathway antibodies  Dopamine Neurotransmitter Release Cycle Pathway Diagram
 Effects Of Botulinum Toxin Pathway antibodies  Effects Of Botulinum Toxin Pathway Diagram
 GABA Synthesis, Release, Reuptake And Degradation Pathway antibodies  GABA Synthesis, Release, Reuptake And Degradation Pathway Diagram
 Glutamate Neurotransmitter Release Cycle Pathway antibodies  Glutamate Neurotransmitter Release Cycle Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Insulin Secretion Pathway antibodies  Insulin Secretion Pathway Diagram

Diseases associated with anti-SNAP25 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >117 publications with SNAP25 and Nervous System Diseases
 Paralysis Antibodies  >21 publications with SNAP25 and Paralysis
 Cognition Disorders Antibodies  >17 publications with SNAP25 and Cognition Disorders
 Pain Antibodies  >15 publications with SNAP25 and Pain
 Memory Disorders Antibodies  >15 publications with SNAP25 and Memory Disorders
 Movement Disorders Antibodies  >13 publications with SNAP25 and Movement Disorders
 Seizures Antibodies  >12 publications with SNAP25 and Seizures
 Neurobehavioral Manifestations Antibodies  >12 publications with SNAP25 and Neurobehavioral Manifestations
 Learning Disorders Antibodies  >12 publications with SNAP25 and Learning Disorders
 Diabetes Mellitus Antibodies  >10 publications with SNAP25 and Diabetes Mellitus

Organs/Tissues associated with anti-SNAP25 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >649 publications with SNAP25 and Nerve
 Brain Antibodies  >419 publications with SNAP25 and Brain
 Pancreas Antibodies  >52 publications with SNAP25 and Pancreas
 Muscle Antibodies  >45 publications with SNAP25 and Muscle
 Embryonic Tissue Antibodies  >45 publications with SNAP25 and Embryonic Tissue
 Eye Antibodies  >34 publications with SNAP25 and Eye
 Ganglia Antibodies  >27 publications with SNAP25 and Ganglia
 Pituitary Gland Antibodies  >22 publications with SNAP25 and Pituitary Gland
 Kidney Antibodies  >17 publications with SNAP25 and Kidney
 Adrenal Gland Antibodies  >15 publications with SNAP25 and Adrenal Gland
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