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SNIP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9445936

Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in… More details

$435 / 0.1 mL (Biotin) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SNIP, Polyclonal Antibody
Full Product Name
SNIP Conjugated Antibody
Product Gene Name
anti-SNIP antibody
Product Synonym Names
p130Cas-associated protein; P140; p140Cap; SNAP-25-interacting protein
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide
Specificity
The antibody detects endogenous levels of total SNIP protein.
Preparation and Storage
Store at 4 degree C for 6 months.
Molecular Weight
112,453 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (36686259..36762183, complement). Location: 17q12
OMIM
610786
3D Structure
ModBase 3D Structure for Q9C0H9
Immunogen
Synthesized peptide derived from internal of human SNIP.
Conjugation
Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
Excitation Emission
AF350: 346nm/442nm
Applications Tested/Suitable for anti-SNIP antibody
Most Applications
Application Notes for anti-SNIP antibody
Suggested Dilution:
AF350 conjugated: most applications: 1:50-1:250
AF405 conjugated: most applications: 1:50-1:250
AF488 conjugated: most applications: 1:50-1:250
AF555 conjugated: most applications: 1:50-1:250
AF594 conjugated: most applications: 1:50-1:250
AF647 conjugated: most applications: 1:50-1:250
AF680 conjugated: most applications: 1:50-1:250
AF750 conjugated: most applications: 1:50-1:250
Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000

Other Notes

Small volumes of anti-SNIP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SNIP purchase

MBS9445936 is an antibody targeting SNIP. Also known as SNIP Conjugated Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SNIP. It may not necessarily be applicable to this product.

NCBI GI #
115334682
NCBI GeneID
80725
NCBI Accession #
NP_079524.2
UniProt Primary Accession #
Q9C0H9
UniProt Secondary Accession #
Q75T46; Q8N4W8
UniProt Related Accession #
Q9C0H9
GenBank Nucleotide #
NM_025248.2
NCBI Official Full Name
SRC kinase signaling inhibitor 1
NCBI Official Synonym Full Names
SRC kinase signaling inhibitor 1
NCBI Official Symbol
SRCIN1
NCBI Official Synonym Symbols
P140; SNIP
UniProt Protein Name
SRC kinase signaling inhibitor 1
UniProt Synonym Protein Names
SNAP-25-interacting protein; SNIP; p130Cas-associated protein; p140Cap
Protein Family
SRC kinase signaling inhibitor
UniProt Gene Name
SRCIN1
UniProt Synonym Gene Names
KIAA1684; P140; SNIP
UniProt Entry Name
SRCN1_HUMAN
NCBI Protein Information
SRC kinase signaling inhibitor 1; p140Cap; P130Cas-associated protein; SNAP25-interacting protein; SNAP-25-interacting protein

UniProt Comments for SNIP

SNIP: Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance. Interacts with the N-terminal coiled-coil region of SNAP25. Interacts with BCAR1/p130Cas and SRC through its C-terminal domain. Interacts with CSK, CTTN, SORBS3/vinexin, SYP and MAPRE3/EB3. Expressed in some primary breast carcinomas where its presence is significantly associated with increased tumor size. Not detected in normal breast tissue. Belongs to the SRCIN1 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: postsynaptic membrane; focal adhesion; axon; cytoplasm; dendrite; postsynaptic density; synapse; actin cytoskeleton

Molecular Function: protein binding; protein kinase binding

Biological Process: exocytosis; regulation of cell migration
Show more

Research Articles on SNIP

1. p140Cap immobilizes E-cadherin at the cell membrane and inhibits EGFR and Erk1/2 signalling, blocking scatter and proliferation of cancer cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SNIP antibody

 Reference Product  PubMed Publications
 BCAR1 antibody  >1 publications with SNIP and BCAR1
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