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SNRPC Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6500007

MBS6500007 is an antibody targeting SNRPC. Also known as SNRPC, CT (U1 Small Nuclear Ribonucleoprotein C, U1 snRNP Protein C, U1-C, U1C) (MaxLight 490). Reactive in Human. Host: Rabbit. More details

$1060 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SNRPC, Polyclonal Antibody
Full Product Name
SNRPC, CT (U1 Small Nuclear Ribonucleoprotein C, U1 snRNP Protein C, U1-C, U1C) (MaxLight 490)
Product Gene Name
anti-SNRPC antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.
Purity/Purification
Purified by Ammonium Sulfate Precipitation.
Specificity
Recognizes human SNRPC.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
19.8 kDa (182aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
OMIM
603522
3D Structure
ModBase 3D Structure for P09234
Immunogen
Synthetic peptide selected from the C-terminal region of human SNRPC (KLH).
Conjugate
MaxLight490
Note
Preservative Free

Product Categories/Family for anti-SNRPC antibody

Antibodies; Nuclear Proteins
Applications Tested/Suitable for anti-SNRPC antibody
Western Blot (WB), FLISA
Application Notes for anti-SNRPC antibody
WB: 1:50-1:100
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-SNRPC antibody

Western blot analysis of anti-SNRPC Antibody (C-term) in K562 cell line lysates (35ug/lane). SNRPC(arrow) was detected using the purified Pab.
Rabbit Anti-SNRPC Polyclonal Antibody – Cat# MBS6500007

Immunohistochemistry (IHC) of anti-SNRPC antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with PSMA6 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-SNRPC Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6500007

Flow Cytometry (FC/FACS) of anti-SNRPC antibody

SNRPC Antibody (C-term) flow cytometry analysis of K562 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-SNRPC Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6500007

Product References and Citations for anti-SNRPC antibody

1. Hochleitner, E.O., J. Biol. Chem. 280(4), 2536-2542 (2005). 2. Muto, Y., J. Mol. Biol. 341(1), 185-198 (2004). 3. Forch, P., EMBO J. 21(24), 6882-6892 (2002). 4. Gunnewiek, J.M., Nucleic Acids Res. 23(23), 4864-4871 (1995).

Other Notes

Small volumes of anti-SNRPC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SNRPC. It may not necessarily be applicable to this product.

NCBI GI #
4507127
NCBI GeneID
6631
NCBI Accession #
NP_003084
UniProt Primary Accession #
P09234
UniProt Secondary Accession #
Q5TAL3
UniProt Related Accession #
P09234
GenBank Nucleotide #
NM_003093.2
NCBI Official Full Name
U1 small nuclear ribonucleoprotein C
NCBI Official Synonym Full Names
small nuclear ribonucleoprotein polypeptide C
NCBI Official Symbol
SNRPC
NCBI Official Synonym Symbols
U1C; Yhc1
UniProt Protein Name
U1 small nuclear ribonucleoprotein C
UniProt Gene Name
SNRPC
UniProt Entry Name
RU1C_HUMAN
NCBI Protein Information
U1 small nuclear ribonucleoprotein C

NCBI Summary for SNRPC

This gene encodes one of the specific protein components of the U1 small nuclear ribonucleoprotein (snRNP) particle required for the formation of the spliceosome. The encoded protein participates in the processing of nuclear precursor messenger RNA splicing. snRNP particles are attacked by autoantibodies frequently produced by patients with connective tissue diseases. The genome contains several pseudogenes of this functional gene. Alternative splicing results in a non-coding transcript variant.[provided by RefSeq, Oct 2009]
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UniProt Comments for SNRPC

snRNP C: Component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Belongs to the U1 small nuclear ribonucleoprotein C family.

Protein type: RNA splicing; Spliceosome; RNA-binding

Chromosomal Location of Human Ortholog: 6p21.31

Cellular Component: nucleoplasm; Cajal body; snRNP U1

Molecular Function: mRNA binding; protein binding; single-stranded RNA binding; protein homodimerization activity; U1 snRNA binding; zinc ion binding

Biological Process: nuclear mRNA splicing, via spliceosome; nuclear mRNA 5'-splice site recognition; spliceosomal snRNP biogenesis
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Research Articles on SNRPC

1. these studies establish potentially converging disease mechanisms in amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy, with ALS-causative mutants acquiring properties representing both gain and loss of function.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SNRPC antibody

 Reference Product  PubMed Publications
 SNRPE antibody  >1 publications with SNRPC and SNRPE
 SNRPF antibody  >1 publications with SNRPC and SNRPF

Pathways associated with anti-SNRPC antibody

 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Processing Of Capped Intron-Containing Pre-mRNA Pathway antibodies  Processing Of Capped Intron-Containing Pre-mRNA Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Spliceosome, U1-snRNP Pathway antibodies  Spliceosome, U1-snRNP Pathway Diagram
 Spliceosome, U1-snRNP Pathway antibodies  Spliceosome, U1-snRNP Pathway Diagram
 MRNA Splicing Pathway antibodies  MRNA Splicing Pathway Diagram
 MRNA Splicing - Major Pathway antibodies  MRNA Splicing - Major Pathway Diagram

Diseases associated with anti-SNRPC antibody

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >2 publications with SNRPC and Immune System Diseases
 Hypertension Antibodies  >1 publications with SNRPC and Hypertension

Organs/Tissues associated with anti-SNRPC antibody

 Organ/Tissue Name  Pubmed Publications
 Thyroid Antibodies  >1 publications with SNRPC and Thyroid
 Blood Antibodies  >1 publications with SNRPC and Blood
 Connective Tissue Antibodies  >1 publications with SNRPC and Connective Tissue
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