Rabbit Anti-SNX2 Polyclonal Antibody – Cat# MBS6010727

SNX2 Antibody (C-term) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the SNX2 antibody detected the SNX2 protein (arrow).

SNX2 Antibody – Rabbit Polyclonal

Name: SNX2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6010727
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6010727

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with formin-binding protein 17, but… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SNX2, Polyclonal Antibody

Full Product Name

SNX2, CT (SNX2, Sorting nexin-2, Transformation-related gene 9 protein)

Product Gene Name

anti-SNX2 antibody

Product Synonym Names

Anti -SNX2, CT (SNX2, Sorting nexin-2, Transformation-related gene 9 protein)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

58,471 Da

Chromosome Location

Chromosome: 5; NC_000005.9 (122110691..122170234). Location: 5q23

OMIM

605929

3D Structure

ModBase 3D Structure for O60749

Immunogen

SNX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 456-485 amino acids from the C-terminal region of human SNX2.

Product Categories/Family for anti-SNX2 antibody

Antibodies; Abs to SNX (Sorting Nexin) Proteins

Applications Tested/Suitable for anti-SNX2 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-SNX2 antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-SNX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SNX2 purchase

MBS6010727 is an antibody targeting SNX2. Also known as SNX2, CT (SNX2, Sorting nexin-2, Transformation-related gene 9 protein). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SNX2. It may not necessarily be applicable to this product.

NCBI GI #

23111038

NCBI GeneID

6643

NCBI Accession #

NP_003091.2

UniProt Primary Accession #

O60749

UniProt Secondary Accession #

O43650; P82862; Q53XK8; Q597H6; Q9BTS8; B3KN44

UniProt Related Accession #

O60749

GenBank Nucleotide #

NM_003100.3

NCBI Official Full Name

sorting nexin-2 isoform 1

NCBI Official Synonym Full Names

sorting nexin 2

NCBI Official Symbol

SNX2

NCBI Official Synonym Symbols

TRG-9

UniProt Protein Name

Sorting nexin-2

UniProt Synonym Protein Names

Transformation-related gene 9 protein

Protein Family

Sorting nexin

UniProt Gene Name

SNX2

UniProt Synonym Gene Names

TRG-9

UniProt Entry Name

SNX2_HUMAN

NCBI Protein Information

sorting nexin-2; transformation-related gene 9 protein

NCBI Summary for SNX2

This gene belongs to the sorting nexin family whose members contain the phosphoinositide-binding phox (PX) domain. The encoded protein is a component of the retromer complex which plays a role in protein sorting in the endocytic pathway. This protein may form oligomeric complexes with other family members. Alternate splicing results in multiple transcript variants of this gene. Pseudogenes associated with this gene are located on chromosomes 1 and 7. [provided by RefSeq, May 2013]

UniProt Comments for SNX2

SNX2: May be involved in several stages of intracellular trafficking. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Belongs to the sorting nexin family.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 5q23

Cellular Component: extrinsic to membrane; protein complex; membrane; intracellular membrane-bound organelle; retromer complex; early endosome membrane; lamellipodium; cytoplasm; endosome membrane

Molecular Function: protein binding; insulin receptor binding; phosphoinositide binding; epidermal growth factor receptor binding

Biological Process: intracellular protein transport; vesicle organization and biogenesis; endocytosis; retrograde transport, endosome to Golgi; protein oligomerization

Research Articles on SNX2

1. Silencing of SNX2 markedly alters sensitivity to anticancer drugs targeted to c-Met.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SNX2 antibody

Reference Product	PubMed Publications
SNX1 antibody	>25 publications with SNX2 and SNX1
VPS29 antibody	>9 publications with SNX2 and VPS29
SNX4 antibody	>3 publications with SNX2 and SNX4
FNBP1 antibody	>1 publications with SNX2 and FNBP1

Pathways associated with anti-SNX2 antibody

Products by Pathway	Pathway Diagram
Clathrin Derived Vesicle Budding Pathway antibodies	Clathrin Derived Vesicle Budding Pathway Diagram
Golgi Associated Vesicle Biogenesis Pathway antibodies	Golgi Associated Vesicle Biogenesis Pathway Diagram
Membrane Trafficking Pathway antibodies	Membrane Trafficking Pathway Diagram
TGF-beta Receptor Signaling Pathway antibodies	TGF-beta Receptor Signaling Pathway Diagram
Trans-Golgi Network Vesicle Budding Pathway antibodies	Trans-Golgi Network Vesicle Budding Pathway Diagram

Diseases associated with anti-SNX2 antibody

Disease Name	Pubmed Publications
Congenital Abnormalities Antibodies	>1 publications with SNX2 and Congenital Abnormalities
Nervous System Malformations Antibodies	>1 publications with SNX2 and Nervous System Malformations

Organs/Tissues associated with anti-SNX2 antibody

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>7 publications with SNX2 and Kidney
Embryonic Tissue Antibodies	>2 publications with SNX2 and Embryonic Tissue
Brain Antibodies	>2 publications with SNX2 and Brain
Thyroid Antibodies	>1 publications with SNX2 and Thyroid
Lung Antibodies	>1 publications with SNX2 and Lung