SOCS6 Antibody – Mouse Polyclonal

The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]

SOCS6: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 18q22.2

Cellular Component: cytoplasm; immunological synapse

Molecular Function: protein binding; protein kinase inhibitor activity

Biological Process: proteasomal protein catabolic process; regulation of growth; cytokine and chemokine mediated signaling pathway; protein ubiquitination; negative regulation of protein kinase activity; defense response; JAK-STAT cascade; negative regulation of JAK-STAT cascade; negative regulation of T cell activation