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SOX8 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9447691

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming… More details

$435 / 0.1 mL (Biotin) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SOX8, Polyclonal Antibody
Full Product Name
SOX8 Conjugated Antibody
Product Gene Name
anti-SOX8 antibody
Product Synonym Names
MGC24837; SOX8; Transcription factor SOX-8
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide
Specificity
The antibody detects endogenous levels of total SOX8 protein.
Preparation and Storage
Store at 4 degree C for 6 months.
Molecular Weight
80,131 Da
Chromosome Location
Chromosome: X; NC_000023.10 (46458686..46618607, complement). Location: Xp11.3; Xp11.3
OMIM
605923
3D Structure
ModBase 3D Structure for P57073
Immunogen
Synthetic peptide corresponding to residues near the C terminal of human SRY (sex determining region Y)-box 8
Conjugation
Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
Excitation Emission
AF350: 346nm/442nm
Applications Tested/Suitable for anti-SOX8 antibody
Most Applications
Application Notes for anti-SOX8 antibody
Suggested Dilution:
AF350 conjugated: most applications: 1:50-1:250
AF405 conjugated: most applications: 1:50-1:250
AF488 conjugated: most applications: 1:50-1:250
AF555 conjugated: most applications: 1:50-1:250
AF594 conjugated: most applications: 1:50-1:250
AF647 conjugated: most applications: 1:50-1:250
AF680 conjugated: most applications: 1:50-1:250
AF750 conjugated: most applications: 1:50-1:250
Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000

Other Notes

Small volumes of anti-SOX8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SOX8 purchase

MBS9447691 is an antibody targeting SOX8. Also known as SOX8 Conjugated Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SOX8. It may not necessarily be applicable to this product.

NCBI GI #
14211919
NCBI GeneID
84679
NCBI Accession #
NP_115980.1
UniProt Primary Accession #
P57073
UniProt Secondary Accession #
O75827; Q5JXP9
UniProt Related Accession #
Q96T83
GenBank Nucleotide #
NM_032591.2
NCBI Official Full Name
sodium/hydrogen exchanger 7 isoform 2
NCBI Official Synonym Full Names
solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
NCBI Official Symbol
SLC9A7
NCBI Official Synonym Symbols
NHE7; NHE-7; SLC9A6
UniProt Protein Name
Transcription factor SOX-8
Protein Family
Transcription factor
UniProt Gene Name
SOX8
UniProt Entry Name
SOX8_HUMAN
NCBI Protein Information
sodium/hydrogen exchanger 7; Na(+)/H(+) exchanger 7; nonselective sodium potassium/proton exchanger; solute carrier family 9 (sodium/hydrogen exchanger), isoform 7

NCBI Summary for SOX8

This gene encodes a sodium and potassium/ proton antiporter that is a member of the solute carrier family 9 protein family. The encoded protein is primarily localized to the trans-Golgi network and is involved in maintaining pH homeostasis in organelles along the secretory and endocytic pathways. This protein may enhance cell growth of certain breast tumors. This gene is part of a gene cluster on chromosome Xp11.23. A pseudogene of this gene is found on chromosome 12. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
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UniProt Comments for SOX8

SOX8: May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: cytoplasm; nucleus

Molecular Function: DNA binding; protein heterodimerization activity; transcription factor binding

Biological Process: negative regulation of photoreceptor cell differentiation; transcription from RNA polymerase II promoter; fat cell differentiation; cell fate commitment; positive regulation of gliogenesis; in utero embryonic development; astrocyte fate commitment; positive regulation of transcription, DNA-dependent; male gonad development; cell maturation; signal transduction; Sertoli cell development; enteric nervous system development; peripheral nervous system development; osteoblast differentiation; retina development in camera-type eye; positive regulation of osteoblast proliferation; oligodendrocyte differentiation; spermatogenesis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of myoblast differentiation; neural crest cell migration; negative regulation of apoptosis
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Research Articles on SOX8

1. these results suggest that NHE7 enhances tumor progression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SOX8 antibody

 Reference Product  PubMed Publications
 SCAMP5 antibody  >1 publications with SOX8 and SCAMP5
 SCAMP2 antibody  >1 publications with SOX8 and SCAMP2
 SCAMP1 antibody  >1 publications with SOX8 and SCAMP1

Pathways associated with anti-SOX8 antibody

 Products by Pathway  Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Sodium/Proton Exchangers Pathway antibodies  Sodium/Proton Exchangers Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway antibodies  Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway Diagram

Diseases associated with anti-SOX8 antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >2 publications with SOX8 and Disease Models, Animal
 Inflammation Antibodies  >1 publications with SOX8 and Inflammation
 Learning Disorders Antibodies  >1 publications with SOX8 and Learning Disorders
 Neoplasms Antibodies  >1 publications with SOX8 and Neoplasms

Organs/Tissues associated with anti-SOX8 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with SOX8 and Brain
 Eye Antibodies  >2 publications with SOX8 and Eye
 Vascular Antibodies  >1 publications with SOX8 and Vascular
 Blood Antibodies  >1 publications with SOX8 and Blood
 Embryonic Tissue Antibodies  >1 publications with SOX8 and Embryonic Tissue
 Skin Antibodies  >1 publications with SOX8 and Skin
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