Rabbit Anti-SPAG1 Polyclonal Antibody – Cat# MBS3216879

WB Suggested Anti-SPAG1 Antibody
Titration: 1.0 ug/ml
Positive Control: Fetal kidney

SPAG1 Antibody – Rabbit Polyclonal

Name: SPAG1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS3216879
Price: 490 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3216879

This is a rabbit polyclonal antibody against SPAG1. It was validated on Western BlotTarget Description: The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved… More details

$490 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SPAG1, Polyclonal Antibody

Full Product Name

SPAG1 Antibody - C-terminal region

Product Gene Name

anti-SPAG1 antibody

Product Synonym Gene Name

FLJ32920; HSD-3.8; SP75; TPIS

Immunogen Sequence

Synthetic peptide located within the following region: KIEIQEVNEG KEEPGRPAGE VSMGCLASEK GGKSSRSPED PEKLPIAKPN

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human

Form/Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Purity/Purification

Affinity Purified

Preparation and Storage

For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Antibody/Peptide Pairs

SPAG1 peptide (MBS3241778) is used for blocking the activity of SPAG1 antibody (MBS3216879)

Molecular Weight

104kDa

OMIM

gene 615505

3D Structure

ModBase 3D Structure for Q07617

Homology

Human: 100%

Immunogen

The immunogen is a synthetic peptide directed towards the C-terminal region of Human SPAG1

Product Categories/Family for anti-SPAG1 antibody

Polyclonal; Membrane Protein; Signal Transduction

Applications Tested/Suitable for anti-SPAG1 antibody

Western Blot (WB)

Other Notes

Small volumes of anti-SPAG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SPAG1 purchase

MBS3216879 is an antibody targeting SPAG1. Also known as SPAG1 Antibody - C-terminal region. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SPAG1. It may not necessarily be applicable to this product.

NCBI GI #

27262636

NCBI GeneID

6674

NCBI Accession #

NP_003105

UniProt Primary Accession #

Q07617

UniProt Related Accession #

Q07617

GenBank Nucleotide #

NM_003114

NCBI Official Full Name

sperm-associated antigen 1

NCBI Official Synonym Full Names

sperm associated antigen 1

NCBI Official Symbol

SPAG1

NCBI Official Synonym Symbols

SP75; TPIS; CT140; CILD28; HSD-3.8; HEL-S-268

UniProt Protein Name

Sperm-associated antigen 1

UniProt Synonym Protein Names

HSD-3.8; Infertility-related sperm protein Spag-1

Protein Family

Sperm-associated antigen

UniProt Gene Name

SPAG1

UniProt Entry Name

SPAG1_HUMAN

NCBI Protein Information

sperm-associated antigen 1

NCBI Summary for SPAG1

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein. [provided by RefSeq, Jul 2008]

UniProt Comments for SPAG1

SPAG1: Plays a role in fertilization. Binds GTP and has GTPase activity.

Protein type: Cancer Testis Antigen (CTA); Microtubule-binding

Chromosomal Location of Human Ortholog: 8q22.2

Cellular Component: nucleoplasm; microtubule cytoskeleton; cytoplasm

Molecular Function: GTP binding; hydrolase activity

Biological Process: metabolic process; single fertilization

Disease: Ciliary Dyskinesia, Primary, 28

Research Articles on SPAG1

1. SPAG1 probably plays a role in the cytoplasmic assembly.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-SPAG1 antibody

Disease Name	Pubmed Publications
Infertility, Female Antibodies	>2 publications with SPAG1 and Infertility, Female
Congenital Abnormalities Antibodies	>1 publications with SPAG1 and Congenital Abnormalities
Lung Neoplasms Antibodies	>1 publications with SPAG1 and Lung Neoplasms
Breast Neoplasms Antibodies	>1 publications with SPAG1 and Breast Neoplasms

Organs/Tissues associated with anti-SPAG1 antibody

Organ/Tissue Name	Pubmed Publications
Testis Antibodies	>7 publications with SPAG1 and Testis
Skin Antibodies	>1 publications with SPAG1 and Skin
Embryonic Tissue Antibodies	>1 publications with SPAG1 and Embryonic Tissue
Lung Antibodies	>1 publications with SPAG1 and Lung
Kidney Antibodies	>1 publications with SPAG1 and Kidney