SS18 Antibody – Rabbit Polyclonal

SS18: Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. A chromosomal aberration involving SS18 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency). Belongs to the SS18 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oncoprotein; Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 18q11.2

Cellular Component: cytoplasmic microtubule; nucleus

Molecular Function: protein binding; ligand-dependent nuclear receptor transcription coactivator activity

Biological Process: response to drug; transcription, DNA-dependent; cell morphogenesis; ephrin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; microtubule cytoskeleton organization and biogenesis