ST3GAL2 Antibody – Rabbit Polyclonal

The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4A. [provided by RefSeq, Jul 2008]

ST3GAL2: It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found in terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values. Belongs to the glycosyltransferase 29 family.

Protein type: Glycan Metabolism - O-glycan biosynthesis; Transferase; Membrane protein, integral; Glycan Metabolism - glycosphingolipid biosynthesis - ganglio series; Glycan Metabolism - keratan sulfate biosynthesis; Glycan Metabolism - glycosphingolipid biosynthesis - globo series; EC 2.4.99.4

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: extracellular region; Golgi membrane; integral to Golgi membrane

Molecular Function: beta-galactoside alpha-2,3-sialyltransferase activity

Biological Process: amino sugar metabolic process; carbohydrate metabolic process; cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; ganglioside biosynthetic process; glycosaminoglycan metabolic process; keratan sulfate biosynthetic process; keratan sulfate metabolic process; O-glycan processing; oligosaccharide metabolic process; post-translational protein modification; protein amino acid N-linked glycosylation via asparagine; protein amino acid O-linked glycosylation; protein modification process