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STX4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6352361

Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
STX4, Polyclonal Antibody
Full Product Name
STX4, ID (STX4, STX4A, Syntaxin-4, Renal carcinoma antigen NY-REN-31) (Azide free) (HRP)
Product Gene Name
anti-STX4 antibody
Product Synonym Names
STX4; STX4A; Syntaxin-4; Renal carcinoma antigen NY-REN-31
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
Purity/Purification
Purified by Protein A and Peptide Affinity Chromatography.
Specificity
Recognizes human STX4.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
34,180 Da
Chromosome Location
Chromosome: 16; NC_000016.10 (31033095..31040168). Location: 16p11.2
OMIM
186591
3D Structure
ModBase 3D Structure for Q12846
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 132-160 in the central region of human STX4, Swiss/UniProt Accession: Q12846. Species sequence homology: bovine, mouse, rat
Conjugate
HRP
Note
Preservative Free

Product Categories/Family for anti-STX4 antibody

Antibodies; Cancer Markers
Applications Tested/Suitable for anti-STX4 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-STX4 antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-STX4 antibody

Western Blot analysis in MDA-MB231 cell line lysates (35ug/lane) usingMBS647072. This demonstrates MBS647072 detected the STX4 protein (arrow).
Rabbit Anti-STX4 Polyclonal Antibody – Cat# MBS6352361

Product References and Citations for anti-STX4 antibody

1. Evesson, F.J., et al. J. Biol. Chem. 285(37):28529-28539 (2010). 2. Kennedy, M.J., et al. Cell 141(3):524-535 (2010). 3. Brochetta, C., et al. Biochim. Biophys. Acta 1783(10):1781-1791(2008). 4. Cooper, G.M., et al. Blood 112(4):1022-1027 (2008). 5. Low, S.H., et al. Mol. Biol. Cell 17(2):977-989 (2006).

Other Notes

Small volumes of anti-STX4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for STX4 purchase

MBS6352361 is an antibody targeting STX4. Also known as STX4, ID (STX4, STX4A, Syntaxin-4, Renal carcinoma antigen NY-REN-31) (Azide free) (HRP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for STX4. It may not necessarily be applicable to this product.

NCBI GI #
20149560
NCBI GeneID
6810
NCBI Accession #
NP_004595.2
UniProt Primary Accession #
Q12846
UniProt Secondary Accession #
Q15525; Q6FHE8
UniProt Related Accession #
Q12846
GenBank Nucleotide #
NM_004604.4
NCBI Official Full Name
syntaxin-4 isoform 3
NCBI Official Synonym Full Names
syntaxin 4
NCBI Official Symbol
STX4
NCBI Official Synonym Symbols
STX4A; p35-2
UniProt Protein Name
Syntaxin-4
UniProt Synonym Protein Names
Renal carcinoma antigen NY-REN-31
Protein Family
Syntaxin-binding protein
UniProt Gene Name
STX4
UniProt Synonym Gene Names
STX4A
UniProt Entry Name
STX4_HUMAN
NCBI Protein Information
syntaxin-4; syntaxin 4A (placental); renal carcinoma antigen NY-REN-31

UniProt Comments for STX4

STX4: a protein of the syntaxin/epimorphin family. Contains 1 t-SNARE coiled-coil homology domain. Potentially involved in docking of synaptic vesicles at presynaptic active zones. Interacts with SNAP23 and SNAP25BP. Found in a complex with VAMP8 and SNAP23 in pancreas.

Protein type: Vesicle; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: extracellular space; specific granule; cell surface; lateral loop; basolateral plasma membrane; integral to membrane; dendritic spine; trans-Golgi network; cytosol; SNARE complex; synaptic vesicle; membrane; perinuclear region of cytoplasm; lamellipodium; plasma membrane; vacuole; synapse; intracellular; endosome

Molecular Function: sphingomyelin phosphodiesterase activator activity; SNAP receptor activity; SNARE binding; protein binding

Biological Process: positive regulation of catalytic activity; platelet activation; positive regulation of cell adhesion; organelle fusion; positive regulation of eosinophil degranulation; positive regulation of chemotaxis; positive regulation of immunoglobulin secretion; synaptic vesicle fusion to presynaptic membrane; regulation of exocytosis; intracellular protein transport; response to hydroperoxide; vesicle docking; positive regulation of cell proliferation; post-Golgi vesicle-mediated transport; blood coagulation; positive regulation of cell migration
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-STX4 antibody

 Reference Product  PubMed Publications
 VAMP3 antibody  >5 publications with STX4 and VAMP3
 SNAP23 antibody  >5 publications with STX4 and SNAP23
 STXBP4 antibody  >2 publications with STX4 and STXBP4
 VAMP2 antibody  >2 publications with STX4 and VAMP2
 VAMP4 antibody  >1 publications with STX4 and VAMP4
 VAMP8 antibody  >1 publications with STX4 and VAMP8
 STXBP3 antibody  >1 publications with STX4 and STXBP3

Pathways associated with anti-STX4 antibody

 Products by Pathway  Pathway Diagram
 Botulinum Neurotoxicity Pathway antibodies  Botulinum Neurotoxicity Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Disinhibition Of SNARE Formation Pathway antibodies  Disinhibition Of SNARE Formation Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Insulin-mediated Glucose Transport Pathway antibodies  Insulin-mediated Glucose Transport Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram

Organs/Tissues associated with anti-STX4 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2 publications with STX4 and Blood
 Brain Antibodies  >2 publications with STX4 and Brain
 Nerve Antibodies  >1 publications with STX4 and Nerve
 Kidney Antibodies  >1 publications with STX4 and Kidney
 Eye Antibodies  >1 publications with STX4 and Eye
 Liver Antibodies  >1 publications with STX4 and Liver
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