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STX7 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3222046

May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
STX7, Polyclonal Antibody
Full Product Name
STX7 Antibody - middle region
Product Gene Name
anti-STX7 antibody
Immunogen Sequence
Synthetic peptide located within the following region: YIKEFGSLPT TPSEQRQRKI QKDRLVAEFT TSLTNFQKVQ RQAAEREKEF
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
STX7 peptide (MBS3246753) is used for blocking the activity of STX7 antibody (MBS3222046)
Molecular Weight
26 kDa
OMIM
603217
3D Structure
ModBase 3D Structure for O15400
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of Human STX7

Product Categories/Family for anti-STX7 antibody

Polyclonal; Membrane & Traffic
Applications Tested/Suitable for anti-STX7 antibody
Western Blot (WB)

Western Blot (WB) of anti-STX7 antibody

Host: Rabbit
Target Name: STX7
Sample Tissue: Human U937 Whole Cell lysates
Antibody Dilution: 1ug/ml
Rabbit Anti-STX7 Polyclonal Antibody – Cat# MBS3222046

Other Notes

Small volumes of anti-STX7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for STX7 purchase

MBS3222046 is an antibody targeting STX7. Also known as STX7 Antibody - middle region. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for STX7. It may not necessarily be applicable to this product.

NCBI GI #
170932494
NCBI GeneID
8417
NCBI Accession #
NP_003560.2
UniProt Primary Accession #
O15400
UniProt Related Accession #
O15400
GenBank Nucleotide #
NM_003569.2
NCBI Official Full Name
syntaxin-7 isoform a
NCBI Official Synonym Full Names
syntaxin 7
NCBI Official Symbol
STX7
UniProt Protein Name
Syntaxin-7
Protein Family
Syntaxin
UniProt Gene Name
STX7
UniProt Entry Name
STX7_HUMAN
NCBI Protein Information
syntaxin-7

NCBI Summary for STX7

The protein encoded by this gene is a syntaxin family membrane receptor involved in vesicle transport. The encoded protein binds alpha-SNAP, an important regulator of transport vesicle fusion. Along with syntaxin 13, this protein plays a role in the ordered fusion of endosomes and lysosomes with the phagosome. [provided by RefSeq, May 2016]
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UniProt Comments for STX7

STX7: May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. Belongs to the syntaxin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6q23.1

Cellular Component: intracellular membrane-bound organelle; lysosomal membrane; lysosome; early endosome; integral to membrane; immunological synapse; endomembrane system; SNARE complex; azurophil granule; recycling endosome; endocytic vesicle; perinuclear region of cytoplasm; early endosome membrane; late endosome; plasma membrane; vesicle; endosome

Molecular Function: SNAP receptor activity; SNARE binding; chloride channel inhibitor activity; syntaxin binding

Biological Process: vesicle fusion; intracellular protein transport; organelle localization; vesicle docking; positive regulation of T cell mediated cytotoxicity
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Research Articles on STX7

1. Data suggest that accumulation of recycling T cell receptors at the immunological synapse is SNARE-dependent and that Stx7-mediated processing of recycling TCRs through endosomes is a prerequisite for the cytolytic function of cytotoxic T lymphocytes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-STX7 antibody

 Reference Product  PubMed Publications
 STX8 antibody  >5 publications with STX7 and STX8
 VTI1B antibody  >4 publications with STX7 and VTI1B
 STX6 antibody  >3 publications with STX7 and STX6
 VAMP8 antibody  >3 publications with STX7 and VAMP8
 VAMP3 antibody  >1 publications with STX7 and VAMP3
 VAMP7 antibody  >1 publications with STX7 and VAMP7

Pathways associated with anti-STX7 antibody

 Products by Pathway  Pathway Diagram
 Botulinum Neurotoxicity Pathway antibodies  Botulinum Neurotoxicity Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Proteolytic Cleavage Of SNARE Complex Proteins Pathway antibodies  Proteolytic Cleavage Of SNARE Complex Proteins Pathway Diagram
 SNARE Interactions In Vesicular Transport Pathway antibodies  SNARE Interactions In Vesicular Transport Pathway Diagram
 SNARE Interactions In Vesicular Transport Pathway antibodies  SNARE Interactions In Vesicular Transport Pathway Diagram

Diseases associated with anti-STX7 antibody

 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >1 publications with STX7 and Fibrosis
 Skin Neoplasms Antibodies  >1 publications with STX7 and Skin Neoplasms

Organs/Tissues associated with anti-STX7 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1 publications with STX7 and Brain
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