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SULT1A3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6352492

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and… More details

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Product Overview

Online Datasheet in PDF
Product Name
SULT1A3, Polyclonal Antibody
Full Product Name
SULT1A3, ID (SULT1A3, STM, Sulfotransferase 1A3/1A4, Aryl sulfotransferase 1A3/1A4, Catecholamine-sulfating phenol sulfotransferase, HAST3, M-PST, Monoamine-sulfating phenol sulfotransferase, Placental estrogen sulfotransferase, Sulfotransferase, monoamin
Product Gene Name
anti-SULT1A3 antibody
Product Synonym Names
SULT1A3; STM; Sulfotransferase 1A3/1A4; Aryl sulfotransferase 1A3/1A4; Catecholamine-sulfating phenol sulfotransferase; HAST3; M-PST; Monoamine-sulfating phenol sulfotransferase; Placental estrogen sulfotransferase; Sulfotransferase; monoamine-preferring; Thermolabile phenol sulfotransferase
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
3D Structure
ModBase 3D Structure for P50224
Immunogen
SULT1A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-95 amino acids from the Central region of human SULT1A3.
Conjugate
FITC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-SULT1A3 antibody

Antibodies; Enzymes; Sulfotransferase
Applications Tested/Suitable for anti-SULT1A3 antibody
Immunohistochemistry (IHC), FLISA, Western Blot (WB)
Application Notes for anti-SULT1A3 antibody
IHC: 1:10-50
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-SULT1A3 antibody

SULT1A3 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the SULT1A3 antibody detected the SULT1A3 protein (arrow).
Rabbit Anti-SULT1A3 Polyclonal Antibody – Cat# MBS6352492

Immunohistochemistry (IHC) of anti-SULT1A3 antibody

SULT1A3 Antibody (Center) (AP14760c)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SULT1A3 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-SULT1A3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6352492

Product References and Citations for anti-SULT1A3 antibody

Mitra, P., et al. Biochem. Pharmacol. 78(12):1475-1482(2009). Riches, Z., et al. Drug Metab. Dispos. 37(11):2255-2261(2009). Yasuda, S., et al. Neurosci. Res. 64(3):273-279(2009). Salman, E.D., et al. Drug Metab. Dispos. 37(4):706-709(2009). Miksits, M., et al. J. Pharm. Pharmacol. 61(2):185-191(2009).

Other Notes

Small volumes of anti-SULT1A3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SULT1A3 purchase

MBS6352492 is an antibody targeting SULT1A3. Also known as SULT1A3, ID (SULT1A3, STM, Sulfotransferase 1A3/1A4, Aryl sulfotransferase 1A3/1A4, Catecholamine-sulfating phenol sulfotransferase, HAST3, M-PST, Monoamine-sulfating phenol sulfotransferase, Placental estrogen sulfotransferase, Sulfotransferase, monoamin. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SULT1A3. It may not necessarily be applicable to this product.

NCBI GI #
10835035
NCBI GeneID
6818
NCBI Accession #
NP_003157.1
NCBI Related Accession #
NP_808220.1
UniProt Primary Accession #
P50224
UniProt Related Accession #
P0DMM9
GenBank Nucleotide #
NM_003166.3
NCBI Official Synonym Full Names
sulfotransferase family 1A member 3
NCBI Official Symbol
SULT1A3
NCBI Official Synonym Symbols
STM; HAST; HAST3; M-PST; ST1A3; ST1A4; ST1A5; TL-PST; ST1A3/ST1A4
Protein Family
Sulfotransferase
NCBI Protein Information
sulfotransferase 1A3

UniProt Comments for SULT1A3

SULT1A3: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs. Belongs to the sulfotransferase 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.8.2.1; Energy Metabolism - sulfur; Transferase

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cytosol

Molecular Function: sulfotransferase activity; aryl sulfotransferase activity

Biological Process: steroid metabolic process; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; flavonoid metabolic process; unfolded protein response; xenobiotic metabolic process; sulfation; catecholamine metabolic process; 3'-phosphoadenosine 5'-phosphosulfate metabolic process
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Research Articles on SULT1A3

1. The results obtained showed clearly the differential enzymatic characteristics of SULT1A3 allozymes in mediating the sulfation of phenylephrine and salbutamol. This information may contribute toward a better understanding of the pharmacokinetics of these two drugs in individuals with distinct SULT1A3 and/or SULT1A4 genotypes.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SULT1A3 antibody

 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Cytosolic Sulfonation Of Small Molecules Pathway antibodies  Cytosolic Sulfonation Of Small Molecules Pathway Diagram
 Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway antibodies  Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway Diagram
 Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway antibodies  Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway Diagram
 Defective GGT1 Causes Glutathionuria (GLUTH) Pathway antibodies  Defective GGT1 Causes Glutathionuria (GLUTH) Pathway Diagram
 Defective GSS Causes Glutathione Synthetase Deficiency (GSS Deficiency) Pathway antibodies  Defective GSS Causes Glutathione Synthetase Deficiency (GSS Deficiency) Pathway Diagram
 Defective MAT1A Causes Methionine Adenosyltransferase Deficiency (MATD) Pathway antibodies  Defective MAT1A Causes Methionine Adenosyltransferase Deficiency (MATD) Pathway Diagram
 Defective OPLAH Causes 5-oxoprolinase Deficiency (OPLAHD) Pathway antibodies  Defective OPLAH Causes 5-oxoprolinase Deficiency (OPLAHD) Pathway Diagram
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