SYNE2 Antibody – Rabbit Polyclonal

The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

SYNE2: a nuclear transmembrane protein involved in the maintenance of nuclear organization and structural integrity. The largest part of the protein is cytoplasmic, while its C-terminal part is associated with the nuclear envelope, most probably the outer nuclear membrane. Remains associated with the nuclear envelope during its breakdown in mitotic cells. Probable anchoring protein which theters the nucleus to the cytoskeleton. Connects nuclei to the cytoskeleton by interacting with the nuclear envelope and with F-actin in the cytoplasm. Nine alternatively spliced isoforms have been described.

Protein type: Membrane protein, integral; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 14q23.2

Cellular Component: cytoplasm; filopodium membrane; focal adhesion; integral to membrane; intermediate filament cytoskeleton; mitochondrion; nuclear envelope; nuclear lumen; nuclear membrane; nuclear outer membrane; nucleoplasm; nucleus; sarcoplasmic reticulum; sarcoplasmic reticulum membrane; Z disc

Molecular Function: actin binding; actin filament binding; protein binding

Biological Process: centrosome localization; establishment and/or maintenance of cell polarity; nuclear membrane organization and biogenesis; nuclear migration; nuclear migration along microfilament; positive regulation of cell migration

Disease: Emery-dreifuss Muscular Dystrophy 5, Autosomal Dominant