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SYTL2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6353093

MBS6353093 is an antibody targeting SYTL2. Also known as SYTL2, ID (SYTL2, KIAA1597, SGA72M, SLP2, SLP2A, Synaptotagmin-like protein 2, Breast cancer-associated antigen SGA-72M, Exophilin-4) (PE). Reactive in Human. Host: Rabbit. More details

$1120 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SYTL2, Polyclonal Antibody
Full Product Name
SYTL2, ID (SYTL2, KIAA1597, SGA72M, SLP2, SLP2A, Synaptotagmin-like protein 2, Breast cancer-associated antigen SGA-72M, Exophilin-4) (PE)
Product Gene Name
Product Synonym Names
SYTL2; KIAA1597; SGA72M; SLP2; SLP2A; Synaptotagmin-like protein 2; Breast cancer-associated antigen SGA-72M; Exophilin-4
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Protein A and Peptide Affinity Chromatography.
Specificity
Recognizes human SYTL2.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
84,651 Da
OMIM
EU035829 mRNA
3D Structure
ModBase 3D Structure for Q9HCH5
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 840-868 in the central region of human SYTL2, Swiss/UniProt Accession: Q9HCH5.
Conjugate
PE
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-SYTL2 antibody

Applications Tested/Suitable for anti-SYTL2 antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB), Flow Cytometry (FC/FACS), FLISA
Application Notes for anti-SYTL2 antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-SYTL2 antibody

Western Blot analysis of Hela cell line lysates (35ug/lane)usingMBS646694. SYTL2 (arrow) was detected usingMBS646694.
Rabbit Anti-SYTL2 Polyclonal Antibody – Cat# MBS6353093

Immunohistochemistry (IHC) of anti-SYTL2 antibody

Immunohistochemistry analysis of formalin fixed and paraffin embedded brain tissue using MBS646694 followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of MBS646694 for immunohistochemistry.
Rabbit Anti-SYTL2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6353093

Flow Cytometry (FC/FACS) of anti-SYTL2 antibody

Flow Cytometric analysis of Hela cells using MBS646694 (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-SYTL2 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6353093

Product References and Citations for anti-SYTL2 antibody

1. Menasche, G., et al. Blood 112(13):5052-5062(2008). 2. Kesari, A., et al. Am. J. Pathol. 173(5):1476-1487(2008). 3. Chavas, L.M., et al. Structure 16(10):1468-1477(2008).

Other Notes

Small volumes of anti-SYTL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SYTL2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
synaptotagmin-like protein 2 isoform g
NCBI Official Synonym Full Names
synaptotagmin like 2
NCBI Official Symbol
SYTL2
NCBI Official Synonym Symbols
EXO4; SLP2; SLP2A; SGA72M; CHR11SYT; PPP1R151
UniProt Protein Name
Synaptotagmin-like protein 2
UniProt Synonym Protein Names
Breast cancer-associated antigen SGA-72M; Exophilin-4
UniProt Gene Name
SYTL2
UniProt Synonym Gene Names
KIAA1597; SGA72M; SLP2; SLP2A
NCBI Protein Information
synaptotagmin-like protein 2

NCBI Summary for SYTL2

The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A). This protein plays a role in RAB27A-dependent vesicle trafficking and controls melanosome distribution in the cell periphery. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jun 2009]
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UniProt Comments for SYTL2

Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca2+ while binding to PIP2 is Ca2+ insensitive.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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