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TAL1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6353517

TAL1 is implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation and serves as a positive regulator of erythroid differentiation. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TAL1, Polyclonal Antibody
Full Product Name
TAL1, Phosphorylated (pT90) (TAL1, BHLHA17, SCL, TCL5, T-cell acute lymphocytic leukemia protein 1, Class A basic helix-loop-helix protein 17, Stem cell protein, T-cell leukemia/lymphoma protein 5) (MaxLight 405)
Product Gene Name
anti-TAL1 antibody
Product Synonym Names
TAL1; BHLHA17; SCL; TCL5; T-cell acute lymphocytic leukemia protein 1; Class A basic helix-loop-helix protein 17; Stem cell protein; T-cell leukemia/lymphoma protein 5
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight405.
Purity/Purification
Purified by Protein A and Peptide Affinity Chromatography.
Specificity
Recognizes human TAL1.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight405 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
34,271 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (47681963..47695443, complement). Location: 1p32
OMIM
187040
3D Structure
ModBase 3D Structure for P17542
Immunogen
KLH-conjugated synthetic phosphopeptide mapping to a fragment of residues within amino acids surrounding pT90 of human TAL1, UniProt Accession #P17542.
Conjugate
MaxLight405
Antigen Modification
Phosphorylated
Note
Preservative Free

Product Categories/Family for anti-TAL1 antibody

Antibodies; Cancer Markers; Leukemia
Applications Tested/Suitable for anti-TAL1 antibody
Dot Blot (DB), FLISA
Application Notes for anti-TAL1 antibody
Applications are based on unconjugated antibody.

Dot Blot (DB) of anti-TAL1 antibody

Dot Blot analysis on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed using MBS6002077 at 0.5ug per ml.
Rabbit Anti-TAL1 Polyclonal Antibody – Cat# MBS6353517

Product References and Citations for anti-TAL1 antibody

Kassouf, M.T., Blood 112 (4), 1056-1067 (2008). Terme, J.M., J. Virol. 82 (16), 7913-7922 (2008). Brunet de la Grange, P., Stem Cells 26 (6), 1658-1662 (2008).

Other Notes

Small volumes of anti-TAL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TAL1 purchase

MBS6353517 is an antibody targeting TAL1. Also known as TAL1, Phosphorylated (pT90) (TAL1, BHLHA17, SCL, TCL5, T-cell acute lymphocytic leukemia protein 1, Class A basic helix-loop-helix protein 17, Stem cell protein, T-cell leukemia/lymphoma protein 5) (MaxLight 405). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TAL1. It may not necessarily be applicable to this product.

NCBI GI #
4507363
NCBI GeneID
6886
NCBI Accession #
NP_003180.1
UniProt Primary Accession #
P17542
UniProt Secondary Accession #
D3DQ24
UniProt Related Accession #
P17542
GenBank Nucleotide #
NM_003189.2
NCBI Official Full Name
T-cell acute lymphocytic leukemia protein 1
NCBI Official Synonym Full Names
T-cell acute lymphocytic leukemia 1
NCBI Official Symbol
TAL1
NCBI Official Synonym Symbols
SCL; TCL5; tal-1; bHLHa17
UniProt Protein Name
T-cell acute lymphocytic leukemia protein 1
UniProt Synonym Protein Names
Class A basic helix-loop-helix protein 17; bHLHa17; Stem cell protein; T-cell leukemia/lymphoma protein 5
Protein Family
Probable transaldolase
UniProt Gene Name
TAL1
UniProt Synonym Gene Names
BHLHA17; SCL; TCL5; TAL-1; bHLHa17
UniProt Entry Name
TAL1_HUMAN
NCBI Protein Information
T-cell acute lymphocytic leukemia protein 1; tal-1 product; stem cell protein; T-cell leukemia/lymphoma protein 5; class A basic helix-loop-helix protein 17

UniProt Comments for TAL1

TAL1: a basic helix-loop-helix transcription. Regulates differentiation and survival during hemopoiesis. Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of eryhtroid differentiation. Mutations are associated with T-cell leukemia and melanoma. Binds to the LIM domain containing protein Rhombotin-2.

Protein type: DNA-binding; Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: 1p32

Cellular Component: transcription factor complex; histone deacetylase complex; nuclear chromatin; nucleus

Molecular Function: protein binding; enzyme binding; protein heterodimerization activity; histone deacetylase binding; chromatin binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; erythrocyte maturation; cell fate commitment; positive regulation of chromatin assembly or disassembly; embryonic hemopoiesis; megakaryocyte differentiation; positive regulation of transcription, DNA-dependent; positive regulation of erythrocyte differentiation; astrocyte fate commitment; locomotory behavior; negative regulation of transcription from RNA polymerase II promoter; positive regulation of mitotic cell cycle; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; positive regulation of protein complex assembly; positive regulation of cell division; erythrocyte differentiation; spinal cord association neuron differentiation; hemopoiesis; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; platelet formation; basophil differentiation

Disease: Leukemia, Acute Lymphoblastic
Show more

Research Articles on TAL1

1. Transcriptional regulators cooperate to establish or maintain primitive stem cell-like signatures in leukemic cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TAL1 antibody

 Reference Product  PubMed Publications
 LMO2 antibody  >104 publications with TAL1 and LMO2
 LMO1 antibody  >25 publications with TAL1 and LMO1
 TCF3 antibody  >16 publications with TAL1 and TCF3
 GATA3 antibody  >15 publications with TAL1 and GATA3
 SP1 antibody  >9 publications with TAL1 and SP1
 EP300 antibody  >4 publications with TAL1 and EP300
 MAPK3 antibody  >3 publications with TAL1 and MAPK3
 HDAC1 antibody  >3 publications with TAL1 and HDAC1
 SIN3A antibody  >2 publications with TAL1 and SIN3A

Diseases associated with anti-TAL1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >271 publications with TAL1 and Neoplasms
 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Antibodies  >65 publications with TAL1 and Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
 Anemia Antibodies  >15 publications with TAL1 and Anemia
 Disease Models, Animal Antibodies  >14 publications with TAL1 and Disease Models, Animal
 Liver Diseases Antibodies  >2 publications with TAL1 and Liver Diseases
 Vascular Diseases Antibodies  >2 publications with TAL1 and Vascular Diseases
 Pain Antibodies  >1 publications with TAL1 and Pain
 Skin Neoplasms Antibodies  >1 publications with TAL1 and Skin Neoplasms
 Necrosis Antibodies  >1 publications with TAL1 and Necrosis
 Hypertrophy Antibodies  >1 publications with TAL1 and Hypertrophy

Organs/Tissues associated with anti-TAL1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >274 publications with TAL1 and Blood
 Bone Marrow Antibodies  >81 publications with TAL1 and Bone Marrow
 Liver Antibodies  >40 publications with TAL1 and Liver
 Brain Antibodies  >19 publications with TAL1 and Brain
 Spleen Antibodies  >15 publications with TAL1 and Spleen
 Heart Antibodies  >12 publications with TAL1 and Heart
 Lung Antibodies  >4 publications with TAL1 and Lung
 Placenta Antibodies  >2 publications with TAL1 and Placenta
 Eye Antibodies  >1 publications with TAL1 and Eye
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