• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

TARBP2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6396031

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA… More details

$1165 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TARBP2, Polyclonal Antibody
Full Product Name
TARBP2 (TRBP, RISC-loading Complex Subunit TARBP2, TAR RNA-binding Protein 2, Trans-activation-responsive RNA-binding Protein) (HRP)
Product Gene Name
anti-TARBP2 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human TARBP2.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
OMIM
605053
3D Structure
ModBase 3D Structure for Q15633
Immunogen
Full length human TARBP2, aa1-366 (NP_599150.1).
Immunogen Sequence
MSEEEQGSGTTTGCGLPSIEQMLAANPGKTPISLLQEYGTRIGKTPVYDLLKAEGQAHQPNFTFRVTVGDTSCTGQGPSKKAAKHKAAEVALKHLKGGSMLEPALEDSSSFSPLDSSLPEDIPVFTAAAAATPVPSVVLTRSPPMELQPPVSPQQSECNPVGALQELVVQKGWRLPEYTVTQESGPAHRKEFTMTCRVERFIEIGSGTSKKLAKRNAAAKMLLRVHTVPLDARDGNEVEPDDDHFSIGVGSRLDGLRNRGPGCTWDSLRNSVGEKILSLRSCSLGSLGALGPACCRVLSELSEEQAFHVSYLDIEELSLSGLCQCLVELSTQPATVCHGSATTREAARGEAARRALQYLKIMAGSK
Conjugate
HRP
Note
Preservative Free

Product Categories/Family for anti-TARBP2 antibody

Antibodies; RNA Binding Proteins
Applications Tested/Suitable for anti-TARBP2 antibody
Western Blot (WB)
Application Notes for anti-TARBP2 antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-TARBP2 antibody

TARBP2 rabbit polyclonal antibody. Western Blot analysis of TARBP2 expression in human kidney.
Rabbit Anti-TARBP2 Polyclonal Antibody – Cat# MBS6396031

Western Blot (WB) of anti-TARBP2 antibody

Western Blot analysis of TARBP2 expression in transfected 293T cell line by TARBP2 polyclonal antibody. Lane 1: TARBP2 transfected lysate (39kD). Lane 2: Non-transfected lysate.
Rabbit Anti-TARBP2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6396031

Other Notes

Small volumes of anti-TARBP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TARBP2 purchase

MBS6396031 is an antibody targeting TARBP2. Also known as TARBP2 (TRBP, RISC-loading Complex Subunit TARBP2, TAR RNA-binding Protein 2, Trans-activation-responsive RNA-binding Protein) (HRP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TARBP2. It may not necessarily be applicable to this product.

NCBI GI #
19743840
NCBI GeneID
6895
NCBI Accession #
NP_599150.1
UniProt Primary Accession #
Q15633
UniProt Related Accession #
Q15633
GenBank Nucleotide #
NM_134323.1
NCBI Official Full Name
RISC-loading complex subunit TARBP2 isoform a
NCBI Official Synonym Full Names
TARBP2 subunit of RISC loading complex
NCBI Official Symbol
TARBP2
NCBI Official Synonym Symbols
LOQS; TRBP; TRBP1; TRBP2
UniProt Protein Name
RISC-loading complex subunit TARBP2
UniProt Synonym Protein Names
TAR RNA-binding protein 2; Trans-activation-responsive RNA-binding protein
Protein Family
RISC-loading complex
UniProt Gene Name
TARBP2
UniProt Entry Name
TRBP2_HUMAN
NCBI Protein Information
RISC-loading complex subunit TARBP2

UniProt Comments for TARBP2

TRBP: the HIV-1 TAR RNA binding protein (TRBP) is a double strand RNA binding protein (dsRBP) that is required for the recruitment of Ago2 to the small interfering RNA (siRNA) bound by Dicer. TRBP increases HIV-1 expression and replication by inhibiting the interferon-induced protein kinase PKR and by increasing translation of viral mRNA. Dicer, Ago2, and TRBP are the main components of the RNA-induced silencing complex (RISC).

Protein type: Translation; Motility/polarity/chemotaxis; RNA processing; RNA-binding

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: nucleoplasm; perinuclear region of cytoplasm; cytoplasm; nucleus; cytosol

Molecular Function: protein binding; siRNA binding; protein homodimerization activity; miRNA binding; double-stranded RNA binding

Biological Process: regulation of transcription from RNA polymerase II promoter; regulation of translation; positive regulation of viral genome replication; regulation of transcription, DNA-dependent; pre-microRNA processing; regulation of viral transcription; RNA interference, targeting of mRNA for destruction; miRNA-mediated gene silencing, miRNA loading onto RISC; negative regulation of protein kinase activity; gene expression; negative regulation of defense response to virus by host; RNA interference, production of siRNA
Show more

Research Articles on TARBP2

1. Our findings may shed light on the mechanism of apoptosis, induced by the TRBP-bound miRNAs through the interaction of TRBP with LGP2, as an antiviral defense system in mammalian cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000