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TAT Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9401969

This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a… More details

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Product Overview

Online Datasheet in PDF
Product Name
TAT, Polyclonal Antibody
Full Product Name
TAT antibody
Product Gene Name
anti-TAT antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Antibodies were purified by affinity purification using immunogen.
Concentration
1.0 mg/ml (lot specific)
Specificity
The antibody detects endogenous level of total TAT antibody.
Preparation and Storage
Store at -20 degree C
Molecular Weight
50,399 Da
OMIM
276600
3D Structure
ModBase 3D Structure for P17735
Immunogen Type
Recombinant Protein
Immunogen Description
Recombinant protein of human TAT.
Target Name
TAT

Product Categories/Family for anti-TAT antibody

Total protein Ab
Applications Tested/Suitable for anti-TAT antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-TAT antibody
Western blotting: 1:500 - 1:2000
Immunofluorescence: 1:50 - 1:200

Western Blot (WB) of anti-TAT antibody

Western blot analysis of extracts of various cell lines, using TAT antibody.
Rabbit Anti-TAT Polyclonal Antibody – Cat# MBS9401969

Immunofluorescence (IF) of anti-TAT antibody

Immunofluorescence analysis of MCF7 cell using TAT antibody. Blue: DAPI for nuclear staining.
Rabbit Anti-TAT Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS9401969

Other Notes

Small volumes of anti-TAT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TAT purchase

MBS9401969 is an antibody targeting TAT. Also known as TAT antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TAT. It may not necessarily be applicable to this product.

NCBI GI #
4507369
NCBI GeneID
6898
NCBI Accession #
NP_000344.1
UniProt Primary Accession #
P17735
UniProt Secondary Accession #
B2R8I1; D3DWS2
UniProt Related Accession #
P17735
GenBank Nucleotide #
NM_000353.2
NCBI Official Full Name
tyrosine aminotransferase
NCBI Official Synonym Full Names
tyrosine aminotransferase
NCBI Official Symbol
TAT
UniProt Protein Name
Tyrosine aminotransferase
UniProt Synonym Protein Names
L-tyrosine:2-oxoglutarate aminotransferase
Protein Family
Protein
UniProt Gene Name
TAT
UniProt Synonym Gene Names
TAT
UniProt Entry Name
ATTY_HUMAN
NCBI Protein Information
tyrosine aminotransferase

UniProt Comments for TAT

TAT: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine. Defects in TAT are the cause of tyrosinemia type 2 (TYRO2); also known as Richner-Hanhart syndrome. TYRO2 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis, painful corneal ulcers, and mental retardation. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Protein type: Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - cysteine and methionine; Cofactor and Vitamin Metabolism - ubiquinone and other terpenoid-quinone biosynthesis; Mitochondrial; Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; EC 2.6.1.5; Transferase

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: mitochondrion; cytosol

Molecular Function: amino acid binding; tyrosine transaminase activity; pyridoxal phosphate binding

Biological Process: response to mercury ion; L-phenylalanine catabolic process; glutamate metabolic process; tyrosine catabolic process; response to glucocorticoid stimulus; biosynthetic process; response to oxidative stress; 2-oxoglutarate metabolic process

Disease: Tyrosinemia, Type Ii
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Research Articles on TAT

1. Two known mutations and one novel mutation was found in the TAT gene of Tunesian Richner-Hanhart syndrome patients. The geographical distribution of RHS mutations shows regional specificities.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TAT antibody

 Reference Product  PubMed Publications
 TYR antibody  >98 publications with TAT and TYR
 PAH antibody  >33 publications with TAT and PAH
 DDC antibody  >10 publications with TAT and DDC
 FOXA2 antibody  >8 publications with TAT and FOXA2
 FOXA3 antibody  >3 publications with TAT and FOXA3
 GOT2 antibody  >2 publications with TAT and GOT2
 HPD antibody  >1 publications with TAT and HPD

Pathways associated with anti-TAT antibody

 Products by Pathway  Pathway Diagram
 4-hydroxybenzoate Biosynthesis Pathway antibodies  4-hydroxybenzoate Biosynthesis Pathway Diagram
 4-hydroxybenzoate Biosynthesis I (eukaryotes) Pathway antibodies  4-hydroxybenzoate Biosynthesis I (eukaryotes) Pathway Diagram
 4-hydroxyphenylpyruvate Biosynthesis Pathway antibodies  4-hydroxyphenylpyruvate Biosynthesis Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Antibiotics Pathway antibodies  Biosynthesis Of Antibiotics Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 L-tyrosine Degradation I Pathway antibodies  L-tyrosine Degradation I Pathway Diagram

Diseases associated with anti-TAT antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >1014 publications with TAT and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >689 publications with TAT and Nervous System Diseases
 Brain Diseases Antibodies  >562 publications with TAT and Brain Diseases
 Inflammation Antibodies  >516 publications with TAT and Inflammation
 Necrosis Antibodies  >413 publications with TAT and Necrosis
 Heart Diseases Antibodies  >361 publications with TAT and Heart Diseases
 Liver Diseases Antibodies  >249 publications with TAT and Liver Diseases
 Neoplasms, Experimental Antibodies  >186 publications with TAT and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >180 publications with TAT and Liver Neoplasms
 Kidney Diseases Antibodies  >144 publications with TAT and Kidney Diseases

Organs/Tissues associated with anti-TAT antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >692 publications with TAT and Liver
 Muscle Antibodies  >305 publications with TAT and Muscle
 Mammary Gland Antibodies  >4 publications with TAT and Mammary Gland
 Uncharacterized Tissue Antibodies  >2 publications with TAT and Uncharacterized Tissue
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