tau Antibody – Rabbit Polyclonal

Phosphorylation site-specific antibody selective for the phosphorylated form of human tau containing a phosphate on serine 422. Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of tau is to promote tubulin polymerization and stabilize microtubules, but it also serves to link certain signaling pathways to the cytoskeleton. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions seen in Alzheimer's disease (AD). Hyperphosphorylation impairs the microtubule binding function of tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to degeneration of the affected neurons. Hyperphosphorylated tau is also found in a range of other central nervous system disorders. Numerous serine/threonine kinases, including GSK-3b, PKA, CDK5, MARK, MAPKs, and casein kinase II can phosphorylate tau. Serine 422 can be phosphorylated by members of the MAP kinase (MAPK) family.

Small volumes of anti-tau antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS631404 is an antibody targeting tau. Also known as Tau, phosphorylated (Ser422) (Tau Protein, Microtubule-associated Protein, MAP). Reactive in Human. Host: Rabbit.