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TECPR1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6502250

MBS6502250 is an antibody targeting TECPR1. Also known as TECPR1, CT (Tectonin beta-propeller Repeat-containing Protein 1, KIAA1358) (AP). Reactive in Human. Host: Rabbit. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TECPR1, Polyclonal Antibody
Full Product Name
TECPR1, CT (Tectonin beta-propeller Repeat-containing Protein 1, KIAA1358) (AP)
Product Gene Name
anti-TECPR1 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase.
Purity/Purification
Purified by Ammonium Sulfate Precipitation.
Specificity
Recognizes human TECPR1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
129,696 Da
Chromosome Location
Chromosome: 7; NC_000007.13 (97846036..97881468, complement). Location: 7q21.3
3D Structure
ModBase 3D Structure for Q7Z6L1
Immunogen
Synthetic peptide selected from the C-terminal region of human TECPR1 (KLH).
Conjugate
AP
Note
Preservative Free

Product Categories/Family for anti-TECPR1 antibody

Antibodies; Proteins
Applications Tested/Suitable for anti-TECPR1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-TECPR1 antibody
WB: 1:50-1:100
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-TECPR1 antibody

Western blot analysis of TECPR1 Antibody (C-term) in mouse brain tissue lysates (35ug/lane). TECPR1 (arrow) was detected using the purified Pab.
Rabbit Anti-TECPR1 Polyclonal Antibody – Cat# MBS6502250

Immunohistochemistry (IHC) of anti-TECPR1 antibody

Formalin-fixed and paraffin-embedded human brain reacted with TECPR1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-TECPR1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6502250

Flow Cytometry (FC/FACS) of anti-TECPR1 antibody

TECPR1 Antibody (C-term) flow cytometric analysis of Hela cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-TECPR1 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6502250

Other Notes

Small volumes of anti-TECPR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TECPR1. It may not necessarily be applicable to this product.

NCBI GI #
32698704
NCBI GeneID
25851
NCBI Accession #
NP_056210.1
UniProt Primary Accession #
Q7Z6L1
UniProt Secondary Accession #
Q96EB0; Q9P2I9; Q9UFR6; A8KAD1
UniProt Related Accession #
Q7Z6L1
GenBank Nucleotide #
NM_015395.1
NCBI Official Full Name
tectonin beta-propeller repeat-containing protein 1
NCBI Official Synonym Full Names
tectonin beta-propeller repeat containing 1
NCBI Official Symbol
TECPR1
NCBI Official Synonym Symbols
FLJ23419; FLJ90593; DKFZP434B0335
UniProt Protein Name
Tectonin beta-propeller repeat-containing protein 1
Protein Family
Tectonin beta-propeller repeat-containing protein
UniProt Gene Name
TECPR1
UniProt Synonym Gene Names
KIAA1358
UniProt Entry Name
TCPR1_HUMAN
NCBI Protein Information
tectonin beta-propeller repeat-containing protein 1; OTTHUMP00000205440

NCBI Summary for TECPR1

This gene encodes a tethering factor involved in autophagy. The encoded protein is found at autolysosomes, and is involved in targeting protein aggregates, damaged mitochondria, and bacterial pathogens for autophagy [provided by RefSeq, Nov 2012]

UniProt Comments for TECPR1

TECPR1: Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation. Interacts with ATG5; the interaction is direct. Interacts with WIPI2. Interacts with the ATG5-ATG12 conjugate, the interaction is however mutually exclusive with ATG16, since it does not interact with ATG12-ATG5-ATG16 complex. Belongs to the TECPR1 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system; Autophagy

Chromosomal Location of Human Ortholog: 7q21.3

Cellular Component: lysosomal membrane; integral to membrane; cytoplasmic vesicle

Molecular Function: protein binding; phosphatidylinositol 3-phosphate binding

Biological Process: autophagic vacuole fusion; autophagy
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TECPR1 antibody

 Reference Product  PubMed Publications
 ATG5 antibody  >4 publications with TECPR1 and ATG5
 ATG12 antibody  >3 publications with TECPR1 and ATG12
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