Rabbit Anti-TFB2M Polyclonal Antibody – Cat# MBS7051204

Immunohistochemistry of paraffin-embedded human pancreatic cancer using MBS7051204 at dilution of 1:100

TFB2M Antibody – Rabbit Polyclonal

Name: TFB2M Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS7051204
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS7051204

S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates… More details

$230 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TFB2M, Polyclonal Antibody

Full Product Name

TFB2M Antibody

Product Gene Name

anti-TFB2M antibody

Product Synonym Names

Dimethyladenosine transferase 2; mitochondrial; Hepatitis C virus NS5A-transactivated protein 5; HCV NS5A-transactivated protein 5; Mitochondrial 12S rRNA dimethylase 2; Mitochondrial transcription factor B2; h-mtTFB; h-mtTFB2; hTFB2M; mtTFB2; S-adenosylmethionine-6-N'; N'-adenosyl(rRNA) dimethyltransferase 2; TFB2M; NS5ATP5

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Liquid

Purity/Purification

>95%, Protein G purified

Preparation and Storage

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Matching Pairs

Unconjugated Antibody: TFB2M (MBS7051204)
HRP Conjugated Antibody: TFB2M (MBS7051205)

Matching Pairs

Unconjugated Antibody: TFB2M (MBS7051204)
FITC Conjugated Antibody: TFB2M (MBS7051206)

Molecular Weight

45,349 Da

OMIM

AF529366 mRNA

3D Structure

ModBase 3D Structure for Q9H5Q4

Immunogen

Recombinant Human Dimethyladenosine transferase 2, mitochondrial protein (30-108AA)

Preservative

0.03% Proclin 300

Constituents

50% Glycerol, 0.01M PBS, pH 7.4

Conjugation

Non-conjugated

Santa Cruz Alternative

Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-134078 / sc-160856

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-TFB2M antibody

ELISA (EIA), Immunohistochemistry (IHC)

Application Notes for anti-TFB2M antibody

IHC: 1: 20-1: 200

Other Notes

Small volumes of anti-TFB2M antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TFB2M purchase

MBS7051204 is an antibody targeting TFB2M. Also known as TFB2M Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TFB2M. It may not necessarily be applicable to this product.

NCBI GI #

11641289

NCBI GeneID

64216

NCBI Accession #

NP_071761.1

UniProt Primary Accession #

Q9H5Q4

UniProt Secondary Accession #

Q9H626

UniProt Related Accession #

Q9H5Q4

GenBank Nucleotide #

NM_022366.2

NCBI Official Full Name

dimethyladenosine transferase 2, mitochondrial

NCBI Official Synonym Full Names

transcription factor B2, mitochondrial

NCBI Official Symbol

TFB2M

NCBI Official Synonym Symbols

Hkp1; mtTFB2

UniProt Protein Name

Dimethyladenosine transferase 2, mitochondrial

UniProt Synonym Protein Names

Hepatitis C virus NS5A-transactivated protein 5; HCV NS5A-transactivated protein 5; Mitochondrial 12S rRNA dimethylase 2; Mitochondrial transcription factor B2; h-mtTFB; h-mtTFB2; hTFB2M; mtTFB2; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2

Protein Family

Dimethyladenosine transferase

UniProt Gene Name

TFB2M

UniProt Synonym Gene Names

NS5ATP5; HCV NS5A-transactivated protein 5; h-mtTFB; h-mtTFB2; hTFB2M; mtTFB2

UniProt Entry Name

TFB2M_HUMAN

NCBI Protein Information

dimethyladenosine transferase 2, mitochondrial

UniProt Comments for TFB2M

TFB2M: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity. Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.

Protein type: EC 2.1.1.-; Methyltransferase; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 1q44

Cellular Component: cell junction; mitochondrial matrix; mitochondrion

Molecular Function: rRNA (adenine-N6,N6-)-dimethyltransferase activity; transcription cofactor activity

Biological Process: mitochondrion organization and biogenesis; positive regulation of transcription, DNA-dependent; transcription from mitochondrial promoter; transcription initiation from mitochondrial promoter

Research Articles on TFB2M

1. The results reveal the organization of TFAM, POLRMT and TFB2M around the light-strand promoter and represent the first structural characterization of the entire mitochondrial transcriptional initiation complex.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TFB2M antibody

Reference Product	PubMed Publications
TFAM antibody	>48 publications with TFB2M and TFAM
POLRMT antibody	>20 publications with TFB2M and POLRMT
PPARGC1A antibody	>5 publications with TFB2M and PPARGC1A
NRF1 antibody	>5 publications with TFB2M and NRF1
GABPA antibody	>1 publications with TFB2M and GABPA

Pathways associated with anti-TFB2M antibody

Products by Pathway	Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Mitochondrial Gene Expression Pathway antibodies	Mitochondrial Gene Expression Pathway Diagram
Mitochondrial Biogenesis Pathway antibodies	Mitochondrial Biogenesis Pathway Diagram
Mitochondrial Transcription Initiation Pathway antibodies	Mitochondrial Transcription Initiation Pathway Diagram
Organelle Biogenesis And Maintenance Pathway antibodies	Organelle Biogenesis And Maintenance Pathway Diagram
RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway antibodies	RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway Diagram
Transcription From Mitochondrial Promoters Pathway antibodies	Transcription From Mitochondrial Promoters Pathway Diagram
Transcriptional Activation Of Mitochondrial Biogenesis Pathway antibodies	Transcriptional Activation Of Mitochondrial Biogenesis Pathway Diagram

Diseases associated with anti-TFB2M antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>4 publications with TFB2M and Nervous System Diseases
Cardiovascular Diseases Antibodies	>4 publications with TFB2M and Cardiovascular Diseases
Heart Diseases Antibodies	>3 publications with TFB2M and Heart Diseases
Hypertrophy Antibodies	>2 publications with TFB2M and Hypertrophy
Myocardial Infarction Antibodies	>1 publications with TFB2M and Myocardial Infarction
Fatty Liver Antibodies	>1 publications with TFB2M and Fatty Liver
Inflammation Antibodies	>1 publications with TFB2M and Inflammation
Liver Diseases Antibodies	>1 publications with TFB2M and Liver Diseases

Organs/Tissues associated with anti-TFB2M antibody

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>12 publications with TFB2M and Muscle
Blood Antibodies	>5 publications with TFB2M and Blood
Brain Antibodies	>4 publications with TFB2M and Brain
Heart Antibodies	>3 publications with TFB2M and Heart
Liver Antibodies	>2 publications with TFB2M and Liver
Mammary Gland Antibodies	>1 publications with TFB2M and Mammary Gland
Uterus Antibodies	>1 publications with TFB2M and Uterus
Embryonic Tissue Antibodies	>1 publications with TFB2M and Embryonic Tissue
Eye Antibodies	>1 publications with TFB2M and Eye
Spleen Antibodies	>1 publications with TFB2M and Spleen