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TGFBRAP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6355226

TGFBRAP1 plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the… More details

$1025 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TGFBRAP1, Polyclonal Antibody
Full Product Name
TGFBRAP1, CT (TGFBRAP1, Transforming growth factor-beta receptor-associated protein 1) (MaxLight 750)
Product Gene Name
Product Synonym Names
TGFBRAP1; Transforming growth factor-beta receptor-associated protein 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
OMIM
606237
3D Structure
ModBase 3D Structure for Q8WUH2
Immunogen
TGFBRAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 498-528 amino acids from the C-terminal region of human TGFBRAP1.
Conjugate
MaxLight750
Note
Preservative Free
Applications Tested/Suitable for anti-TGFBRAP1 antibody
Immunohistochemistry (IHC), FLISA, Western Blot (WB)
Application Notes for anti-TGFBRAP1 antibody
IHC: 1:10-50
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Product References and Citations for anti-TGFBRAP1 antibody

Rose, J. Phd, et al. Mol. Med. (2010). In press: Le Clerc, S., et al. J. Infect. Dis. 200(8):1194-1201(2009). Hwang, Y., et al. Pharmacogenomics 7(5):697-709(2006). Wurthner, J.U., et al. J. Biol. Chem. 276(22):19495-19502(2001). Provost, P., et al. Proc. Natl. Acad. Sci. U.S.A. 96(5):1881-1885(1999).

Other Notes

Small volumes of anti-TGFBRAP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TGFBRAP1 purchase

MBS6355226 is an antibody targeting TGFBRAP1. Also known as TGFBRAP1, CT (TGFBRAP1, Transforming growth factor-beta receptor-associated protein 1) (MaxLight 750). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TGFBRAP1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
transforming growth factor-beta receptor-associated protein 1 isoform 1
NCBI Official Synonym Full Names
transforming growth factor beta receptor associated protein 1
NCBI Official Symbol
TGFBRAP1
NCBI Official Synonym Symbols
VPS3; TRAP1; TRAP-1
UniProt Protein Name
Transforming growth factor-beta receptor-associated protein 1
UniProt Gene Name
TGFBRAP1
UniProt Synonym Gene Names
TGF-beta receptor-associated protein 1; TRAP-1; TRAP1
UniProt Entry Name
TGFA1_HUMAN
NCBI Protein Information
transforming growth factor-beta receptor-associated protein 1

NCBI Summary for TGFBRAP1

This gene encodes a protein that binds to transforming growth factor-beta (TGF-beta) receptors and plays a role in TGF-beta signaling. The encoded protein acts as a chaprone in signaling downstream of TGF-beta. It is involved in signal-dependent association with SMAD4. The protein is also a component of mammalian CORVET, a multisubunit tethering protein complex that is involved in fusion of early endosomes. [provided by RefSeq, Jun 2016]
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UniProt Comments for TGFBRAP1

TGFBRAP1: Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2. Belongs to the TRAP1 family.

Chromosomal Location of Human Ortholog: 2q12.1

Cellular Component: membrane; cytoplasm

Molecular Function: protein binding; SMAD binding; transforming growth factor beta receptor binding

Biological Process: vesicle-mediated transport; intracellular protein transport; regulation of transcription, DNA-dependent; regulation of catalytic activity; transforming growth factor beta receptor signaling pathway; signal transduction
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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