TGM3 Antibody – Rabbit Polyclonal

Function: Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold. In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath

By similarity.

Catalytic activity: Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.

Cofactor: Binds 1 calcium ion per subunit

By similarity.

Subunit structure: Consists of two polypeptide chains, which are synthesized as a precursor form of a single polypeptide

By similarity.

Post-translational modification: Activated by proteolytic processing. In vitro activation is commonly achieved by cleavage with dispase, a neutral bacterial protease. Physiological activation may be catalyzed by CTSL and, to a lesser extent, by CTSS

By similarity.

Sequence similarities: Belongs to the transglutaminase superfamily. Transglutaminase family.