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TLK2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9146256

This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4… More details

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Product Overview

Online Datasheet in PDF
Product Name
TLK2, Polyclonal Antibody
Full Product Name
TLK2 Rabbit pAb
Product Gene Name
anti-TLK2 antibody
Product Synonym Names
HsHPK; MRD57; PKU-ALPHA
Immunogen Sequence
MMEELHSLDP RRQELLEARF TGVGVSKGPL NSESSNQSLC SVGSLSDKEV ETPEKKQNDQ RNRKRKAEPY ETSQGKGTPR GHKISDYFEF AGGSAPGTSP GRSVPPVARS SPQHSLSNPL PRRVEQPLYG LDGSAAKEAT EEQSALPTLM SVMLAKPRLD TEQLAQRGAG LCFTFVSAQQ NSPSSTGSGN TEHSCSSQKQ ISIQHRQTQS DLTIEKISAL
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purity/Purification
Affinity purification
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Ship: Ice Pack
Molecular Weight
87,661 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (60556386..60692842). Location: 17q23
OMIM
608439
3D Structure
ModBase 3D Structure for Q86UE8
Cellular Location
Cytoplasm, Nucleus, cytoskeleton, perinuclear region
Research Area
Epigenetics Nuclear Signaling, Signal Transduction, Kinase, Cell Biology Developmental Biology, Apoptosis, Cell Cycle
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human TLK2 (NP_006843.2).

Product Categories/Family for anti-TLK2 antibody

Polyclonal Antibodies
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-TLK2 antibody
Western Blot (WB)
Application Notes for anti-TLK2 antibody
WB: 1:500-1:2000

Other Notes

Small volumes of anti-TLK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TLK2 purchase

MBS9146256 is an antibody targeting TLK2. Also known as TLK2 Rabbit pAb. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TLK2. It may not necessarily be applicable to this product.

NCBI GI #
162951881
NCBI GeneID
11011
NCBI Accession #
NP_001106178.1
UniProt Primary Accession #
Q86UE8
UniProt Secondary Accession #
Q9UKI7; Q9Y4F7; D3DU07
UniProt Related Accession #
Q86UE8
GenBank Nucleotide #
NM_001112707.1
NCBI Official Full Name
serine/threonine-protein kinase tousled-like 2 isoform B
NCBI Official Synonym Full Names
tousled-like kinase 2
NCBI Official Symbol
TLK2
NCBI Official Synonym Symbols
HsHPK; PKU-ALPHA
UniProt Protein Name
Serine/threonine-protein kinase tousled-like 2
UniProt Synonym Protein Names
HsHPK; PKU-alpha; Tousled-like kinase 2
Protein Family
Serine/threonine-protein kinase tousled
UniProt Gene Name
TLK2
UniProt Entry Name
TLK2_HUMAN
NCBI Protein Information
serine/threonine-protein kinase tousled-like 2; serine/threonine kinase

NCBI Summary for TLK2

The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM, Apr 2004]

UniProt Comments for TLK2

TLK2: Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, Other; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Other group; TLK family

Chromosomal Location of Human Ortholog: 17q23

Cellular Component: perinuclear region of cytoplasm; intermediate filament; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding

Biological Process: negative regulation of autophagy; peptidyl-serine phosphorylation; regulation of chromatin assembly or disassembly; chromatin modification; cell cycle; protein amino acid phosphorylation; response to DNA damage stimulus; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; chromosome segregation
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Research Articles on TLK2

1. TLKs appear to be intimately linked to the pattern of resistance to DNA damage, and specifically double-strand breaks.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TLK2 antibody

 Reference Product  PubMed Publications
 TLK1 antibody  >4 publications with TLK2 and TLK1

Pathways associated with anti-TLK2 antibody

 Products by Pathway  Pathway Diagram
 DNA Damage Response Pathway antibodies  DNA Damage Response Pathway Diagram

Diseases associated with anti-TLK2 antibody

 Disease Name  Pubmed Publications
 Infertility, Male Antibodies  >1 publications with TLK2 and Infertility, Male
 Prostatic Diseases Antibodies  >1 publications with TLK2 and Prostatic Diseases
 Abnormalities, Multiple Antibodies  >1 publications with TLK2 and Abnormalities, Multiple

Organs/Tissues associated with anti-TLK2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with TLK2 and Brain
 Blood Antibodies  >1 publications with TLK2 and Blood
 Prostate Antibodies  >1 publications with TLK2 and Prostate
 Connective Tissue Antibodies  >1 publications with TLK2 and Connective Tissue
 Testis Antibodies  >1 publications with TLK2 and Testis
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