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TMC8 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6356167

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in… More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TMC8, Polyclonal Antibody
Full Product Name
TMC8, NT (TMC8, EVER2, EVIN2, Transmembrane channel-like protein 8, Epidermodysplasia verruciformis protein 2) (Azide free) (HRP)
Product Gene Name
anti-TMC8 antibody
Product Synonym Names
TMC8; EVER2; EVIN2; Transmembrane channel-like protein 8; Epidermodysplasia verruciformis protein 2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
81,641 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (76126859..76139049). Location: 17q25.3
OMIM
226400
3D Structure
ModBase 3D Structure for Q8IU68
Immunogen
TMC8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 49-79 amino acids from the N-terminal region of human TMC8.
Conjugate
HRP
Note
Preservative Free

Product Categories/Family for anti-TMC8 antibody

Antibodies; Transmembrane Proteins
Applications Tested/Suitable for anti-TMC8 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-TMC8 antibody
WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-TMC8 antibody

TMC8 Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the TMC8 antibody detected the TMC8 protein (arrow).
Rabbit Anti-TMC8 Polyclonal Antibody – Cat# MBS6356167

Product References and Citations for anti-TMC8 antibody

McDermott, D.F., et al. Pediatr Dermatol 26(3):306-310(2009). Patel, A.S., et al. Int. J. Cancer 122(10):2377-2379(2008). Zavattaro, E., et al. J. Invest. Dermatol. 128(3):732-735(2008). Lazarczyk, M., et al. J. Exp. Med. 205(1):35-42(2008). Rady, P.L., et al. Br. J. Dermatol. 157(4):831-833(2007).

Other Notes

Small volumes of anti-TMC8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TMC8 purchase

MBS6356167 is an antibody targeting TMC8. Also known as TMC8, NT (TMC8, EVER2, EVIN2, Transmembrane channel-like protein 8, Epidermodysplasia verruciformis protein 2) (Azide free) (HRP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TMC8. It may not necessarily be applicable to this product.

NCBI GI #
23943900
NCBI GeneID
147138
NCBI Accession #
NP_689681.2
UniProt Primary Accession #
Q8IU68
UniProt Secondary Accession #
Q2YDC0; Q8IWU7; Q8N358; Q8NF04
UniProt Related Accession #
Q8IU68
GenBank Nucleotide #
NM_152468.4
NCBI Official Full Name
transmembrane channel-like protein 8
NCBI Official Synonym Full Names
transmembrane channel-like 8
NCBI Official Symbol
TMC8
NCBI Official Synonym Symbols
EV2; EVER2; EVIN2
UniProt Protein Name
Transmembrane channel-like protein 8
UniProt Synonym Protein Names
Epidermodysplasia verruciformis protein 2
Protein Family
Transmembrane channel-like protein
UniProt Gene Name
TMC8
UniProt Synonym Gene Names
EVER2; EVIN2
UniProt Entry Name
TMC8_HUMAN
NCBI Protein Information
transmembrane channel-like protein 8; epidermodysplasia verruciformis 2; epidermodysplasia verruciformis protein 2

UniProt Comments for TMC8

TMC8: an endoplasmic reticulum multipass membrane protein. Defects in TMC8 cause Lutz-Lewandowsky epidermodysplasia verruciformis [MIM:226400], a rare skin disease characterized by increased susceptibility to infection by papillomaviruses with an accompanying high risk of skin carcinoma. Three splice-variant isoforms of the human protein have been described.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: Golgi apparatus; extracellular space; endoplasmic reticulum membrane; nuclear membrane; endoplasmic reticulum; cytoplasm; integral to membrane

Molecular Function: protein binding; receptor binding

Biological Process: negative regulation of protein oligomerization; zinc ion homeostasis; ion transport; regulation of cell growth; negative regulation of protein binding

Disease: Epidermodysplasia Verruciformis
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Research Articles on TMC8

1. EVER2-deficient patients display mild T-cell abnormalities: a significant increase of memory CD4+ and effector memory CD8+ T cells, a bias of the T cell receptor Valphabeta and Vgammadelta repertoires and an increase of skin-homing CD4+ T-cell subsets.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-TMC8 antibody

 Disease Name  Pubmed Publications
 Epidermodysplasia Verruciformis Antibodies  >26 publications with TMC8 and Epidermodysplasia Verruciformis
 Neoplasms Antibodies  >24 publications with TMC8 and Neoplasms
 Carcinoma Antibodies  >11 publications with TMC8 and Carcinoma
 Skin Neoplasms Antibodies  >7 publications with TMC8 and Skin Neoplasms
 Immune System Diseases Antibodies  >3 publications with TMC8 and Immune System Diseases
 Bowen's Disease Antibodies  >1 publications with TMC8 and Bowen's Disease
 Chronic Disease Antibodies  >1 publications with TMC8 and Chronic Disease
 Necrosis Antibodies  >1 publications with TMC8 and Necrosis
 Carcinoma in Situ Antibodies  >1 publications with TMC8 and Carcinoma in Situ
 Nervous System Diseases Antibodies  >1 publications with TMC8 and Nervous System Diseases

Organs/Tissues associated with anti-TMC8 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >20 publications with TMC8 and Skin
 Blood Antibodies  >4 publications with TMC8 and Blood
 Eye Antibodies  >1 publications with TMC8 and Eye
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