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TMPO Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6356661

The protein encoded by this gene resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. It may function as a receptor for the attachment of lamin filaments… More details

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Product Overview

Online Datasheet in PDF
Product Name
TMPO, Polyclonal Antibody
Full Product Name
TMPO, NT (TMPO, LAP2, Lamina-associated polypeptide 2, isoform alpha, Thymopoietin isoform alpha, Thymopoietin-related peptide isoform alpha, Thymopoietin, Splenin, Thymopentin, TP5) (FITC)
Product Gene Name
anti-TMPO antibody
Product Synonym Names
TMPO; LAP2; Lamina-associated polypeptide 2; isoform alpha; Thymopoietin isoform alpha; Thymopoietin-related peptide isoform alpha; Thymopoietin; Splenin; Thymopentin; TP5
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
50,670 Da
OMIM
gene 613740
3D Structure
ModBase 3D Structure for P42166
Immunogen
TMPO antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-195 amino acids from the N-terminal region of human TMPO.
Conjugate
FITC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-TMPO antibody

Antibodies; Lamin; Laminin
Applications Tested/Suitable for anti-TMPO antibody
Immunohistochemistry (IHC), FLISA, Western Blot (WB)
Application Notes for anti-TMPO antibody
IHC: 1:10-50
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-TMPO antibody

TMPO Antibody (N-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the TMPO antibody detected the TMPO protein (arrow).
Rabbit Anti-TMPO Polyclonal Antibody – Cat# MBS6356661

Immunohistochemistry (IHC) of anti-TMPO antibody

TMPO Antibody (N-term) (AP14741a)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TMPO Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-TMPO Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6356661

Product References and Citations for anti-TMPO antibody

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Davila, S., et al. Genes Immun. 11(3):232-238(2010). Craig, D.W., et al. Diabet. Med. 26(11):1090-1098(2009). Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009). Shaklai, S., et al. Eur. J. Cell Biol. 87(5):267-278(2008).

Other Notes

Small volumes of anti-TMPO antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TMPO purchase

MBS6356661 is an antibody targeting TMPO. Also known as TMPO, NT (TMPO, LAP2, Lamina-associated polypeptide 2, isoform alpha, Thymopoietin isoform alpha, Thymopoietin-related peptide isoform alpha, Thymopoietin, Splenin, Thymopentin, TP5) (FITC). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TMPO. It may not necessarily be applicable to this product.

NCBI GI #
4507555
NCBI GeneID
7112
NCBI Accession #
NP_003267.1
UniProt Primary Accession #
P42166
UniProt Secondary Accession #
P08918; P08919; Q14860; Q16295
UniProt Related Accession #
P42166; P42167
GenBank Nucleotide #
NM_003276.2
NCBI Official Full Name
thymopoietin isoform alpha
NCBI Official Synonym Full Names
thymopoietin
NCBI Official Symbol
TMPO
NCBI Official Synonym Symbols
TP; LAP2; CMD1T; LEMD4; PRO0868
UniProt Protein Name
Lamina-associated polypeptide 2, isoform alpha
UniProt Synonym Protein Names
Thymopoietin isoform alpha; TP alpha; Thymopoietin-related peptide isoform alpha; TPRP isoform alpha
Protein Family
Lamina-associated polypeptide
UniProt Gene Name
TMPO
UniProt Synonym Gene Names
LAP2; TP alpha; TPRP isoform alpha; TP
UniProt Entry Name
LAP2A_HUMAN
NCBI Protein Information
thymopoietin; TP alpha; TP beta/gamma; LEM domain containing 4; lamina-associated polypeptide 2; thymopoietin-related peptide isoform alpha; thymopoietin-related peptide isoforms beta/gamma

UniProt Comments for TMPO

TMPO iso6: a single-pass type II membrane protein. Tightly associated with the nuclear lamina. Binds DNA and involved in DNA replication and chromatin remodeling, May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with HAP95. Associated with dilated cardiomyopathy; upregulated in medulloblastoma. Used as a pharmaceutical to treat primary and secondary immune deficiencies, autoimmunity, infections and cancer. Available under the names Timunox (Cilag), Sintomodulina (Italofarmaco) and Mepentil (Recordati). Three alternatively spliced isoforms have been described.

Protein type: DNA-binding; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q22

Cellular Component: nuclear membrane; membrane; cytoplasm; integral to membrane; nuclear inner membrane; nuclear envelope; chromatin; nucleus

Molecular Function: protein binding; DNA binding; lamin binding

Biological Process: regulation of transcription, DNA-dependent

Disease: Cardiomyopathy, Dilated, 1t
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Research Articles on TMPO

1. Data indicate that cells lacking either high mobility group protein N5 (HMGN5) and lamina-associated polypeptide 2alpha (LAP2alpha) showed that loss of either protein affects the genome-wide distribution of the remaining partner.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TMPO antibody

 Reference Product  PubMed Publications
 LMNA antibody  >2 publications with TMPO and LMNA

Pathways associated with anti-TMPO antibody

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Clearance Of Nuclear Envelope Membranes From Chromatin Pathway antibodies  Clearance Of Nuclear Envelope Membranes From Chromatin Pathway Diagram
 Depolymerisation Of The Nuclear Lamina Pathway antibodies  Depolymerisation Of The Nuclear Lamina Pathway Diagram
 Initiation Of Nuclear Envelope Reformation Pathway antibodies  Initiation Of Nuclear Envelope Reformation Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic Anaphase Pathway antibodies  Mitotic Anaphase Pathway Diagram
 Mitotic Metaphase And Anaphase Pathway antibodies  Mitotic Metaphase And Anaphase Pathway Diagram
 Mitotic Prophase Pathway antibodies  Mitotic Prophase Pathway Diagram
 Nuclear Envelope Breakdown Pathway antibodies  Nuclear Envelope Breakdown Pathway Diagram

Diseases associated with anti-TMPO antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >6 publications with TMPO and Cardiovascular Diseases
 Kidney Diseases Antibodies  >5 publications with TMPO and Kidney Diseases
 Heart Diseases Antibodies  >5 publications with TMPO and Heart Diseases
 Inflammation Antibodies  >4 publications with TMPO and Inflammation
 Disease Models, Animal Antibodies  >3 publications with TMPO and Disease Models, Animal
 Necrosis Antibodies  >2 publications with TMPO and Necrosis
 Lung Neoplasms Antibodies  >2 publications with TMPO and Lung Neoplasms
 Weight Gain Antibodies  >2 publications with TMPO and Weight Gain
 Cardiomyopathy, Dilated Antibodies  >2 publications with TMPO and Cardiomyopathy, Dilated
 Renal Insufficiency Antibodies  >2 publications with TMPO and Renal Insufficiency

Organs/Tissues associated with anti-TMPO antibody

 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >9 publications with TMPO and Pancreas
 Blood Antibodies  >9 publications with TMPO and Blood
 Kidney Antibodies  >8 publications with TMPO and Kidney
 Bone Antibodies  >5 publications with TMPO and Bone
 Heart Antibodies  >5 publications with TMPO and Heart
 Muscle Antibodies  >4 publications with TMPO and Muscle
 Thymus Antibodies  >4 publications with TMPO and Thymus
 Brain Antibodies  >4 publications with TMPO and Brain
 Liver Antibodies  >3 publications with TMPO and Liver
 Lung Antibodies  >2 publications with TMPO and Lung
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