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TNFAIP8 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6356849

Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and… More details

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Product Overview

Online Datasheet in PDF
Product Name
TNFAIP8, Polyclonal Antibody
Full Product Name
TNFAIP8, NT (TNFAIP8, Tumor necrosis factor alpha-induced protein 8, Head and neck tumor and metastasis-related protein, MDC-3.13, NF-kappa-B-inducible DED-containing protein, SCC-S2, TNF-induced protein GG2-1) (Azide free) (HRP)
Product Gene Name
anti-TNFAIP8 antibody
Product Synonym Names
TNFAIP8; Tumor necrosis factor alpha-induced protein 8; Head and neck tumor and metastasis-related protein; MDC-3.13; NF-kappa-B-inducible DED-containing protein; SCC-S2; TNF-induced protein GG2-1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
24,385 Da
OMIM
612111
3D Structure
ModBase 3D Structure for O95379
Immunogen
TNFAIP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-78 amino acids from the N-terminal region of human TNFAIP8.
Conjugate
HRP
Note
Preservative Free

Product Categories/Family for anti-TNFAIP8 antibody

Antibodies; Growth Factors; Cytokines
Applications Tested/Suitable for anti-TNFAIP8 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-TNFAIP8 antibody
WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-TNFAIP8 antibody

TNFAIP8 Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the TNFAIP8 antibody detected the TNFAIP8 protein (arrow).
Rabbit Anti-TNFAIP8 Polyclonal Antibody – Cat# MBS6356849

Flow Cytometry (FC/FACS) of anti-TNFAIP8 antibody

TNFAIP8 Antibody (N-term) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-TNFAIP8 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6356849

Product References and Citations for anti-TNFAIP8 antibody

Dong, Q.Z., et al. Cancer Sci. 101(6):1562-1569(2010). Zhang, L.J., et al. J. Biol. Chem. 284(10):6156-6168(2009). Lamesch, P., et al. Genomics 89(3):307-315(2007). Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007): Kumar, D., et al. Oncogene 23(2):612-616(2004).

Other Notes

Small volumes of anti-TNFAIP8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNFAIP8 purchase

MBS6356849 is an antibody targeting TNFAIP8. Also known as TNFAIP8, NT (TNFAIP8, Tumor necrosis factor alpha-induced protein 8, Head and neck tumor and metastasis-related protein, MDC-3.13, NF-kappa-B-inducible DED-containing protein, SCC-S2, TNF-induced protein GG2-1) (Azide free) (HRP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFAIP8. It may not necessarily be applicable to this product.

NCBI GI #
117676365
NCBI GeneID
25816
NCBI Accession #
NP_055165.2
NCBI Related Accession #
NP_001071122.1
UniProt Primary Accession #
O95379
UniProt Secondary Accession #
Q9P1Q1; Q9UER5; Q9UP47; B3KMH1; B3KMI2; B7Z713
UniProt Related Accession #
O95379
GenBank Nucleotide #
NM_014350.3
NCBI Official Full Name
tumor necrosis factor alpha-induced protein 8 isoform a
NCBI Official Synonym Full Names
tumor necrosis factor, alpha-induced protein 8
NCBI Official Symbol
TNFAIP8
NCBI Official Synonym Symbols
NDED; GG2-1; SCCS2; SCC-S2; MDC-3.13
UniProt Protein Name
Tumor necrosis factor alpha-induced protein 8
UniProt Synonym Protein Names
Head and neck tumor and metastasis-related protein; MDC-3.13; NF-kappa-B-inducible DED-containing protein; NDED; SCC-S2; TNF-induced protein GG2-1
Protein Family
Tumor necrosis factor alpha-induced protein
UniProt Gene Name
TNFAIP8
UniProt Synonym Gene Names
TNF alpha-induced protein 8; NDED
UniProt Entry Name
TFIP8_HUMAN
NCBI Protein Information
tumor necrosis factor alpha-induced protein 8; TNF-induced protein GG2-1; TNF alpha-induced protein 8; NF-kappa-B-inducible DED-containing protein; head and neck tumor and metastasis-related protein

UniProt Comments for TNFAIP8

TNFAIP8: Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation. Belongs to the TNFAIP8 family. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 5q23.1

Cellular Component: cytoplasm

Molecular Function: caspase inhibitor activity

Biological Process: defense response to Gram-positive bacterium; interleukin-1 beta production; negative regulation of caspase activity; negative regulation of apoptosis
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Research Articles on TNFAIP8

1. TNFAIP8 may be used as a prognostic marker for the recurrence of endometrial cancer (EC), and its promotion of the proliferation and metastasis in EC may be due to its mediation of Ki-67 and MMP9.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TNFAIP8 antibody

 Reference Product  PubMed Publications
 TNF antibody  >8 publications with TNFAIP8 and TNF

Diseases associated with anti-TNFAIP8 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >25 publications with TNFAIP8 and Necrosis
 Inflammation Antibodies  >7 publications with TNFAIP8 and Inflammation
 Neoplasm Metastasis Antibodies  >5 publications with TNFAIP8 and Neoplasm Metastasis
 Disease Models, Animal Antibodies  >3 publications with TNFAIP8 and Disease Models, Animal
 Prostatic Diseases Antibodies  >2 publications with TNFAIP8 and Prostatic Diseases
 Ovarian Neoplasms Antibodies  >2 publications with TNFAIP8 and Ovarian Neoplasms
 Adenocarcinoma Antibodies  >2 publications with TNFAIP8 and Adenocarcinoma
 Lung Neoplasms Antibodies  >2 publications with TNFAIP8 and Lung Neoplasms
 Nervous System Diseases Antibodies  >2 publications with TNFAIP8 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >1 publications with TNFAIP8 and Cardiovascular Diseases

Organs/Tissues associated with anti-TNFAIP8 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >2 publications with TNFAIP8 and Lung
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