TP53INP1 Antibody – Rabbit Polyclonal

TP53INP1: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Cell cycle regulation; Tumor suppressor

Chromosomal Location of Human Ortholog: 8q22

Cellular Component: autophagic vacuole; cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function: antioxidant activity; protein binding

Biological Process: autophagic cell death; autophagic vacuole formation; cell cycle arrest; negative regulation of cell migration; negative regulation of cell proliferation; positive regulation of autophagy; positive regulation of transcription, DNA-dependent; regulation of apoptosis; response to stress