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TRA2B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS647917

TRA2B is a sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
TRA2B, Polyclonal Antibody
Full Product Name
TRA2B, ID (TRA2B, SFRS10, Transformer-2 protein homolog beta, Splicing factor, arginine/serine-rich 10, Transformer-2 protein homolog B)
Product Gene Name
anti-Tra2b antibody
Product Synonym Names
Anti -TRA2B, ID (TRA2B, SFRS10, Transformer-2 protein homolog beta, Splicing factor, arginine/serine-rich 10, Transformer-2 protein homolog B)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
33,666 Da
Chromosome Location
Chromosome: 16; NC_000082.6 (22245741..22265929, complement). Location: 16 B1; 16 13.18 cM
3D Structure
ModBase 3D Structure for P62996
Immunogen
TRA2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 207-237 amino acids from the Central region of human TRA2B.

Product Categories/Family for anti-Tra2b antibody

Antibodies; Abs to Splicing Factors
Applications Tested/Suitable for anti-Tra2b antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-Tra2b antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Western Blot (WB) of anti-Tra2b antibody

TRA2B Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the TRA2B antibody detected the TRA2B protein (arrow).
Rabbit Anti-TRA2B Polyclonal Antibody – Cat# MBS647917

Immunohistochemistry (IHC) of anti-Tra2b antibody

TRA2B Antibody (Center) (AP14688c)immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TRA2B Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-TRA2B Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS647917

Other Notes

Small volumes of anti-Tra2b antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Tra2b purchase

MBS647917 is an antibody targeting Tra2b. Also known as TRA2B, ID (TRA2B, SFRS10, Transformer-2 protein homolog beta, Splicing factor, arginine/serine-rich 10, Transformer-2 protein homolog B). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Tra2b. It may not necessarily be applicable to this product.

NCBI GI #
6677975
NCBI GeneID
20462
NCBI Accession #
NP_033212.1
UniProt Primary Accession #
P62996
UniProt Secondary Accession #
O15449; Q15815; Q64283
UniProt Related Accession #
P62996
GenBank Nucleotide #
NM_009186.4
NCBI Official Full Name
transformer-2 protein homolog beta
NCBI Official Synonym Full Names
transformer 2 beta homolog (Drosophila)
NCBI Official Symbol
Tra2b
NCBI Official Synonym Symbols
SIG-41; Sfrs10; Silg41; TRA2beta; D16Ertd266e; 5730405G21Rik
UniProt Protein Name
Transformer-2 protein homolog beta
UniProt Synonym Protein Names
Silica-induced gene 41 protein; SIG-41; Splicing factor, arginine/serine-rich 10; Transformer-2 protein homolog B
Protein Family
Transformer-2 protein
UniProt Gene Name
Tra2b
UniProt Synonym Gene Names
Sfrs10; Silg41; TRA-2 beta; TRA2-beta; SIG-41
UniProt Entry Name
TRA2B_MOUSE
NCBI Protein Information
transformer-2 protein homolog beta; TRA2-beta; TRA-2 beta; silica-induced gene 41 protein; transformer-2 protein homolog B; splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)

UniProt Comments for Tra2b

Function: Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA

By similarity.

Subunit structure: Found in a pre-mRNA exonic splicing enhancer (ESE) complex with TRA2B/SFRS10, SNRNP70, SNRPA1 and SRRM1. Binds to A3 enhancer proteins SFRS4, SFRS5, SFRS6 and SFRS9. Interacts with CPSF6, RBMY1A1, RNPS1, SAFB/SAFB1, RBMX and phosphorylated SFRS13A

By similarity.

Subcellular location: Nucleus

By similarity.

Tissue specificity: Widely expressed. Highly expressed in uterus and brain. Ref.2

Induction: Induced by reoxygenation following hypoxia and by exposure to silica. Repressed by interferon gamma, LPS and TPA. Ref.1

Sequence similarities: Belongs to the splicing factor SR family.Contains 1 RRM (RNA recognition motif) domain.
Show more

Research Articles on Tra2b

1. Tra2beta, by regulating the splicing of Mypt1 E23, sets the sensitivity of smooth muscle to cGMP-mediated relaxation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Tra2b antibody

 Products by Pathway  Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 MRNA Processing Pathway antibodies  MRNA Processing Pathway Diagram

Diseases associated with anti-Tra2b antibody

 Disease Name  Pubmed Publications
 Atrophy Antibodies  >6 publications with Tra2b and Atrophy
 Brain Diseases Antibodies  >6 publications with Tra2b and Brain Diseases
 Cardiovascular Diseases Antibodies  >5 publications with Tra2b and Cardiovascular Diseases
 Neoplasms Antibodies  >4 publications with Tra2b and Neoplasms
 Heart Diseases Antibodies  >3 publications with Tra2b and Heart Diseases
 Breast Neoplasms Antibodies  >1 publications with Tra2b and Breast Neoplasms
 Uterine Cervical Neoplasms Antibodies  >1 publications with Tra2b and Uterine Cervical Neoplasms
 Disease Models, Animal Antibodies  >1 publications with Tra2b and Disease Models, Animal
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