Rabbit Anti-TRF Polyclonal Antibody – Cat# MBS6502292

Western blot analysis of anti-TERF1(C-term) Pab in Jurkat cell line lysates (35ug/lane). TERF1(C-term)(arrow) was detected using the purified Pab.

TRF Antibody – Rabbit Polyclonal

Name: TRF Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6502292
Price: 1025 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6502292

MBS6502292 is an antibody targeting TRF. Also known as TRF, CT (Telomeric Repeat Binding Factor 1, TTAGGG Repeat-binding Factor 1, NIMA-interacting Protein 2, Telomeric Protein Pin2/TRF1, TERF1, PIN2, TRBF1, TRF, TRF1) (MaxLight 750). Reactive in Human. Host:… More details

$1025 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TRF, Polyclonal Antibody

Full Product Name

TRF, CT (Telomeric Repeat Binding Factor 1, TTAGGG Repeat-binding Factor 1, NIMA-interacting Protein 2, Telomeric Protein Pin2/TRF1, TERF1, PIN2, TRBF1, TRF, TRF1) (MaxLight 750)

Product Gene Name

anti-TRF antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.

Purity/Purification

Purified by Ammonium Sulfate Precipitation.

Specificity

Recognizes human TERF1.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

48kDa

OMIM

600951

3D Structure

ModBase 3D Structure for P54274

Immunogen

Synthetic peptide selected from the C-terminal region of human TERF1 (KLH).

Conjugate

MaxLight750

Note

Preservative Free

Product Categories/Family for anti-TRF antibody

Antibodies; Binding Proteins

Applications Tested/Suitable for anti-TRF antibody

Western Blot (WB), FLISA

Application Notes for anti-TRF antibody

WB: 1:50-1:100
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-TRF antibody

1. Kim, M.K., J. Biol. Chem. 283(20), 14144-14152 (2008). 2. Etheridge, K.T., J. Biol. Chem. 283(11), 6935-6941 (2008). 3. Muramatsu, Y., Exp. Cell Res. 314(5), 1115-1124 (2008).

Other Notes

Small volumes of anti-TRF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TRF. It may not necessarily be applicable to this product.

NCBI GI #

189409142

NCBI GeneID

7013

NCBI Accession #

NP_059523

UniProt Primary Accession #

P54274

UniProt Related Accession #

P54274

GenBank Nucleotide #

NM_017489.3

NCBI Official Full Name

telomeric repeat-binding factor 1 isoform 1

NCBI Official Synonym Full Names

telomeric repeat binding factor 1

NCBI Official Symbol

TERF1

NCBI Official Synonym Symbols

TRF; PIN2; TRF1; TRBF1; t-TRF1; hTRF1-AS

UniProt Protein Name

Telomeric repeat-binding factor 1

UniProt Synonym Protein Names

NIMA-interacting protein 2; TTAGGG repeat-binding factor 1; Telomeric protein Pin2/TRF1

Protein Family

TBP-related factor

UniProt Gene Name

TERF1

UniProt Synonym Gene Names

PIN2; TRBF1; TRF; TRF1

UniProt Entry Name

TERF1_HUMAN

NCBI Protein Information

telomeric repeat-binding factor 1

NCBI Summary for TRF

This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. [provided by RefSeq, Jul 2008]

UniProt Comments for TRF

TRF1: a telomeric repeat binding factor. Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Colocalizes with telomeric DNA in interphase and metaphase cells and is located at chromosome ends during metaphase. Involved in the regulation of the mitotic spindle. Expression is tightly regulated during the cell cycle; levels are low in G1 and S phase and increase during G2 phase and mitosis. Two splice variant isoforms have been described.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 8q21.11

Cellular Component: nucleoplasm; chromosome, telomeric region; nuclear telomere cap complex; nuclear chromosome, telomeric region; cytoplasm; nucleolus; spindle; nucleus

Molecular Function: protein binding; protein homodimerization activity; DNA binding; protein heterodimerization activity; microtubule binding; telomeric DNA binding; double-stranded telomeric DNA binding; chromatin binding; DNA bending activity

Biological Process: response to drug; mitosis; positive regulation of mitosis; negative regulation of telomere maintenance via semi-conservative replication; positive regulation of apoptosis; positive regulation of microtubule polymerization; telomere maintenance via telomerase; positive regulation of mitotic cell cycle; negative regulation of telomerase activity; cell division; negative regulation of DNA replication; telomeric loop formation; mitotic cell cycle spindle assembly checkpoint; G2/M transition of mitotic cell cycle; age-dependent telomere shortening; telomere maintenance; negative regulation of telomere maintenance via telomerase; protein homooligomerization

Research Articles on TRF

1. Findings suggest that rescuing naturally decreased TRF1 levels during mouse aging using AAV9-TRF1 gene therapy results in an improved health span.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TRF antibody

Reference Product	PubMed Publications
POT1 antibody	>12 publications with TRF and POT1
TINF2 antibody	>6 publications with TRF and TINF2
ACD antibody	>5 publications with TRF and ACD
TNKS2 antibody	>4 publications with TRF and TNKS2
TNKS antibody	>4 publications with TRF and TNKS
ATM antibody	>3 publications with TRF and ATM

Pathways associated with anti-TRF antibody

Products by Pathway	Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cellular Senescence Pathway antibodies	Cellular Senescence Pathway Diagram
Cellular Responses To Stress Pathway antibodies	Cellular Responses To Stress Pathway Diagram
Chromosome Maintenance Pathway antibodies	Chromosome Maintenance Pathway Diagram
DNA Damage/Telomere Stress Induced Senescence Pathway antibodies	DNA Damage/Telomere Stress Induced Senescence Pathway Diagram
Meiosis Pathway antibodies	Meiosis Pathway Diagram
Meiotic Synapsis Pathway antibodies	Meiotic Synapsis Pathway Diagram
Packaging Of Telomere Ends Pathway antibodies	Packaging Of Telomere Ends Pathway Diagram
Regulation Of Telomerase Pathway antibodies	Regulation Of Telomerase Pathway Diagram
Shelterin Complex Pathway antibodies	Shelterin Complex Pathway Diagram

Diseases associated with anti-TRF antibody

Disease Name	Pubmed Publications
Lung Diseases Antibodies	>3 publications with TRF and Lung Diseases
Anemia Antibodies	>3 publications with TRF and Anemia
Death Antibodies	>2 publications with TRF and Death
Myocardial Infarction Antibodies	>1 publications with TRF and Myocardial Infarction
Nervous System Diseases Antibodies	>1 publications with TRF and Nervous System Diseases
Cardiovascular Diseases Antibodies	>1 publications with TRF and Cardiovascular Diseases
Hyperplasia Antibodies	>1 publications with TRF and Hyperplasia
Kidney Diseases Antibodies	>1 publications with TRF and Kidney Diseases
Atherosclerosis Antibodies	>1 publications with TRF and Atherosclerosis
Fibrosis Antibodies	>1 publications with TRF and Fibrosis

Organs/Tissues associated with anti-TRF antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>6 publications with TRF and Blood
Bone Antibodies	>5 publications with TRF and Bone
Lung Antibodies	>4 publications with TRF and Lung
Embryonic Tissue Antibodies	>4 publications with TRF and Embryonic Tissue
Skin Antibodies	>3 publications with TRF and Skin
Muscle Antibodies	>2 publications with TRF and Muscle
Bone Marrow Antibodies	>2 publications with TRF and Bone Marrow
Brain Antibodies	>2 publications with TRF and Brain
Nerve Antibodies	>1 publications with TRF and Nerve
Eye Antibodies	>1 publications with TRF and Eye