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TRPM8 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6358878

Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved… More details

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Product Overview

Online Datasheet in PDF
Product Name
TRPM8, Polyclonal Antibody
Full Product Name
TRPM8, ID (TRPM8, LTRPC6, TRPP8, Transient receptor potential cation channel subfamily M member 8, Long transient receptor potential channel 6, Transient receptor potential p8) (MaxLight 750)
Product Gene Name
anti-TRPM8 antibody
Product Synonym Names
TRPM8; LTRPC6; TRPP8; Transient receptor potential cation channel subfamily M member 8; Long transient receptor potential channel 6; Transient receptor potential p8
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.
Purity/Purification
Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
79,096 Da
OMIM
606678
3D Structure
ModBase 3D Structure for Q7Z2W7
Immunogen
TRPM8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 270-300 amino acids from the Central region of human TRPM8.
Conjugate
MaxLight750
Note
Preservative Free

Product Categories/Family for anti-TRPM8 antibody

Antibodies; Receptors
Applications Tested/Suitable for anti-TRPM8 antibody
Immunofluorescence (IF), FLISA, Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-TRPM8 antibody
IF: 1:10-50
FLISA: 1:1,000
IHC: 1:50-100
WB: 1:50-100
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-TRPM8 antibody

TRPM8 Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the TRPM8 antibody detected the TRPM8 protein (arrow).
Rabbit Anti-TRPM8 Polyclonal Antibody – Cat# MBS6358878

Immunohistochemistry (IHC) of anti-TRPM8 antibody

TRPM8 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TRPM8 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-TRPM8 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6358878

Immunofluorescence (IF) of anti-TRPM8 antibody

Confocal immunofluorescent analysis of TRPM8 Antibody (Center) with A375 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Rabbit Anti-TRPM8 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS6358878

Product References and Citations for anti-TRPM8 antibody

Yee, N.S., et al. Cancer Lett. 297(1):49-55(2010). Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Kuhn, F.J., et al. J. Biol. Chem. 285(35):26806-26814(2010). Gkika, D., et al. Oncogene 29(32):4611-4616(2010). Van Haute, C., et al. ScientificWorldJournal 10, 1597-1611 (2010).

Other Notes

Small volumes of anti-TRPM8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TRPM8 purchase

MBS6358878 is an antibody targeting TRPM8. Also known as TRPM8, ID (TRPM8, LTRPC6, TRPP8, Transient receptor potential cation channel subfamily M member 8, Long transient receptor potential channel 6, Transient receptor potential p8) (MaxLight 750). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TRPM8. It may not necessarily be applicable to this product.

NCBI GI #
109689695
NCBI GeneID
79054
NCBI Accession #
NP_076985.4
UniProt Primary Accession #
Q7Z2W7
UniProt Secondary Accession #
Q3YFM7; Q6QNH9; Q8TAC3; Q8TDX8; Q9BVK1; A0AVG2
UniProt Related Accession #
Q7Z2W7
GenBank Nucleotide #
NM_024080.4
NCBI Official Full Name
transient receptor potential cation channel subfamily M member 8
NCBI Official Synonym Full Names
transient receptor potential cation channel subfamily M member 8
NCBI Official Symbol
TRPM8
NCBI Official Synonym Symbols
TRPP8; LTRPC6
UniProt Protein Name
Transient receptor potential cation channel subfamily M member 8
UniProt Synonym Protein Names
Long transient receptor potential channel 6; LTrpC-6; LTrpC6; Transient receptor potential p8; Trp-p8
Protein Family
Transient receptor potential cation channel subfamily
UniProt Gene Name
TRPM8
UniProt Synonym Gene Names
LTRPC6; TRPP8; LTrpC-6; LTrpC6; Trp-p8
UniProt Entry Name
TRPM8_HUMAN
NCBI Protein Information
transient receptor potential cation channel subfamily M member 8

UniProt Comments for TRPM8

TRPM8: Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM8 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Channel, cation; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: endoplasmic reticulum membrane; external side of plasma membrane; integral to membrane; lipid raft; plasma membrane

Molecular Function: calcium channel activity; protein binding; protein homodimerization activity

Biological Process: cellular calcium ion homeostasis; detection of temperature stimulus; protein homotetramerization; response to cold; thermoception
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Research Articles on TRPM8

1. TRPM8 underlines the important physiologic role of the nose in temperature regulation, both in patients with allergy and those without allergy. Isometric contraction studies demonstrate the role of TRPM8 in regulating nasal patency and airway resistance.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-TRPM8 antibody

 Products by Pathway  Pathway Diagram
 Inflammatory Mediator Regulation Of TRP Channels Pathway antibodies  Inflammatory Mediator Regulation Of TRP Channels Pathway Diagram
 Inflammatory Mediator Regulation Of TRP Channels Pathway antibodies  Inflammatory Mediator Regulation Of TRP Channels Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Stimuli-sensing Channels Pathway antibodies  Stimuli-sensing Channels Pathway Diagram
 TRP Channels Pathway antibodies  TRP Channels Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with anti-TRPM8 antibody

 Disease Name  Pubmed Publications
 Pain Antibodies  >254 publications with TRPM8 and Pain
 Hyperalgesia Antibodies  >60 publications with TRPM8 and Hyperalgesia
 Inflammation Antibodies  >58 publications with TRPM8 and Inflammation
 Disease Models, Animal Antibodies  >36 publications with TRPM8 and Disease Models, Animal
 Migraine Disorders Antibodies  >14 publications with TRPM8 and Migraine Disorders
 Migraine without Aura Antibodies  >12 publications with TRPM8 and Migraine without Aura
 Necrosis Antibodies  >11 publications with TRPM8 and Necrosis
 Hyperplasia Antibodies  >9 publications with TRPM8 and Hyperplasia
 Neoplasms, Experimental Antibodies  >8 publications with TRPM8 and Neoplasms, Experimental
 Hypertension Antibodies  >6 publications with TRPM8 and Hypertension

Organs/Tissues associated with anti-TRPM8 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >92 publications with TRPM8 and Skin
 Prostate Antibodies  >72 publications with TRPM8 and Prostate
 Brain Antibodies  >67 publications with TRPM8 and Brain
 Vascular Antibodies  >27 publications with TRPM8 and Vascular
 Eye Antibodies  >19 publications with TRPM8 and Eye
 Lung Antibodies  >18 publications with TRPM8 and Lung
 Intestine Antibodies  >15 publications with TRPM8 and Intestine
 Liver Antibodies  >12 publications with TRPM8 and Liver
 Testis Antibodies  >6 publications with TRPM8 and Testis
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